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Life can be viewed as a localized chemical system that sits on, or in the basin of attraction of, a metastable dynamical attractor state that remains out of equilibrium with the environment. Such a view of life allows that new living states…

Populations and Evolution · Quantitative Biology 2018-01-08 David A. Baum

Many models for the origin of life have focused on understanding how evolution can drive the refinement of a preexisting enzyme, such as the evolution of efficient replicase activity. Here we present a model for what was, arguably, an even…

Biomolecules · Quantitative Biology 2012-12-20 Sara Imari Walker , Martha A. Grover , Nicholas V. Hud

The evolution of complexity has been a central theme for Biology [2] and Artificial Life research [1]. It is generally agreed that complexity has increased in our universe, giving way to life, multi-cellularity, societies, and systems of…

Populations and Evolution · Quantitative Biology 2011-09-06 Carlos Gershenson , Tom Lenaerts

Reduction of information entropy along with ever-increasing complexity are among the key signatures of living matter. Understanding the onset of such behavior in early prebiotic world is essential for solving the problem of origins of life.…

Populations and Evolution · Quantitative Biology 2018-10-17 Alexei V. Tkachenko , Sergei Maslov

The evolution of complexity has been a central theme for Biology and Artificial Life (Bonner, 1988; Bedau et al., 2000). Complexification has been interpreted in different ways: as a process of diversification between evolving units…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Carlos Gershenson , Tom Lenaerts

Emergence and maintenance of polymers with complex sequences is a major question in the study of origins of life. To answer this, we studied a model polymerization reaction, where polymers are synthesized by stepwise ligation from two types…

Biological Physics · Physics 2018-09-19 Yoshiya J. Matsubara , Kunihiko Kaneko

One of the longest standing open problems in science is how life arises from non-living matter. If it is possible to measure this transition in the lab, then it might be possible to understand the physical mechanisms by which the emergence…

Biomolecules · Quantitative Biology 2026-02-23 Sara Imari Walker

Why are living systems complex? Why does the biosphere contain living beings with complexity features beyond those of the simplest replicators? What kind of evolutionary pressures result in more complex life forms? These are key questions…

Populations and Evolution · Quantitative Biology 2023-11-13 Seoane LF , Solé R

We propose a novel definition of life in terms of which its emergence in the universe is expected, and its ever-creative open-ended evolution is entailed by no law. Living organisms are Kantian Wholes that achieve Catalytic Closure,…

Populations and Evolution · Quantitative Biology 2024-04-11 Stuart Kauffman , Andrea Roli

Selection is central to biological evolution, yet there has been no general experimental framework for quantifying selection in chemical systems before life. Here we demonstrate that selection in a prebiological chemical system can be…

Molecular Networks · Quantitative Biology 2025-12-23 Michael Jirasek , Abhishek Sharma , Mary Wong , Jennifer Munro , Leroy Cronin

A mystery about the origins of life is which molecular structures $-$ and what spontaneous processes $-$ drove the autocatalytic transition from simple chemistry to biology? Using the HP lattice model of polymer sequence spaces leads to the…

Biomolecules · Quantitative Biology 2016-05-02 Elizaveta A Guseva , Ronald N Zuckermann , Ken A Dill

We propose a minimal model of the dynamics of diversity -- replicator equations with extinction, invasion and mutation. We numerically study the behavior of this simple model and show that it displays completely different behavior from the…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Kei Tokita , Ayumu Yasutomi

The rise of multicellularity in the early evolution of life represents a major challenge for evolutionary biology. Guidance for finding answers has emerged from disparate fields, from phylogenetics to modelling and synthetic biology, but…

Populations and Evolution · Quantitative Biology 2015-11-09 Salva Duran-Nebreda , Adriano Bonforti , Raul Montañez , Sergi Valverde , Ricard Solé

In order to make a case for or against a trend in the evolution of complexity in biological evolution, complexity needs to be both rigorously defined and measurable. A recent information-theoretic (but intuitively evident) definition…

Biological Physics · Physics 2016-09-08 Christoph Adami , Charles Ofria , Travis C. Collier

Evolution is often understood through genetic mutations driving changes in an organism's fitness, but there is potential to extend this understanding beyond the genetic code. We propose that natural products - complex molecules central to…

Populations and Evolution · Quantitative Biology 2024-09-11 Sebastian Pagel , Abhishek Sharma , Leroy Cronin

Since the time of Darwin, scientists have struggled to reconcile the evolution of biological forms in a universe determined by fixed laws. These laws underpin the origin of life, evolution, human culture and technology, as set by the…

One of the properties that make ecological systems so unique is the range of complex behavioural patterns that can be exhibited by even the simplest communities with only a few species. Much of this complexity is commonly attributed to…

Populations and Evolution · Quantitative Biology 2022-03-18 James Wilsenach , Pietro Landi , Cang Hui

A major aim of evolutionary biology is to explain the respective roles of adaptive versus non-adaptive changes in the evolution of complexity. While selection is certainly responsible for the spread and maintenance of complex phenotypes,…

Populations and Evolution · Quantitative Biology 2017-01-17 Thomas LaBar , Christoph Adami

Research investigating the origins of life usually focuses on exploring possible life-bearing chemistries in the pre-biotic Earth, or else on synthetic approaches. Little work has been done exploring fundamental issues concerning the…

Populations and Evolution · Quantitative Biology 2015-06-24 Christoph Adami

Recent years have witnessed the detection of an increasing number of complex organic molecules in interstellar space, some of them being of prebiotic interest. Disentangling the origin of interstellar prebiotic chemistry and its connection…

Astrophysics of Galaxies · Physics 2022-07-29 Miguel Garcia-Sanchez , Izaskun Jimenez-Serra , Fernando Puente-Sanchez , Jacobo Aguirre
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