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Heart attack remain one of the greatest contributors to mortality in the United States and globally. Patients admitted to the intensive care unit (ICU) with diagnosed heart attack (myocardial infarction or MI) are at higher risk of death.…

Machine Learning · Computer Science 2023-05-11 Munib Mesinovic , Peter Watkinson , Tingting Zhu

Background: During the early stages of hospital admission, clinicians must use limited information to make diagnostic and treatment decisions as patient acuity evolves. However, it is common that the time series vital sign information from…

Accurate early prediction of in-hospital mortality in intensive care units (ICUs) is essential for timely clinical intervention and efficient resource allocation. This study develops and evaluates machine learning models that integrate both…

Machine Learning · Computer Science 2025-10-22 Nursultan Mamatov , Philipp Kellmeyer

Augmentation of disease diagnosis and decision-making in healthcare with machine learning algorithms is gaining much impetus in recent years. In particular, in the current epidemiological situation caused by COVID-19 pandemic, swift and…

Computers and Society · Computer Science 2021-02-23 Leopold Franz , Yash Raj Shrestha , Bibek Paudel

In many clinical trials, individuals in different subgroups have experience differential treatment effects. This leads to individualized differences in treatment benefit. In this article, we introduce the general concept of predictive…

Methodology · Statistics 2018-07-11 Debashis Ghosh , Youngjoo Cho

Electronic medical records (EMR) contain longitudinal information about patients that can be used to analyze outcomes. Typically, studies on EMR data have worked with established variables that have already been acknowledged to be…

Machine Learning · Computer Science 2017-11-30 Prithwish Chakraborty , Vishrawas Gopalakrishnan , Sharon M. H. Alford , Faisal Farooq

Obesity is a major health problem, increasing the risk of various major chronic diseases, such as diabetes, cancer, and stroke. While the role of obesity identified by cross-sectional BMI recordings has been heavily studied, the role of BMI…

Machine Learning · Computer Science 2024-12-03 Md Mozaharul Mottalib , Jessica C Jones-Smith , Bethany Sheridan , Rahmatollah Beheshti

Early identification of patients at risk for clinical deterioration in the intensive care unit (ICU) remains a critical challenge. Delayed recognition of impending adverse events, including mortality, vasopressor initiation, and mechanical…

Machine Learning · Computer Science 2026-03-17 Binesh Sadanandan

Artificial intelligence holds strong potential to support clinical decision making in intensive care units where timely and accurate risk assessment is critical. However, many existing models focus on isolated outcomes or limited data…

Monitoring patients in ICU is a challenging and high-cost task. Hence, predicting the condition of patients during their ICU stay can help provide better acute care and plan the hospital's resources. There has been continuous progress in…

Computation and Language · Computer Science 2020-01-03 Swaraj Khadanga , Karan Aggarwal , Shafiq Joty , Jaideep Srivastava

Risk of suicide attempt varies over time. Understanding the importance of risk factors measured at a mental health visit can help clinicians evaluate future risk and provide appropriate care during the visit. In prediction settings where…

Predicting future clinical events from longitudinal electronic health records (EHRs) requires selecting plausible outcomes from a large and structured event space under sparse observations. While clinical coding systems provide hierarchical…

Machine Learning · Computer Science 2026-05-08 Zhan Qu , Michael Färber

Background and Objectives: Multidrug Resistance (MDR) is a critical global health issue, causing increased hospital stays, healthcare costs, and mortality. This study proposes an interpretable Machine Learning (ML) framework for MDR…

The solution here proposed can be used to conduct economic analysis in randomized clinical trials. It is based on a statistical approach and aims at calculating a revised version of the incremental costeffective ratio (ICER) in order to…

Applications · Statistics 2013-06-19 C. D'Urso

Given the limited pool of donor organs, accurate predictions of survival on the wait list and post transplantation are crucial for cardiac transplantation decisions and policy. However, current clinical risk scores do not yield accurate…

Applications · Statistics 2017-04-13 J. Yoon , W. R. Zame , A. Banerjee , M. Cadeiras , A. M. Alaa , M. van der Schaar

Unplanned intensive care unit (ICU) readmission rate is an important metric for evaluating the quality of hospital care. Efficient and accurate prediction of ICU readmission risk can not only help prevent patients from inappropriate…

Computation and Language · Computer Science 2022-01-10 Qiuhao Lu , Thien Huu Nguyen , Dejing Dou

Predicting (1) when the next hospital admission occurs and (2) what will happen in the next admission about a patient by mining electronic health record (EHR) data can provide granular readmission predictions to assist clinical decision…

Machine Learning · Computer Science 2021-02-05 Bhagya Hettige , Weiqing Wang , Yuan-Fang Li , Suong Le , Wray Buntine

Early recognition of clinical deterioration is one of the main steps for reducing inpatient morbidity and mortality. The challenging task of clinical deterioration identification in hospitals lies in the intense daily routines of healthcare…

Dynamic assessment of mortality risk in the intensive care unit (ICU) can be used to stratify patients, inform about treatment effectiveness or serve as part of an early-warning system. Static risk scoring systems, such as APACHE or SAPS,…

Machine Learning · Statistics 2020-11-03 Jonathan Heitz , Joanna Ficek , Martin Faltys , Tobias M. Merz , Gunnar Rätsch , Matthias Hüser

When training clinical prediction models from electronic health records (EHRs), a key concern should be a model's ability to sustain performance over time when deployed, even as care practices, database systems, and population demographics…

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