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Statistical shape modeling (SSM) is an enabling quantitative tool to study anatomical shapes in various medical applications. However, directly using 3D images in these applications still has a long way to go. Recent deep learning methods…

Computer Vision and Pattern Recognition · Computer Science 2023-10-04 Abu Zahid Bin Aziz , Jadie Adams , Shireen Elhabian

Pretrained large language models (LLMs) are surprisingly effective at performing zero-shot tasks, including time-series forecasting. However, understanding the mechanisms behind such capabilities remains highly challenging due to the…

Machine Learning · Computer Science 2025-07-02 Toni J. B. Liu , Nicolas Boullé , Raphaël Sarfati , Christopher J. Earls

Simulation-based inference (SBI) is constantly in search of more expressive and efficient algorithms to accurately infer the parameters of complex simulation models. In line with this goal, we present consistency models for posterior…

Machine Learning · Computer Science 2024-11-05 Marvin Schmitt , Valentin Pratz , Ullrich Köthe , Paul-Christian Bürkner , Stefan T Radev

Real-world dynamical systems often consist of multiple stochastic subsystems that interact with each other. Modeling and forecasting the behavior of such dynamics are generally not easy, due to the inherent hardness in understanding the…

Machine Learning · Computer Science 2020-01-14 Fan Yang , Ling Chen , Fan Zhou , Yusong Gao , Wei Cao

Forecasting in the real world requires integrating structured time-series data with unstructured textual information, but existing methods are architecturally limited by fixed input/output horizons and are unable to model or quantify…

Machine Learning · Computer Science 2025-10-27 Sungjun Cho , Changho Shin , Suenggwan Jo , Xinya Yan , Shourjo Aditya Chaudhuri , Frederic Sala

Determining the different conformational states of a protein and the transition paths between them is key to fully understanding the relationship between biomolecular structure and function. This can be accomplished by sampling protein…

Biological Physics · Physics 2021-03-24 Venkata K. Ramaswamy , Chris G. Willcocks , Matteo T. Degiacomi

Diffusion models have demonstrated remarkable performance in generating high-dimensional samples across domains such as vision, language, and the sciences. Although continuous-state diffusion models have been extensively studied both…

Machine Learning · Computer Science 2026-02-17 Aadithya Srikanth , Mudit Gaur , Vaneet Aggarwal

Though large language models (LLMs) have enabled great success across a wide variety of tasks, they still appear to fall short of one of the loftier goals of artificial intelligence research: creating an artificial system that can adapt its…

Computation and Language · Computer Science 2026-05-04 Michael A. Lepori , Tal Linzen , Ann Yuan , Katja Filippova

Literatures in state space models focus on parametric inference and prediction, which fail if the state space model is not fully specified and the maximum likelihood estimation does not work. In this paper, we assume the state transition…

Statistics Theory · Mathematics 2020-12-15 Yunyi Zhang , Tingting Wang , Dimitris N. Politis

Markov state models (MSMs) have been successful in computing metastable states, slow relaxation timescales and associated structural changes, and stationary or kinetic experimental observables of complex molecules from large amounts of…

Chemical Physics · Physics 2015-06-17 Frank Noe , Hao Wu , Jan-Hendrik Prinz , Nuria Plattner

Machine learning approaches to spatiotemporal physical systems have primarily focused on next-frame prediction, with the goal of learning an accurate emulator for the system's evolution in time. However, these emulators are computationally…

Machine Learning · Computer Science 2026-03-16 Helen Qu , Rudy Morel , Michael McCabe , Alberto Bietti , François Lanusse , Shirley Ho , Yann LeCun

We propose a new method for spatio-temporal forecasting on arbitrarily distributed points. Assuming that the observed system follows an unknown partial differential equation, we derive a continuous-time model for the dynamics of the data…

Machine Learning · Computer Science 2022-03-18 Marten Lienen , Stephan Günnemann

State Space Models (SSMs) are powerful tools for modeling sequential data in computer vision and time series analysis domains. However, traditional SSMs are limited by fixed, one-dimensional sequential processing, which restricts their…

Machine Learning · Computer Science 2025-04-08 Nikola Zubić , Davide Scaramuzza

Regression models often fail to generalize effectively in regions characterized by highly imbalanced label distributions. Previous methods for deep imbalanced regression rely on gradient-based weight updates, which tend to overfit in…

Machine Learning · Computer Science 2024-11-21 Ismail Nejjar , Faez Ahmed , Olga Fink

We present a direct parametrization for continuous-time stochastic state-space models that ensures external stability via the stochastic bounded-real lemma. Our formulation facilitates the construction of probabilistic priors that enforce…

Methodology · Statistics 2025-09-23 Mohamad Al Ahdab , Zheng-Hua Tan , John Leth

State-space models (SSMs), such as Mamba (Gu & Dao, 2023), have been proposed as alternatives to Transformer networks in language modeling, by incorporating gating, convolutions, and input-dependent token selection to mitigate the quadratic…

Machine Learning · Computer Science 2024-04-26 Jongho Park , Jaeseung Park , Zheyang Xiong , Nayoung Lee , Jaewoong Cho , Samet Oymak , Kangwook Lee , Dimitris Papailiopoulos

The physical sciences are replete with dynamical systems that require the resolution of a wide range of length and time scales. This presents significant computational challenges since direct numerical simulation requires discretization at…

Machine Learning · Computer Science 2025-11-11 Andrew F. Ilersich , Prasanth B. Nair

The remarkable success of modern AI has been closely tied to scaling laws, yet the finite supply of high-quality data makes data efficiency--learning more from less--an increasingly important frontier. A model's inductive bias is a critical…

Machine Learning · Computer Science 2026-05-06 Qiyu Chen , Guozhang Chen

We examine the problem of learning mappings from state to state, suitable for use in a model-based reinforcement-learning setting, that simultaneously generalize to novel states and can capture stochastic transitions. We show that currently…

Machine Learning · Computer Science 2017-10-27 Yuhang Song , Christopher Grimm , Xianming Wang , Michael L. Littman

Mimicking human ability to forecast future positions or interpret complex interactions in urban scenarios, such as streets, shopping malls or squares, is essential to develop socially compliant robots or self-driving cars. Autonomous…

Computer Vision and Pattern Recognition · Computer Science 2019-09-20 Matteo Lisotto , Pasquale Coscia , Lamberto Ballan