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Lipid nanoparticles (LNPs) are among the most clinically mature platforms for nucleic acid delivery, yet designing lipids that are both effective and biologically safe remains a major bottleneck. In practical screening, toxicity is a…

Artificial Intelligence · Computer Science 2026-05-26 Leshu Li , An Lu , Haiyu Wang , Zhibin Feng , Conghui Duan , Qing Bao , Zongmin Zhao , Sai Qian Zhang

Large language models (LLMs) are catalyzing the development of autonomous AI research agents for scientific and engineering discovery. We present FM Agent, a novel and general-purpose multi-agent framework that leverages a synergistic…

LLM-based reasoning models have enabled the development of agentic systems that act as co-scientists, assisting in multi-step scientific analysis. However, evaluating these systems is challenging, as it requires realistic, end-to-end…

Machine Learning · Computer Science 2026-02-24 Siba Smarak Panigrahi , Jovana Videnović , Maria Brbić

Control system design is a crucial aspect of modern engineering with far-reaching applications across diverse sectors including aerospace, automotive systems, power grids, and robotics. Despite advances made by Large Language Models (LLMs)…

Systems and Control · Electrical Eng. & Systems 2024-10-29 Xingang Guo , Darioush Keivan , Usman Syed , Lianhui Qin , Huan Zhang , Geir Dullerud , Peter Seiler , Bin Hu

Data-driven scientific discovery requires the iterative integration of scientific domain knowledge, statistical expertise, and an understanding of data semantics to make nuanced analytical decisions, e.g., about which variables,…

Artificial Intelligence (AI) is accelerating the transformation of scientific research paradigms, not only enhancing research efficiency but also driving innovation. We introduce InternAgent, a unified closed-loop multi-agent framework to…

Humans solve problems by executing targeted plans, yet large language models (LLMs) remain unreliable for structured workflow execution. We propose RunAgent, a multi-agent plan execution platform that interprets natural-language plans while…

Machine Learning · Computer Science 2026-05-04 Arunabh Srivastava , Mohammad A. , Khojastepour , Srimat Chakradhar , Sennur Ulukus

Large language models (LLMs) and emerging agentic frameworks are beginning to transform single-cell biology by enabling natural-language reasoning, generative annotation, and multimodal data integration. However, progress remains fragmented…

Computation and Language · Computer Science 2025-11-25 Sajib Acharjee Dip , Adrika Zafor , Bikash Kumar Paul , Uddip Acharjee Shuvo , Muhit Islam Emon , Xuan Wang , Liqing Zhang

Scientific reasoning inherently demands integrating sophisticated toolkits to navigate domain-specific knowledge. Yet, current benchmarks largely overlook agents' ability to orchestrate tools for such rigorous workflows. To bridge this gap,…

Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic…

Artificial Intelligence · Computer Science 2025-10-14 Hongjie Zheng , Zesheng Shi , Ping Yi

Table reasoning, including tabular QA and fact verification, often depends on annotated data or complex data augmentation, limiting flexibility and generalization. LLMs, despite their versatility, often underperform compared to simple…

Artificial Intelligence · Computer Science 2025-11-19 Yiran Rex Ma

Large Language Models have recently shown impressive capabilities in reasoning and code generation, making them promising tools for natural language interfaces to relational databases. However, existing approaches often fail to generalize…

Databases · Computer Science 2026-02-03 Wenjia Jiang , Yiwei Wang , Boyan Han , Joey Tianyi Zhou , Chi Zhang

Large language models (LLMs) and agent techniques have brought a fundamental shift in the functionality and development paradigm of data analysis tasks (a.k.a LLM/Agent-as-Data-Analyst), demonstrating substantial impact across both academia…

Deep Research Agents are a prominent category of LLM-based agents. By autonomously orchestrating multistep web exploration, targeted retrieval, and higher-order synthesis, they transform vast amounts of online information into…

Computation and Language · Computer Science 2025-06-16 Mingxuan Du , Benfeng Xu , Chiwei Zhu , Xiaorui Wang , Zhendong Mao

We introduce a novel large language model (LLM)-driven agent framework, which iteratively refines queries and filters contextual evidence by leveraging dynamically evolving knowledge. A defining feature of the system is its decoupling of…

Artificial Intelligence · Computer Science 2025-04-02 Seyoung Song

Large language models (LLMs) have enabled remarkable advances in automated task-solving with multi-agent systems. However, most existing LLM-based multi-agent approaches rely on predefined agents to handle simple tasks, limiting the…

Artificial Intelligence · Computer Science 2024-05-01 Guangyao Chen , Siwei Dong , Yu Shu , Ge Zhang , Jaward Sesay , Börje F. Karlsson , Jie Fu , Yemin Shi

Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of genomic data that populates several online databases and repositories. Here, we…

Genomics · Quantitative Biology 2024-04-17 Mahnoor N. Gondal , Saad Ur Rehman Shah , Arul M. Chinnaiyan , Marcin Cieslik

Side-channel attacks exploit unintended information leakage from system behavior and continue to pose serious privacy risks in modern platforms. Despite extensive prior work, side-channel analysis remains largely manual and fragmented,…

Cryptography and Security · Computer Science 2026-05-19 Zhen Xu , Zihao Wang , Yuhua Sun , XiaoFeng Wang

Since its selection as the method of the year in 2013, single-cell technologies have become mature enough to provide answers to complex research questions. With the growth of single-cell profiling technologies, there has also been a…

Large language models excel at interpreting complex natural language instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as the "language of cellular…

Computation and Language · Computer Science 2025-01-16 Yin Fang , Xinle Deng , Kangwei Liu , Ningyu Zhang , Jingyang Qian , Penghui Yang , Xiaohui Fan , Huajun Chen
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