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This paper deals with the problem of estimating variables in nonlinear models for the spread of disease and its application to the COVID-19 epidemic. First unconstrained methods are revisited and they are shown to correspond to the…

Optimization and Control · Mathematics 2020-08-20 Mauricio C. de Oliveira

The mean field variational Bayes method is becoming increasingly popular in statistics and machine learning. Its iterative Coordinate Ascent Variational Inference algorithm has been widely applied to large scale Bayesian inference. See Blei…

Statistics Theory · Mathematics 2017-12-12 Anderson Y. Zhang , Harrison H. Zhou

Infectious disease modeling is used to forecast epidemics and assess the effectiveness of intervention strategies. Although the core assumption of mass-action models of homogeneously mixed population is often implausible, they are…

Physics and Society · Physics 2024-08-29 Thien-Minh Le , Jukka-Pekka Onnela

In the present work the spread of epidemic is studied over complex networks which are characterized by power law degree distribution of links and heterogeneous rate of disease transmission. The random allocation of epidemic transmission…

Physics and Society · Physics 2016-07-19 Vikram Sagar , Yi Zhao

Coalescent models are used to study the transmission dynamics of rapidly evolving pathogens from molecular sequence data obtained from infected individuals. However coalescent parameters, such as effective population size, offer limited…

Methodology · Statistics 2025-11-14 Isaac H. Goldstein , Julia A. Palacios

The epidemiology of pandemics is classically viewed using geographical and political borders; however, these artificial divisions can result in a misunderstanding of the current epidemiological state within a given region. To improve upon…

Populations and Evolution · Quantitative Biology 2023-11-28 David Lyver , Mihai Nica , Corentin Cot , Giacomo Cacciapaglia , Zahra Mohammadi , Edward W. Thommes , Monica-Gabriela Cojocaru

To reduce the biases of traditional survey-based methods, this paper proposes an epidemic model-based approach to inference the incubation period distribution of COVID-19 utilizing the publicly reported confirmed case number. We construct…

Populations and Evolution · Quantitative Biology 2020-07-23 Shiyang Lai , Tianqi Zhao , Ningyuan Fan

In recent studies, it has been shown that a cooperative interaction in a co-infection spread can lead to a discontinuous transition at a decreased threshold. Here, we investigate effects of immunization with a rate proportional to the…

Populations and Evolution · Quantitative Biology 2022-05-02 Adib Khazaee , Fakhteh Ghanbarnejad

A number of models in mathematical epidemiology have been developed to account for control measures such as vaccination or quarantine. However, COVID-19 has brought unprecedented social distancing measures, with a challenge on how to…

Populations and Evolution · Quantitative Biology 2021-09-07 Magdalena Djordjevic , Andjela Rodic , Igor Salom , Dusan Zigic , Ognjen Milicevic , Bojana Ilic , Marko Djordjevic

Dynamic properties of spreading infection through a heterogeneous population are studied numerically and analytically using a dynamic variant of Watts and Strogatz Small World Network-based stochastic Susceptible-Exposed-Infectious-Removed…

Populations and Evolution · Quantitative Biology 2019-06-28 O. Mosbah , N. Zekri , M. Mokhtari , S. Sahraoui

We have studied the dynamic evolution of the Covid-19 pandemic in Argentina. The marked heterogeneity in population density and the very extensive geography of the country becomes a challenge itself. Standard compartment models fail when…

Populations and Evolution · Quantitative Biology 2021-01-01 Nadia L. Barreiro , Tzype Govezensky , Pablo G. Bolcatto , Rafael A. Barrio

This paper investigates the dynamics of infectious diseases with a non-exponentially distributed infectious period. This is achieved by considering a multi-stage infection model on networks. Using pairwise approximation with a standard…

Physics and Society · Physics 2015-11-23 N. Sherborne , K. B. Blyuss , I. Z. Kiss

This research presents an advanced fractional-order compartmental model designed to delve into the complexities of COVID-19 transmission dynamics, specifically accounting for the influence of environmental pathogens on disease spread. By…

Populations and Evolution · Quantitative Biology 2024-07-09 Moein Khalighi , Faïçal Ndaïrou , Leo Lahti

As COVID-19 spread through the United States in 2020, states began to set up alert systems to inform policy decisions and serve as risk communication tools for the general public. Many of these systems, like in Ohio, included indicators…

Applications · Statistics 2023-05-12 David Kline , Ayaz Hyder , Enhao Liu , Michael Rayo , Samuel Malloy , Elisabeth Root

We propose a novel approach that integrates machine learning into compartmental disease modeling to predict the progression of COVID-19. Our model is explainable by design as it explicitly shows how different compartments evolve and it uses…

We tackle limitations of ordinary differential equation-driven Susceptible-Infections-Removed (SIR) models and their extensions that have recently be employed for epidemic nowcasting and forecasting. In particular, we deal with challenges…

Computation · Statistics 2026-02-10 Angelos Alexopoulos , Paul Birrell , Daniela De Angelis

The spread of an undesirable contact process, such as an infectious disease (e.g. COVID-19), is contained through testing and isolation of infected nodes. The temporal and spatial evolution of the process (along with containment through…

Machine Learning · Computer Science 2023-03-24 Xingran Chen , Hesam Nikpey , Jungyeol Kim , Saswati Sarkar , Shirin Saeedi-Bidokhti

Spatiotemporal modelling of infectious diseases such as COVID-19 involves using a variety of epidemiological metrics such as regional proportion of cases or regional positivity rates. Although observing their changes over time is critical…

We consider a flexible Bayesian evidence synthesis approach to model the age-specific transmission dynamics of COVID-19 based on daily mortality counts. The temporal evolution of transmission rates in populations containing multiple types…

We study sequential Bayesian inference in stochastic kinetic models with latent factors. Assuming continuous observation of all the reactions, our focus is on joint inference of the unknown reaction rates and the dynamic latent states,…

Computation · Statistics 2014-09-10 Junjing Lin , Michael Ludkovski