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Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Computers and Society · Computer Science 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

Large Language Models (LLMs) trained on extensive textual corpora have emerged as leading solutions for a broad array of Natural Language Processing (NLP) tasks. Despite their notable performance, these models are prone to certain…

Computation and Language · Computer Science 2023-07-25 Yufei Wang , Wanjun Zhong , Liangyou Li , Fei Mi , Xingshan Zeng , Wenyong Huang , Lifeng Shang , Xin Jiang , Qun Liu

Soft prompt tuning is a parameter-efficient method for adapting LLMs to specific tasks, but suffers from a lack of interpretability. Building on recent work on interpreting soft prompts (Ramati et al., 2024), we explore how training a…

Computation and Language · Computer Science 2026-05-28 Pitipat Kongsomjit , Suryansh Goyal , Jacob Whitehill

Large Language Models (LLMs) have revolutionized artificial intelligence, demonstrating remarkable computational power and linguistic capabilities. However, these models are inherently prone to various biases stemming from their training…

Computation and Language · Computer Science 2025-02-14 Riccardo Cantini , Giada Cosenza , Alessio Orsino , Domenico Talia

Large language models (LLMs) are widely used as zero-shot and few-shot classifiers, where task behaviour is largely controlled through prompting. A growing number of works have observed that LLMs are sensitive to prompt variations, with…

Computation and Language · Computer Science 2026-02-05 Branislav Pecher , Michal Spiegel , Robert Belanec , Jan Cegin

Large Language Models (LLMs) have shown capabilities close to human performance in various analytical tasks, leading researchers to use them for time and labor-intensive analyses. However, their capability to handle highly specialized and…

Computation and Language · Computer Science 2024-10-08 Alexander S. Choi , Syeda Sabrina Akter , JP Singh , Antonios Anastasopoulos

In the era of large language models (LLMs), code benchmarks have become an important research area in software engineering and are widely used by practitioners. These benchmarks evaluate the performance of LLMs on specific code-related…

Software Engineering · Computer Science 2025-06-24 Zhiyuan Pan , Xing Hu , Xin Xia , Xiaohu Yang

Large language Models (LLMs) are highly sensitive to variations in prompt formulation, which can significantly impact their ability to generate accurate responses. In this paper, we introduce a new task, Prompt Sensitivity Prediction, and a…

Computation and Language · Computer Science 2025-02-11 Amirhossein Razavi , Mina Soltangheis , Negar Arabzadeh , Sara Salamat , Morteza Zihayat , Ebrahim Bagheri

Large language models (LLMs) have demonstrated impressive performance across various domains. However, for clinical diagnosis, higher expectations are required for LLM's reliability and sensitivity: thinking like physicians and remaining…

Computation and Language · Computer Science 2025-04-21 Chenwei Yan , Xiangling Fu , Yuxuan Xiong , Tianyi Wang , Siu Cheung Hui , Ji Wu , Xien Liu

Large language models (LLMs) have been applied to tasks in healthcare, ranging from medical exam questions to responding to patient questions. With increasing institutional partnerships between companies producing LLMs and healthcare…

Computation and Language · Computer Science 2024-04-10 Jesutofunmi A. Omiye , Haiwen Gui , Shawheen J. Rezaei , James Zou , Roxana Daneshjou

Large language models (LLMs) have played a pivotal role in building communicative AI, yet they encounter the challenge of efficient updates. Model editing enables the manipulation of specific knowledge memories and the behavior of language…

Computation and Language · Computer Science 2024-10-28 Xinbei Ma , Tianjie Ju , Jiyang Qiu , Zhuosheng Zhang , Hai Zhao , Lifeng Liu , Yulong Wang

In the ongoing wave of impact driven by large language models (LLMs) like ChatGPT, the adaptation of LLMs to medical domain has emerged as a crucial research frontier. Since mainstream LLMs tend to be designed for general-purpose…

Computation and Language · Computer Science 2023-12-04 Issey Sukeda , Masahiro Suzuki , Hiroki Sakaji , Satoshi Kodera

Large Language Models (LLMs) are increasingly deployed for clinical reasoning tasks, which inherently require eliciting calibrated probabilistic beliefs based on available evidence. However, real-world clinical data are frequently…

Artificial Intelligence · Computer Science 2026-03-19 Yuta Kobayashi , Vincent Jeanselme , Shalmali Joshi

This research tests the role of Large Language Models (LLMs) as formal second opinion tools in professional decision-making, particularly focusing on complex medical cases where even experienced physicians seek peer consultation. The work…

Cryptography and Security · Computer Science 2024-10-29 David Noever

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

Computation and Language · Computer Science 2023-08-15 Thomas Savage , Ashwin Nayak , Robert Gallo , Ekanath Rangan , Jonathan H Chen

Warning: This paper contains examples of stereotypes and biases. Large Language Models (LLMs) exhibit considerable social biases, and various studies have tried to evaluate and mitigate these biases accurately. Previous studies use…

Computation and Language · Computer Science 2024-07-04 Rem Hida , Masahiro Kaneko , Naoaki Okazaki

Alignment with human preference prevents large language models (LLMs) from generating misleading or toxic content while requiring high-cost human feedback. Assuming resources of human annotation are limited, there are two different ways of…

Computation and Language · Computer Science 2024-04-02 Feifan Song , Bowen Yu , Hao Lang , Haiyang Yu , Fei Huang , Houfeng Wang , Yongbin Li

Instruction tuning is commonly assumed to endow language models with a domain-general ability to follow instructions, yet the underlying mechanism remains poorly understood. Does instruction-following rely on a universal mechanism or…

Artificial Intelligence · Computer Science 2026-04-08 Elisabetta Rocchetti , Alfio Ferrara

This paper explores the potential opportunities, risks, and challenges associated with the use of large language models (LLMs) in sports science and medicine. LLMs are large neural networks with transformer style architectures trained on…

Computation and Language · Computer Science 2023-05-09 Mark Connor , Michael O'Neill

The reasoning abilities of Large Language Models (LLMs) are becoming a central focus of study in NLP. In this paper, we consider the case of syllogistic reasoning, an area of deductive reasoning studied extensively in logic and cognitive…

Computation and Language · Computer Science 2024-10-18 Leonardo Bertolazzi , Albert Gatt , Raffaella Bernardi
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