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The motion of particles in random potentials occurs in several natural phenomena ranging from the mobility of organelles within a biological cell to the diffusion of stars within a galaxy. A Brownian particle moving in the random optical…

Optics · Physics 2014-02-06 Giorgio Volpe , Giovanni Volpe , Sylvain Gigan

Heterogeneous diffusion processes are prevalent in various fields, including the motion of proteins in living cells, the migratory movement of birds and mammals, and finance. These processes are often characterized by time-varying dynamics,…

Statistical Mechanics · Physics 2025-03-11 Michał Balcerek , Adrian Pacheco-Pozo , Agnieszka Wyłomańska , Diego Krapf

Diffusion is a fundamental physical phenomenon with critical applications in fields such as metallurgy, cell biology, and population dynamics. While standard diffusion is well-understood, anomalous diffusion often requires complex non-local…

Statistical Mechanics · Physics 2026-01-16 Gabriel Barreiro , Vladimir Pérez-Veloz

Biophysical processes within living systems rely on encounters and interactions between molecules in complex environments such as cells. They are often described by anomalous diffusion transport. Recent advances in single-molecule…

Data Analysis, Statistics and Probability · Physics 2025-02-27 Solomon Asghar , Ran Ni , Giorgio Volpe

The transport equation of active motion is generalised to consider time-fractional dynamics for describing the anomalous diffusion of self-propelled particles observed in many different systems. In the present study, we consider an…

Statistical Mechanics · Physics 2023-10-27 Francisco J. Sevilla , Guillermo Chacón-Acosta , Trifce Sandev

Anomalous diffusion, in particular subdiffusion, is frequently invoked as a mechanism of motion in dense biological media, and may have a significant impact on the kinetics of binding/unbinding events at the cellular level. In this work we…

Statistical Mechanics · Physics 2015-06-10 S. B. Yuste , E. Abad , K. Lindenberg

This review article aims to stress and reunite some of the analytic formalism of the anomalous diffusive processes that have succeeded in their description. Also, it has the objective to discuss which of the new directions they have taken…

Statistical Mechanics · Physics 2019-05-28 Maike A. F. dos Santos

We derive the statistics of the signals generated by shape fluctuations of large molecules studied by feedback tracking microscopy. We account for the influence of intramolecular dynamics on the response of the tracking system, and derive a…

Optics · Physics 2015-05-13 Kevin McHale , Hideo Mabuchi

In recent years, fluorescence correlation spectroscopy has been increasingly applied for the study of polymer dynamics on the nanometer scale. The core idea is to extract, from a measured autocorrelation curve, an effective mean-square…

Chemical Physics · Physics 2015-06-04 Joerg Enderlein

In this article we review classical and recent results in anomalous diffusion and provide mechanisms useful for the study of the fundamentals of certain processes, mainly in condensed matter physics, chemistry and biology. Emphasis will be…

Statistical Mechanics · Physics 2019-02-25 Fernando A. Oliveira , Rogelma M. S. Ferreira , Luciano C. Lapas , Mendeli H. Vainstein

Extracting and detecting spike activities from the fluorescence observations is an important step in understanding how neuron systems work. The main challenge lies in that the combination of the ambient noise with dynamic baseline…

Neurons and Cognition · Quantitative Biology 2019-02-01 Zhuangkun Wei , Bin Li , Weisi Guo , Wenxiu Hu , Chenglin Zhao

We describe the effect of optical aberrations on fluorescence fluctuations microscopy (FFM), when focusing through a single living cell. FFM measurements are performed in an aqueous fluorescent solution and prove to be a highly sensitive…

Biological Physics · Physics 2014-03-13 Charles-Edouard Leroux , Alexei Grichine , Irène Wang , Antoine Delon

The study of the dynamics of natural and artificial systems has provided several examples of deviations from Brownian behavior, generally defined as anomalous diffusion. The investigation of these dynamics can provide a better understanding…

Data Analysis, Statistics and Probability · Physics 2025-08-29 Carlo Manzo

Motivated by the numerous healthcare applications of molecular communication within Internet of Bio-Nano Things (IoBNT), this work addresses the problem of abnormality detection in a blood vessel using multiple biological embedded computing…

Information Theory · Computer Science 2018-07-10 Neeraj Varshney , Adarsh Patel , Yansha Deng , Werner Haselmayr , Pramod K. Varshney , Arumugam Nallanathan

A ubiquitous observation in cell biology is that diffusion of macromolecules and organelles is anomalous, and a description simply based on the conventional diffusion equation with diffusion constants measured in dilute solution fails. This…

Soft Condensed Matter · Physics 2013-03-14 Felix Höfling , Thomas Franosch

Diffusion models have emerged as powerful tools for generative tasks, producing high-quality outputs across diverse domains. However, how the generated data responds to the initial noise perturbation in diffusion models remains…

Machine Learning · Computer Science 2025-02-10 Bowen Song , Zecheng Zhang , Zhaoxu Luo , Jason Hu , Wei Yuan , Jing Jia , Zhengxu Tang , Guanyang Wang , Liyue Shen

Machine learning (ML) has become a versatile tool for analyzing anomalous diffusion trajectories, yet most existing pipelines are trained on large collections of simulated data. In contrast, experimental trajectories, such as those from…

Biological Physics · Physics 2025-12-10 Gongyi Wang , Yu Zhang , Zihan Huang

The molecular motion in heterogeneous media displays anomalous diffusion by the mean-squared displacement $\langle X^2(t) \rangle = 2 D t^\alpha$. Motivated by experiments reporting populations of the anomalous diffusion parameters $\alpha$…

Biological Physics · Physics 2025-10-09 Yann Lanoiselée , Gianni Pagnini , Agnieszka Wyłomańska

Recent technological advances in cutting-edge ultrasensitive fluorescence microscopy have allowed single-molecule imaging experiments in living cells across all three domains of life to become commonplace. Single-molecule live-cell data is…

Biomolecules · Quantitative Biology 2015-04-15 Mark Leake

Flow cytometry is a widespread and powerful technique, whose resolution is determined by its capacity to accurately distinguish fluorescently positive populations from negative ones. However, most informative results are discarded while…