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Large Language Model (LLM) agents have shown great potential in addressing real-world data science problems. LLM-driven data science agents promise to automate the entire machine learning pipeline, yet their real-world effectiveness remains…

Computation and Language · Computer Science 2025-10-09 Yixin Ou , Yujie Luo , Jingsheng Zheng , Lanning Wei , Zhuoyun Yu , Shuofei Qiao , Jintian Zhang , Da Zheng , Yuren Mao , Yunjun Gao , Huajun Chen , Ningyu Zhang

Advances in generative artificial intelligence are transforming how metal-organic frameworks (MOFs) are designed and discovered. This Perspective introduces the shift from laborious enumeration of MOF candidates to generative approaches…

Domain-aware machine learning (ML) models have been increasingly adopted for accelerating small molecule therapeutic design in the recent years. These models have been enabled by significant advancement in state-of-the-art artificial…

Machine Learning · Computer Science 2021-02-12 Rajendra P. Joshi , Neeraj Kumar

The automation of scientific discovery represents a critical milestone in Artificial Intelligence (AI) research. However, existing agentic systems for science suffer from two fundamental limitations: rigid, pre-programmed workflows that…

Artificial Intelligence · Computer Science 2025-10-20 Ed Li , Junyu Ren , Xintian Pan , Cat Yan , Chuanhao Li , Dirk Bergemann , Zhuoran Yang

Generative models and machine learning promise accelerated material discovery in MOFs for CO2 capture and water harvesting but face significant challenges navigating vast chemical spaces while ensuring synthetizability. Here, we present…

Building agents, systems that perceive and act upon their environment with a degree of autonomy, has long been a focus of AI research. This pursuit has recently become vastly more practical with the emergence of large language models (LLMs)…

Topology optimization can generate efficient structures, but designers often must manually translate qualitative intent, such as desired visual style, product experience, or manufacturability into solver settings that are not directly tied…

Artificial Intelligence · Computer Science 2026-05-22 Isabella A. Stewart , Hongrui Chen , Faez Ahmed

Researchers are investing substantial effort in developing powerful general-purpose agents, wherein Foundation Models are used as modules within agentic systems (e.g. Chain-of-Thought, Self-Reflection, Toolformer). However, the history of…

Artificial Intelligence · Computer Science 2025-03-04 Shengran Hu , Cong Lu , Jeff Clune

Much previous AI research has focused on developing monolithic models to maximize their intelligence, with the primary goal of enhancing performance on specific tasks. In contrast, this work attempts to study using LLM-based agents to…

Computation and Language · Computer Science 2026-02-10 Xiangyuan Xue , Zeyu Lu , Di Huang , Zidong Wang , Wanli Ouyang , Lei Bai

The construction industry is characterized by both high physical and psychological risks, yet supports of mental health remain limited. While advancements in artificial intelligence (AI), particularly large language models (LLMs), offer…

Human-Computer Interaction · Computer Science 2025-06-10 Fan Yang , Yuan Tian , Jiansong Zhang

Understanding and predicting the properties of inorganic materials is crucial for accelerating advancements in materials science and driving applications in energy, electronics, and beyond. Integrating material structure data with…

Artificial Intelligence · Computer Science 2025-04-29 Yingheng Tang , Wenbin Xu , Jie Cao , Weilu Gao , Steve Farrell , Benjamin Erichson , Michael W. Mahoney , Andy Nonaka , Zhi Yao

Data-driven artificial intelligence (AI) approaches are fundamentally transforming the discovery of new materials. Despite the unprecedented availability of materials data in the scientific literature, much of this information remains…

Artificial Intelligence · Computer Science 2026-01-29 Di Zhang , Xue Jia , Tran Ba Hung , Seong Hoon Jang , Linda Zhang , Ryuhei Sato , Yusuke Hashimoto , Toyoto Sato , Kiyoe Konno , Shin-ichi Orimo , Hao Li

The emergence of large language models (LLMs) opens new frontiers for unmanned aerial vehicle (UAVs), yet existing systems remain confined to predefined tasks due to hardware-software co-design challenges. This paper presents the first…

Robotics · Computer Science 2025-03-12 Ji Zhao , Xiao Lin

The development of modern civil industry, energy and information technology is inseparable from the rapid explorations of new materials, which are hampered by months to years of painstaking attempts, resulting in only a small fraction of…

Chemical Physics · Physics 2023-03-22 Zhilong Wang , Junfei Cai , An Chen , Yanqiang Han , Kehao Tao , Simin Ye , Shiwei Wang , Imran Ali , Jinjin Li

Optical design is the process of configuring optical elements to precisely manipulate light for high-fidelity imaging. It is inherently a highly non-convex optimization problem that relies heavily on human heuristic expertise and…

Machine Learning · Computer Science 2026-03-02 Yuyu Geng , Lei Sun , Yao Gao , Xinxin Hu , Zhonghua Yi , Xiaolong Qian , Weijian Hu , Jian Bai , Kaiwei Wang

The discovery of novel catalysts tailored for particular applications is a major challenge for the twenty-first century. Traditional methods for this include time-consuming and expensive experimental trial-and-error approaches in labs based…

Computation and Language · Computer Science 2026-05-29 Achuth Chandrasekhar , Janghoon Ock , Amir Barati Farimani

AI models underpin data-centric applications from image and text processing to scientific discovery in biology, physics, and chemistry. Yet developing them remains heavily manual, requiring practitioners to design architectures, build…

Artificial Intelligence · Computer Science 2026-05-28 Ruiyi Zhang , Peijia Qin , Qi Cao , Li Zhang , Pengtao Xie

Metal-organic frameworks (MOFs) offer a vast design space, and as such, computational simulations play a critical role in predicting their structural and physicochemical properties. However, MOF simulations remain difficult to access…

Artificial Intelligence · Computer Science 2026-04-01 Jaewoong Lee , Taeun Bae , Jihan Kim

Artificial Intelligence (AI) agents capable of autonomous learning and independent decision-making hold great promise for addressing complex challenges across various critical infrastructure domains, including transportation, energy…

Multiagent Systems · Computer Science 2025-07-02 Hepeng Li , Yuhong Liu , Jun Yan , Jie Gao , Xiaoou Yang

Autoresearch offers a flexible paradigm for automating scientific tasks, in which an AI agent proposes, implements, evaluates, and refines candidate solutions against a quantitative objective. Here, we use composition-based…

Materials Science · Physics 2026-05-15 Matteo Cobelli , Stefano Sanvito
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