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The human heart is a sophisticated system composed of four cardiac chambers with distinct shapes, which function in a coordinated manner. Existing shape models of the heart mainly focus on the ventricular chambers and they are derived from…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Qiang Ma , Qingjie Meng , Yicheng Wu , Shuo Wang , Mengyun Qiao , Steven Niederer , Declan P. O'Regan , Paul M. Matthews , Wenjia Bai

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…

Delineation of anatomical structures is often the first step of many medical image analysis workflows. While convolutional neural networks achieve high performance, these do not incorporate anatomical shape information. We introduce a novel…

Image and Video Processing · Electrical Eng. & Systems 2023-10-18 Athira J Jacob , Puneet Sharma , Daniel Ruckert

A coupled map is suggested to investigate various spatial or temporal designs in biology: Several cells (or tissues) in an organ are considered as connected to each other in terms of some molecular diffusions or electrical potential…

General Physics · Physics 2011-06-07 Caglar Tuncay

Spatio-temporal (3D+t) generative modelling of cardiac shape and motion is crucial for understanding heart structure and function at population scale. Existing generative models for cardiac shape synthesis either adopt volumetric shape…

Image and Video Processing · Electrical Eng. & Systems 2026-05-05 Qiang Ma , Qingjie Meng , Mengyun Qiao , Paul M. Matthews , Declan P. O'Regan , Wenjia Bai

Generative modeling of anatomical structures plays a crucial role in virtual imaging trials, which allow researchers to perform studies without the costs and constraints inherent to in vivo and phantom studies. For clinical relevance,…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Bram de Wilde , Max T. Rietberg , Guillaume Lajoinie , Jelmer M. Wolterink

Deformable shape modeling approaches that describe objects in terms of their medial axis geometry (e.g., m-reps [Pizer et al., 2003]) yield rich geometrical features that can be useful for analyzing the shape of sheet-like biological…

Graphics · Computer Science 2019-03-04 Paul A. Yushkevich , Ahmed Aly , Jiancong Wang , Long Xie , Robert C. Gorman , Laurent Younes , Alison Pouch

Large prospective epidemiological studies acquire cardiovascular magnetic resonance (CMR) images for pre-symptomatic populations and follow these over time. To support this approach, fully automatic large-scale 3D analysis is essential. In…

Image and Video Processing · Electrical Eng. & Systems 2019-07-04 Rahman Attar , Marco Pereanez , Christopher Bowles , Stefan K. Piechnik , Stefan Neubauer , Steffen E. Petersen , Alejandro F. Frangi

Patient-specific cardiac modeling combines geometries of the heart derived from medical images and biophysical simulations to predict various aspects of cardiac function. However, generating simulation-suitable models of the heart from…

Image and Video Processing · Electrical Eng. & Systems 2023-11-09 Fanwei Kong , Shawn Shadden

We propose to learn a probabilistic motion model from a sequence of images for spatio-temporal registration. Our model encodes motion in a low-dimensional probabilistic space - the motion matrix - which enables various motion analysis tasks…

Computer Vision and Pattern Recognition · Computer Science 2021-02-02 Julian Krebs , Hervé Delingette , Nicholas Ayache , Tommaso Mansi

Many spatio-temporal data record the time of birth and death of individuals, along with their spatial trajectories during their lifetime, whether through continuous-time observations or discrete-time observations. Natural applications…

Probability · Mathematics 2021-07-14 Frédéric Lavancier , Ronan Le Guével

Cardiac arrhythmogenesis is governed by complex electromechanical interactions that are not directly observable in vivo, motivating the development of non-invasive computational approaches for reconstructing three-dimensional activation…

Medical Physics · Physics 2026-03-05 Nathan Dermul , Hans Dierckx

Spatiotemporal graph represents a crucial data structure where the nodes and edges are embedded in a geometric space and can evolve dynamically over time. Nowadays, spatiotemporal graph data is becoming increasingly popular and important,…

Machine Learning · Computer Science 2022-03-02 Yuanqi Du , Xiaojie Guo , Hengning Cao , Yanfang Ye , Liang Zhao

Statistical models used to estimate the spatio-temporal pattern in disease risk from areal unit data represent the risk surface for each time period with known covariates and a set of spatially smooth random effects. The latter act as a…

Applications · Statistics 2016-04-19 Alastair Rushworth , Duncan Lee , Christophe Sarran

The effect of heart geometry and anisotropy on cardiac re-entry dynamics and self-termination is studied here in anatomically realistic computer simulations of human foetal heart. 20 weeks of gestational age human foetal heart isotropic and…

Tissues and Organs · Quantitative Biology 2017-08-22 Irina V. Biktasheva , Richard A. Anderson , Arun V. Holden , Eleftheria Pervolaraki , Fengcai Wen

Patient-specific computational models of the heart are powerful tools for cardiovascular research and medicine, with demonstrated applications in treatment planning, device evaluation, and surgical decision-making. Yet constructing such…

Medical Physics · Physics 2026-04-21 Aaron L. Brown , Ju Liu , Daniel B. Ennis , Alison L. Marsden

A new model is suggested and used to mimic various spatial or temporal designs in biological or non biological formations where the focus is on the normal or irregular electrical signals coming from human heart (ECG) or brain (EEG). The…

Biological Physics · Physics 2008-07-08 Caglar Tuncay

Reentry around non-conducting ventricular scar tissue, which often causes lethal arrhythmias, is typically treated by rapid stimulation from an implantable defibrillator. However, the mechanisms of termination (success and failure) are…

Chaotic Dynamics · Physics 2007-05-23 Sitabhra Sinha , David J. Christini

Accurate motion estimation in cardiac computed tomography (CT) imaging is critical for assessing cardiac function and surgical planning. Data-driven methods have become the standard approach for dense motion estimation, but they rely on…

Image and Video Processing · Electrical Eng. & Systems 2025-07-23 Shahar Zuler , Gal Lifshitz , Hadar Averbuch-Elor , Dan Raviv

Learning spatial-temporal correspondences in cardiac motion from images is important for understanding the underlying dynamics of cardiac anatomical structures. Many methods explicitly impose smoothness constraints such as the…

Image and Video Processing · Electrical Eng. & Systems 2022-09-05 Xiaoran Zhang , Chenyu You , Shawn Ahn , Juntang Zhuang , Lawrence Staib , James Duncan