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Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

2. In Section 3, we used some vague statements to affirm the training process of the neural network, which cannot support others to reproduce the results of the paper. In addition, this section does not show the difference between this…

Optimization and Control · Mathematics 2020-07-01 Liang Xue , Jie Liu , Guilin Wen , Hongxin Wang

Persistent homology of the Rips filtration allows to track topological features of a point cloud over scales, and is a foundational tool of topological data analysis. Unfortunately, the Rips-filtration is exponentially sized, when…

Computational Geometry · Computer Science 2018-07-27 Bernhard Brehm , Hanne Hardering

Topological data analysis (TDA) has emerged as one of the most promising techniques to reconstruct the unknown shapes of high-dimensional spaces from observed data samples. TDA, thus, yields key shape descriptors in the form of persistent…

Machine Learning · Statistics 2017-11-15 Wei Guo , Krithika Manohar , Steven L. Brunton , Ashis G. Banerjee

With the rapid adoption of machine learning techniques for large-scale applications in science and engineering comes the convergence of two grand challenges in visualization. First, the utilization of black box models (e.g., deep neural…

Developing methods to process irregularly structured data is crucial in applications like gene-regulatory, brain, power, and socioeconomic networks. Graphs have been the go-to algebraic tool for modeling the structure via nodes and edges…

Signal Processing · Electrical Eng. & Systems 2025-02-17 Elvin Isufi , Geert Leus , Baltasar Beferull-Lozano , Sergio Barbarossa , Paolo Di Lorenzo

The work explores a specific scenario for structural computational optimization based on the following elements: (a) a relaxed optimization setting considering the ersatz (bi-material) approximation, (b) a treatment based on a nonsmoothed…

Computational Engineering, Finance, and Science · Computer Science 2021-08-06 J. Oliver , D. Yago , J. Cante , O. Lloberas-Valls

Real data is often given as a point cloud, i.e. a finite set of points with pairwise distances between them. An important problem is to detect the topological shape of data --- for example, to approximate a point cloud by a low-dimensional…

Algebraic Topology · Mathematics 2018-10-09 Sara Kalisnik Verovsek , Vitaliy Kurlin , Davorin Lesnik

A wide range of data that appear in scientific experiments and simulations are multivariate or multifield in nature, consisting of multiple scalar fields. Topological feature search of such data aims to reveal important properties useful to…

Computational Geometry · Computer Science 2024-06-06 Tripti Agarwal , Amit Chattopadhyay , Vijay Natarajan

Mapper is an algorithm that summarizes the topological information contained in a dataset and provides an insightful visualization. It takes as input a point cloud which is possibly high-dimensional, a filter function on it and an open…

Algebraic Topology · Mathematics 2019-03-12 Bishal Deb , Ankita Sarkar , Nupur Kumari , Akash Rupela , Piyush Gupta , Balaji Krishnamurthy

Topological methods, including persistent homology, are powerful tools for analysis of high-dimensional data sets but these methods rely almost exclusively on thresholding techniques. In noisy data sets, thresholding does not always allow…

Computational Geometry · Computer Science 2016-09-08 Jennifer Kloke , Gunnar Carlsson

Topological Data Analysis (TDA) allows us to extract powerful topological and higher-order information on the global shape of a data set or point cloud. Tools like Persistent Homology or the Euler Transform give a single complex description…

Algebraic Topology · Mathematics 2025-11-04 Vincent P. Grande , Michael T. Schaub

In this paper, we propose a low-complexity method to approximately solve the SINR-constrained optimization problem of symbol-level precoding (SLP). First, assuming a generic modulation scheme, the precoding optimization problem is recast as…

Signal Processing · Electrical Eng. & Systems 2019-03-11 Alireza Haqiqatnejad , Farbod Kayhan , Bjorn Ottersten

Given a real-valued function $f$ defined over a manifold $M$ embedded in $\mathbb{R}^d$, we are interested in recovering structural information about $f$ from the sole information of its values on a finite sample $P$. Existing methods…

Computational Geometry · Computer Science 2015-04-08 Mickaël Buchet , Frédéric Chazal , Tamal K. Dey , Fengtao Fan , Steve Y. Oudot , Yusu Wang

Topological Data Analysis (TDA) provides a pipeline to extract quantitative topological descriptors from structured objects. This enables the definition of topological loss functions, which assert to what extent a given object exhibits some…

Artificial Intelligence · Computer Science 2024-05-30 Mathieu Carriere , Marc Theveneau , Théo Lacombe

Unsupervised representation learning methods are widely used for gaining insight into high-dimensional, unstructured, or structured data. In some cases, users may have prior topological knowledge about the data, such as a known cluster…

Machine Learning · Computer Science 2023-11-08 Edith Heiter , Robin Vandaele , Tijl De Bie , Yvan Saeys , Jefrey Lijffijt

This paper presents a novel topology-aware dimensionality reduction approach aiming at accurately visualizing the cyclic patterns present in high dimensional data. To that end, we build on the Topological Autoencoders (TopoAE) formulation.…

Computational Geometry · Computer Science 2025-10-06 Mattéo Clémot , Julie Digne , Julien Tierny

In this research, we propose a deep learning based approach for speeding up the topology optimization methods. The problem we seek to solve is the layout problem. The main novelty of this work is to state the problem as an image…

Machine Learning · Computer Science 2017-09-28 Ivan Sosnovik , Ivan Oseledets

Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides…

Quantitative Methods · Quantitative Biology 2025-05-06 Maria Torras-Pérez , Iris H. R. Yoon , Praveen Weeratunga , Ling-Pei Ho , Helen M. Byrne , Ulrike Tillmann , Heather A. Harrington

In many real-world problems, we are dealing with collections of high-dimensional data, such as images, videos, text and web documents, DNA microarray data, and more. Often, high-dimensional data lie close to low-dimensional structures…

Computer Vision and Pattern Recognition · Computer Science 2013-02-06 Ehsan Elhamifar , Rene Vidal
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