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The interpretation of reasoning by Deep Neural Networks (DNN) is still challenging due to their perceived black-box nature. Therefore, deploying DNNs in several real-world tasks is restricted by the lack of transparency of these models. We…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Maddimsetti Srinivas , Debdoot Sheet

Identification of causal genes and pathways is a critical step for understanding the genetic underpinnings of rare diseases. We propose novel approaches to gene prioritization and pathway identification using DNA language model, graph…

Quantitative Methods · Quantitative Biology 2024-11-12 Ali Saadat , Jacques Fellay

We present a new Deep Dictionary Learning and Coding Network (DDLCN) for image recognition tasks with limited data. The proposed DDLCN has most of the standard deep learning layers (e.g., input/output, pooling, fully connected, etc.), but…

Computer Vision and Pattern Recognition · Computer Science 2020-05-25 Hao Tang , Hong Liu , Wei Xiao , Nicu Sebe

Despite the success of deep neural networks, there are still many challenges in deep representation learning due to the data scarcity issues such as data imbalance, unseen distribution, and domain shift. To address the above-mentioned…

Computer Vision and Pattern Recognition · Computer Science 2022-04-01 Zhi Hou , Baosheng Yu , Dacheng Tao

Deep Neural Networks (DNNs) are powerful models that have achieved excellent performance on difficult learning tasks. Although DNNs work well whenever large labeled training sets are available, they cannot be used to map sequences to…

Computation and Language · Computer Science 2014-12-16 Ilya Sutskever , Oriol Vinyals , Quoc V. Le

Reading comprehension models are based on recurrent neural networks that sequentially process the document tokens. As interest turns to answering more complex questions over longer documents, sequential reading of large portions of text…

Computation and Language · Computer Science 2018-09-11 Mor Geva , Jonathan Berant

Advances in methods of biological data collection are driving the rapid growth of comprehensive datasets across clinical and research settings. These datasets provide the opportunity to monitor biological systems in greater depth and at…

Molecular Networks · Quantitative Biology 2025-01-20 Joshua Pickard , Cooper Stansbury , Amit Surana , Lindsey Muir , Anthony Bloch , Indika Rajapakse

Understanding how the brain responds to sensory inputs is challenging: brain recordings are partial, noisy, and high dimensional; they vary across sessions and subjects and they capture highly nonlinear dynamics. These challenges have led…

Neurons and Cognition · Quantitative Biology 2022-10-03 Omar Chehab , Alexandre Defossez , Jean-Christophe Loiseau , Alexandre Gramfort , Jean-Remi King

Modern sentence encoders are used to generate dense vector representations that capture the underlying linguistic characteristics for a sequence of words, including phrases, sentences, or paragraphs. These kinds of representations are ideal…

Computation and Language · Computer Science 2021-06-03 Nada Almarwani , Mona Diab

Convolutional Neural Networks (CNN) have gained great success in many artificial intelligence tasks. However, finding a good set of hyperparameters for a CNN remains a challenging task. It usually takes an expert with deep knowledge, and…

Neural and Evolutionary Computing · Computer Science 2020-06-25 Xueli Xiao , Ming Yan , Sunitha Basodi , Chunyan Ji , Yi Pan

Neural program embedding has shown potential in aiding the analysis of large-scale, complicated software. Newly proposed deep neural architectures pride themselves on learning program semantics rather than superficial syntactic features.…

Programming Languages · Computer Science 2019-05-28 Ke Wang

Machine learning in drug discovery has been focused on virtual screening of molecular libraries using discriminative models. Generative models are an entirely different approach that learn to represent and optimize molecules in a continuous…

Quantitative Methods · Quantitative Biology 2020-11-17 Matthew Ragoza , Tomohide Masuda , David Ryan Koes

Despite exceptional predictive performance of Deep sequence models (DSMs), the main concern of their deployment centers around the lack of uncertainty awareness. In contrast, probabilistic models quantify the uncertainty associated with…

Machine Learning · Computer Science 2026-03-03 Wenlong Chen

Owing to its longevity and enormous information density, DNA, the molecule encoding biological information, has emerged as a promising archival storage medium. However, due to technological constraints, data can only be written onto many…

Emerging Technologies · Computer Science 2018-03-12 Reinhard Heckel , Gediminas Mikutis , Robert N. Grass

In several domains, data objects can be decomposed into sets of simpler objects. It is then natural to represent each object as the set of its components or parts. Many conventional machine learning algorithms are unable to process this…

Machine Learning · Computer Science 2020-03-03 Konstantinos Skianis , Giannis Nikolentzos , Stratis Limnios , Michalis Vazirgiannis

We propose a new abstraction set (SynopSet) that has a continuum of visual representations for the explanatory analysis of molecular dynamics simulations (MDS) in the DNA nanotechnology domain. By re-purposing the commonly used progress bar…

Quantitative Methods · Quantitative Biology 2022-05-04 Deng Luo , Alexandre Kouyoumdjian , Ondřej Strnad , Haichao Miao , Ivan Barišić , Ivan Viola

Motivation: Enhancers are important cis-regulatory elements that regulate a wide range of biological functions and enhance the transcription of target genes. Although many feature extraction methods have been proposed to improve the…

Genomics · Quantitative Biology 2023-07-18 Jiahao Li , Zhourun Wu , Wenhao Lin , Jiawei Luo , Jun Zhang , Qingcai Chen , Junjie Chen

With the rapid increase of available digital data, DNA storage is identified as a storage media with high density and capability of long-term preservation, especially for archival storage systems. However, the encoding density (i.e., how…

Emerging Technologies · Computer Science 2021-08-26 Bingzhe Li , Li Ou , David Du

Deep Learning (DL) aims at learning the \emph{meaningful representations}. A meaningful representation refers to the one that gives rise to significant performance improvement of associated Machine Learning (ML) tasks by replacing the raw…

Neural and Evolutionary Computing · Computer Science 2018-02-27 Yanan Sun , Gary G. Yen , Zhang Yi

Proteins perform critical processes in all living systems: converting solar energy into chemical energy, replicating DNA, as the basis of highly performant materials, sensing and much more. While an incredible range of functionality has…

Biomolecules · Quantitative Biology 2021-09-29 Leonardo V. Castorina , Rokas Petrenas , Kartic Subr , Christopher W. Wood
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