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This paper addresses optimal feedback selection for generic arbitrary pole placement of structured systems when each feedback edge is associated with a cost. Given a structured system and a feedback cost matrix, our aim is to find a…

Optimization and Control · Mathematics 2017-07-06 Shana Moothedath , Prasanna Chaporkar , Madhu N. Belur

We extend an hypergraph representation, introduced by Finkelstein and Roytberg, to unify dynamic programming algorithms in the context of RNA folding with pseudoknots. Classic applications of RNA dynamic programming energy minimization,…

Quantitative Methods · Quantitative Biology 2011-06-21 Yann Ponty , Cédric Saule

This paper demonstrates the usefulness of distributed local verification of proofs, as a tool for the design of self-stabilizing algorithms.In particular, it introduces a somewhat generalized notion of distributed local proofs, and utilizes…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-12-25 Amos Korman , Shay Kutten , Toshimitsu Masuzawa

Variational quantum algorithms provide a direct, physics-based approach to protein structure prediction, but their accuracy is limited by the coarse resolution of the energy landscapes generated on current noisy devices. We propose a hybrid…

Emerging Technologies · Computer Science 2025-10-09 Yuqi Zhang , Yuxin Yang , Feixiong Chen , Cheng-Chang Lu , Nima Saeidi , Samuel L. Volchenboum , Junhan Zhao , Siwei Chen , Weiwen Jiang , Qiang Guan

RNA design is the search for a sequence or set of sequences that will fold into predefined structures, also known as the inverse problem of RNA folding. While numerous RNA design methods have been invented to find sequences capable of…

Biomolecules · Quantitative Biology 2024-08-13 Tianshuo Zhou , Wei Yu Tang , David H. Mathews , Liang Huang

Nearest neighbor (NN) algorithms have been extensively used for missing data problems in recommender systems and sequential decision-making systems. Prior theoretical analysis has established favorable guarantees for NN when the underlying…

Machine Learning · Statistics 2025-09-03 Tathagata Sadhukhan , Manit Paul , Raaz Dwivedi

The soft bootstrap is an on-shell method to constrain the landscape of effective field theories (EFTs) of massless particles via the consistency of the low-energy S-matrix. Given assumptions on the on-shell data (particle spectra, linear…

High Energy Physics - Theory · Physics 2019-02-20 Henriette Elvang , Marios Hadjiantonis , Callum R. T. Jones , Shruti Paranjape

The folding pathway and rate coefficients of the folding of a knotted protein are calculated for a potential energy function with minimal energetic frustration. A kinetic transition network is constructed using the discrete path sampling…

Biomolecules · Quantitative Biology 2010-07-05 Michael C. Prentiss , David J. Wales , Peter G. Wolynes

We present a dual optimization concept of predicting optimal sequences as well as optimal folds of off-lattice protein models in the context of multi-scale modeling. We validate the utility of the recently introduced hidden-force Monte…

Biomolecules · Quantitative Biology 2015-02-20 István Kolossváry

Minimum Spanning Tree (MST) is an important graph algorithm that has wide ranging applications in the areas of computer networks, VLSI routing, wireless communications among others. Today virtually every computer is built out of multi-core…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-15 Suryanarayana Murthy Durbhakula

We give the first almost-linear time algorithm for computing the \emph{maximal $k$-edge-connected subgraphs} of an undirected unweighted graph for any constant $k$. More specifically, given an $n$-vertex $m$-edge graph $G=(V,E)$ and a…

Data Structures and Algorithms · Computer Science 2023-07-04 Thatchaphol Saranurak , Wuwei Yuan

Hardware accelerations of deep learning systems have been extensively investigated in industry and academia. The aim of this paper is to achieve ultra-high energy efficiency and performance for hardware implementations of deep neural…

Machine Learning · Computer Science 2018-02-20 Yanzhi Wang , Caiwen Ding , Zhe Li , Geng Yuan , Siyu Liao , Xiaolong Ma , Bo Yuan , Xuehai Qian , Jian Tang , Qinru Qiu , Xue Lin

Inferring probabilistic networks from data is a notoriously difficult task. Under various goodness-of-fit measures, finding an optimal network is NP-hard, even if restricted to polytrees of bounded in-degree. Polynomial-time algorithms are…

Data Structures and Algorithms · Computer Science 2012-08-16 Serge Gaspers , Mikko Koivisto , Mathieu Liedloff , Sebastian Ordyniak , Stefan Szeider

This paper introduces the notion of distributed verification without preprocessing. It focuses on the Minimum-weight Spanning Tree (MST) verification problem and establishes tight upper and lower bounds for the time and message complexities…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-12-16 Liah Kor , Amos Korman , David Peleg

We propose a new algorithm for the fast solution of large, sparse, symmetric positive-definite linear systems, spaND -- sparsified Nested Dissection. It is based on nested dissection, sparsification and low-rank compression. After…

Numerical Analysis · Mathematics 2020-01-28 Léopold Cambier , Chao Chen , Erik G Boman , Sivasankaran Rajamanickam , Raymond S. Tuminaro , Eric Darve

We examine what is an efficient and scalable nonlinear solver, with low work and memory complexity, for many classes of discretized partial differential equations (PDEs) - matrix-free Full multigrid (FMG) with a Full Approximation Storage…

Numerical Analysis · Mathematics 2023-06-07 Mark F. Adams

Submodular function minimization (SFM) and matroid intersection are fundamental discrete optimization problems with applications in many fields. It is well known that both of these can be solved making $\mathrm{poly}(N)$ queries to a…

Data Structures and Algorithms · Computer Science 2021-11-16 Deeparnab Chakrabarty , Yu Chen , Sanjeev Khanna

In the $k$-edge-connected spanning subgraph ($k$ECSS) problem, our goal is to compute a minimum-cost sub-network that is resilient against up to $k$ link failures: Given an $n$-node $m$-edge graph with a cost function on the edges, our goal…

We present an efficient method to mix well converged ab initio forces with simpler and faster ones in molecular dynamics. While the cheap forces are evaluated every time step, the converged ones correct the trajectory only every n time…

Materials Science · Physics 2009-11-10 E. Anglada , J. Junquera , J. M. Soler

In the recent past, neural architecture search (NAS) has attracted increasing attention from both academia and industries. Despite the steady stream of impressive empirical results, most existing NAS algorithms are computationally…

Computer Vision and Pattern Recognition · Computer Science 2020-11-30 Shengran Hu , Ran Cheng , Cheng He , Zhichao Lu