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Large Language Model (LLM) agents are increasingly deployed in complex, multi-step workflows involving planning, tool use, reflection, and interaction with external knowledge systems. These workflows generate rapidly expanding contexts that…

Artificial Intelligence · Computer Science 2025-12-22 Kamer Ali Yuksel

While deep learning has significantly advanced automatic plant disease detection through image-based classification, improving model explainability remains crucial for reliable disease detection. In this study, we apply the Automated…

Computer Vision and Pattern Recognition · Computer Science 2024-12-11 Jihen Amara , Birgitta König-Ries , Sheeba Samuel

Availability of research datasets is keystone for health and life science study reproducibility and scientific progress. Due to the heterogeneity and complexity of these data, a main challenge to be overcome by research data management…

Information Retrieval · Computer Science 2017-09-12 Douglas Teodoro , Luc Mottin , Julien Gobeill , Arnaud Gaudinat , Thérèse Vachon , Patrick Ruch

In medical practice, treatments are selected based on the expected causal effects on patient outcomes. Here, the gold standard for estimating causal effects are randomized controlled trials; however, such trials are costly and sometimes…

Machine Learning · Statistics 2023-01-24 Dennis Frauen , Tobias Hatt , Valentyn Melnychuk , Stefan Feuerriegel

Accurate prediction of outcomes is crucial for clinical decision-making and personalized patient care. Supervised machine learning algorithms, which are commonly used for outcome prediction in the medical domain, optimize for predictive…

Machine Learning · Computer Science 2026-02-09 Nithya Bhasker , Fiona R. Kolbinger , Susu Hu , Gitta Kutyniok , Stefanie Speidel

The pandemic has accelerated the pace at which COVID-19 scientific papers are published. In addition, the process of manually assigning semantic indexes to these papers by experts is even more time-consuming and overwhelming in the current…

Information Retrieval · Computer Science 2020-10-08 Nima Ebadi , Peyman Najafirad

AI tools in pathology have improved screening throughput, standardized quantification, and revealed prognostic patterns that inform treatment. However, adoption remains limited because most systems still lack the human-readable reasoning…

Artificial Intelligence · Computer Science 2025-11-18 Yunqi Hong , Johnson Kao , Liam Edwards , Nein-Tzu Liu , Chung-Yen Huang , Alex Oliveira-Kowaleski , Cho-Jui Hsieh , Neil Y. C. Lin

Experiments are the gold standard for causal inference. In many applications, experimental units can often be recruited or chosen sequentially, and the adaptive execution of such experiments may offer greatly improved inference of causal…

Methodology · Statistics 2023-06-14 Difan Song , Simon Mak , C. F. Jeff Wu

The recent surge of foundation models in computer vision and natural language processing opens up perspectives in utilizing multi-modal clinical data to train large models with strong generalizability. Yet pathological image datasets often…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Yunkun Zhang , Jin Gao , Mu Zhou , Xiaosong Wang , Yu Qiao , Shaoting Zhang , Dequan Wang

We present CASE, an open-source framework for adaptive participatory research and disease surveillance. Unlike traditional survey platforms with static branching logic, CASE uses an event-driven architecture that adjusts survey workflows in…

Software Engineering · Computer Science 2026-01-13 Marco Hirsch , Peter Hevesi , Paul Lukowicz

Whole slide image (WSI) analysis is gaining prominence within the medical imaging field. Recent advances in pathology foundation models have shown the potential to extract powerful feature representations from WSIs for downstream tasks.…

Computer Vision and Pattern Recognition · Computer Science 2024-11-18 Yanyan Huang , Weiqin Zhao , Yihang Chen , Yu Fu , Lequan Yu

With the increasing use of large language models (LLMs) for generating answers to biomedical questions, it is crucial to evaluate the quality of the generated answers and the references provided to support the facts in the generated…

Computation and Language · Computer Science 2026-02-10 Deepak Gupta , Davis Bartels , Dina Demner-Fushman

We present PULSE, a medical reasoning agent that combines a domain-tuned large language model with scientific literature retrieval to support diagnostic decision-making in complex real-world cases. To evaluate its capabilities, we curated a…

Computation and Language · Computer Science 2026-03-19 Zhongzhen Huang , Yan Ling , Hong Chen , Ye Feng , Li Wu , Linjie Mu , Shaoting Zhang , Xiaofan Zhang , Kun Qian , Xiaomu Li

We study how to learn treatment policies from multimodal electronic health records (EHRs) that consist of tabular data and clinical text. These policies can help physicians make better treatment decisions and allocate healthcare resources…

Machine Learning · Computer Science 2026-04-21 Henri Arno , Thomas Demeester

Growing polarization of the news media has been blamed for fanning disagreement, controversy and even violence. Early identification of polarized topics is thus an urgent matter that can help mitigate conflict. However, accurate measurement…

Computation and Language · Computer Science 2021-09-14 Zihao He , Negar Mokhberian , Antonio Camara , Andres Abeliuk , Kristina Lerman

In this paper, we introduce a new causal methodology that accounts for the rarity and frequency of events in observational studies based on their relevance to the underlying problem. Specifically, we propose a direct causal effect metric…

Artificial Intelligence · Computer Science 2025-02-28 Usef Faghihi , Amir Saki

Federated learning of causal estimands may greatly improve estimation efficiency by leveraging data from multiple study sites, but robustness to heterogeneity and model misspecifications is vital for ensuring validity. We develop a…

Methodology · Statistics 2023-10-06 Larry Han , Jue Hou , Kelly Cho , Rui Duan , Tianxi Cai

Drug recommendation requires a deep understanding of individual patient context, especially for complex conditions like Parkinson's disease. While LLMs possess broad medical knowledge, they fail to capture the subtle nuances of actual…

Computation and Language · Computer Science 2026-03-19 Chaeyoung Huh , Hyunmin Hwang , Jung Hwan Shin , Jinse Park , Jong Chul Ye

COVID-19 is a new pulmonary disease which is driving stress to the hospitals due to the large number of cases worldwide. Imaging of lungs can play a key role in monitoring of the healthy status. Non-contrast chest computed tomography (CT)…

We introduce a dataset for evidence/rationale extraction on an extreme multi-label classification task over long medical documents. One such task is Computer-Assisted Coding (CAC) which has improved significantly in recent years, thanks to…

Computation and Language · Computer Science 2023-07-11 Hua Cheng , Rana Jafari , April Russell , Russell Klopfer , Edmond Lu , Benjamin Striner , Matthew R. Gormley
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