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Accurately modeling time-continuous stochastic processes from irregular observations remains a significant challenge. In this paper, we leverage ideas from generative modeling of image data to push the boundary of time series generation.…

Numerical Analysis · Mathematics 2025-05-30 T. Jahn , J. Chemseddine , P. Hagemann , C. Wald , G. Steidl

Rare diseases affect a relatively small number of people, which limits investment in research for treatments and cures. Developing an efficient method for rare disease detection is a crucial first step towards subsequent clinical research.…

Machine Learning · Computer Science 2018-12-04 Wenyuan Li , Yunlong Wang , Yong Cai , Corey Arnold , Emily Zhao , Yilian Yuan

Understanding the dynamic nature of biological systems is fundamental to deciphering cellular behavior, developmental processes, and disease progression. Single-cell RNA sequencing (scRNA-seq) has provided static snapshots of gene…

Quantitative Methods · Quantitative Biology 2025-05-02 Zhenyi Zhang , Yuhao Sun , Qiangwei Peng , Tiejun Li , Peijie Zhou

The early identification and intervention of latent depression are of significant societal importance for mental health governance. While current automated detection methods based on social media have shown progress, their decision-making…

Quantitative Methods · Quantitative Biology 2025-12-17 Junwei Kuang , Jiaheng Xie , Zhijun Yan

Clinical outcome or severity prediction from medical images has largely focused on learning representations from single-timepoint or snapshot scans. It has been shown that disease progression can be better characterized by temporal imaging.…

Image and Video Processing · Electrical Eng. & Systems 2022-04-01 Aishik Konwer , Xuan Xu , Joseph Bae , Chao Chen , Prateek Prasanna

Background. Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo clinical changes. Yet, modeling changes over disease course from cohort data is challenging as the usual timescales are…

Accurate and reliable forecasting of epidemic incidences is critical for public health preparedness, yet it remains a challenging task due to complex nonlinear temporal dependencies and heterogeneous spatial interactions. Often, point…

Machine Learning · Statistics 2026-03-10 Rajdeep Pathak , Tanujit Chakraborty

Analyzing surgical workflow is crucial for surgical assistance robots to understand surgeries. With the understanding of the complete surgical workflow, the robots are able to assist the surgeons in intra-operative events, such as by giving…

Computer Vision and Pattern Recognition · Computer Science 2021-05-12 Yutong Ban , Guy Rosman , Thomas Ward , Daniel Hashimoto , Taisei Kondo , Hidekazu Iwaki , Ozanan Meireles , Daniela Rus

Generative models such as Generative Adversarial Networks (GANs) and Variational Autoencoders (VAEs) play an increasingly important role in medical image analysis. The latent spaces of these models often show semantically meaningful…

Image and Video Processing · Electrical Eng. & Systems 2022-07-21 Julian Schön , Raghavendra Selvan , Jens Petersen

Despite notable advancements, the integration of deep learning (DL) techniques into impactful clinical applications, particularly in the realm of digital histopathology, has been hindered by challenges associated with achieving robust…

Image and Video Processing · Electrical Eng. & Systems 2024-07-04 Sebastian Doerrich , Francesco Di Salvo , Christian Ledig

Self-supervised learning (SSL) is attractive for plant disease detection as it can exploit large collections of unlabeled leaf images, yet most existing SSL methods are built on CNNs or vision transformers that are poorly matched to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Abdullah Al Mamun , Miaohua Zhang , David Ahmedt-Aristizabal , Zeeshan Hayder , Mohammad Awrangjeb

In recent years, applying deep learning (DL) to assess structural damages has gained growing popularity in vision-based structural health monitoring (SHM). However, both data deficiency and class-imbalance hinder the wide adoption of DL in…

Machine Learning · Computer Science 2022-11-30 Yuqing Gao , Pengyuan Zhai , Khalid M. Mosalam

Generative models can produce synthetic patient records for analytical tasks when real data is unavailable or limited. However, current methods struggle with adhering to domain-specific knowledge and removing invalid data. We present…

Machine Learning · Computer Science 2023-12-22 Brandon Theodorou , Shrusti Jain , Cao Xiao , Jimeng Sun

Retrieval-augmented generation improves large language models by grounding outputs in external knowledge sources, reducing hallucinations and addressing knowledge cutoffs. However, standard embedding-based retrieval fails to capture the…

Information Retrieval · Computer Science 2025-12-23 Markus Ekvall , Ludvig Bergenstråhle , Patrick Truong , Ben Murrell , Joakim Lundeberg

Deep generative models trained with large amounts of unlabelled data have proven to be powerful within the domain of unsupervised learning. Many real life data sets contain a small amount of labelled data points, that are typically…

Machine Learning · Statistics 2017-04-04 Lars Maaløe , Marco Fraccaro , Ole Winther

Testing complex simulation models can be expensive and time consuming. Current state-of-the-art methods that explore this problem are fully-supervised; i.e. they require that all examples are labeled. On the other hand, the GenClu system…

Software Engineering · Computer Science 2023-12-04 Xiao Ling , Tim Menzies

Self-supervised learning (SSL) has recently emerged as a powerful approach to learning representations from large-scale unlabeled data, showing promising results in time series analysis. The self-supervised representation learning can be…

Machine Learning · Computer Science 2024-03-18 Ziyu Liu , Azadeh Alavi , Minyi Li , Xiang Zhang

Temporal networks are essential for modeling and understanding systems whose behavior varies in time, from social interactions to biological systems. Often, however, real-world data are prohibitively expensive to collect in a large scale or…

Social and Information Networks · Computer Science 2023-08-23 Antonio Longa , Giulia Cencetti , Sune Lehmann , Andrea Passerini , Bruno Lepri

High-throughput microarray and sequencing technology have been used to identify disease subtypes that could not be observed otherwise by using clinical variables alone. The classical unsupervised clustering strategy concerns primarily the…

Methodology · Statistics 2020-07-23 Peng Liu , Yusi Fang , Zhao Ren , Lu Tang , George C. Tseng

Small longitudinal clinical cohorts, common in maternal health, rare diseases, and early-phase trials, limit computational modeling: too few patients to train reliable models, yet too costly and slow to expand through additional enrollment.…

Machine Learning · Computer Science 2026-04-10 Jeffrey D. Varner , Maria Cristina Bravo , Carole McBride , Thomas Orfeo , Ira Bernstein
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