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Key objectives in conditional molecular generation include ensuring chemical validity, aligning generated molecules with target properties, promoting structural diversity, and enabling efficient sampling for discovery. Recent advances in…

This paper introduces a new probabilistic architecture called Sum-Product Graphical Model (SPGM). SPGMs combine traits from Sum-Product Networks (SPNs) and Graphical Models (GMs): Like SPNs, SPGMs always enable tractable inference using a…

Machine Learning · Statistics 2017-08-23 Mattia Desana , Christoph Schnörr

3D generative shape modeling is a fundamental research area in computer vision and interactive computer graphics, with many real-world applications. This paper investigates the novel problem of generating 3D shape point cloud geometry from…

Computer Vision and Pattern Recognition · Computer Science 2020-07-17 Kaichun Mo , He Wang , Xinchen Yan , Leonidas J. Guibas

Deep generative models have achieved remarkable success in various data domains, including images, time series, and natural languages. There remain, however, substantial challenges for combinatorial structures, including graphs. One of the…

Machine Learning · Computer Science 2018-09-21 Tengfei Ma , Jie Chen , Cao Xiao

With the development of graph applications, generative models for graphs have been more crucial. Classically, stochastic models that generate graphs with a pre-defined probability of edges and nodes have been studied. Recently, some models…

Machine Learning · Computer Science 2023-04-07 Shohei Nakazawa , Yoshiki Sato , Kenji Nakagawa , Sho Tsugawa , Kohei Watabe

Graph generation is a critical task in numerous domains, including molecular design and social network analysis, due to its ability to model complex relationships and structured data. While most modern graph generative models utilize…

Machine Learning · Computer Science 2025-06-04 Xiaohui Chen , Yinkai Wang , Jiaxing He , Yuanqi Du , Soha Hassoun , Xiaolin Xu , Li-Ping Liu

Recent data-efficient molecular generation approaches exploit graph grammars to introduce interpretability into the generative models. However, grammar learning therein relies on expert annotation or unreliable heuristics for algorithmic…

Artificial Intelligence · Computer Science 2025-05-30 Michael Sun , Weize Yuan , Gang Liu , Wojciech Matusik , Jie Chen

We introduce Graph-Induced Sum-Product Networks (GSPNs), a new probabilistic framework for graph representation learning that can tractably answer probabilistic queries. Inspired by the computational trees induced by vertices in the context…

Machine Learning · Computer Science 2024-02-19 Federico Errica , Mathias Niepert

Personalized review generation (PRG) aims to automatically produce review text reflecting user preference, which is a challenging natural language generation task. Most of previous studies do not explicitly model factual description of…

Computation and Language · Computer Science 2020-10-06 Junyi Li , Siqing Li , Wayne Xin Zhao , Gaole He , Zhicheng Wei , Nicholas Jing Yuan , Ji-Rong Wen

Two-stage stochastic programs (2SPs) are important tools for making decisions under uncertainty. Decision-makers use contextual information to generate a set of scenarios to represent the true conditional distribution. However, the number…

Optimization and Control · Mathematics 2025-02-11 David Islip , Roy H. Kwon , Sanghyeon Bae , Woo Chang Kim

Generative recommendation (GR) is an emerging paradigm that tokenizes items into discrete tokens and learns to autoregressively generate the next tokens as predictions. While this token-generation paradigm is expected to surpass traditional…

Information Retrieval · Computer Science 2025-11-25 Yijie Ding , Jiacheng Li , Julian McAuley , Yupeng Hou

Graph Neural Networks (GNNs) have been widely employed for feature representation learning in molecular graphs. Therefore, it is crucial to enhance the expressiveness of feature representation to ensure the effectiveness of GNNs. However, a…

Machine Learning · Computer Science 2024-09-16 Chengyu Yao , Hong Huang , Hang Gao , Fengge Wu , Haiming Chen , Junsuo Zhao

We address the problem of any-code completion - generating a missing piece of source code in a given program without any restriction on the vocabulary or structure. We introduce a new approach to any-code completion that leverages the…

Machine Learning · Computer Science 2020-07-30 Uri Alon , Roy Sadaka , Omer Levy , Eran Yahav

Generating molecules that bind to specific proteins is an important but challenging task in drug discovery. Previous works usually generate atoms in an auto-regressive way, where element types and 3D coordinates of atoms are generated one…

Biomolecules · Quantitative Biology 2024-07-16 Haitao Lin , Yufei Huang , Odin Zhang , Siqi Ma , Meng Liu , Xuanjing Li , Lirong Wu , Jishui Wang , Tingjun Hou , Stan Z. Li

In materials science, the challenge of rapid prototyping materials with desired properties often involves extensive experimentation to find suitable microstructures. Additionally, finding microstructures for given properties is typically an…

Machine Learning · Computer Science 2024-05-22 Sébastien Bompas , Stefan Sandfeld

The task of deducing three-dimensional molecular configurations from their two-dimensional graph representations holds paramount importance in the fields of computational chemistry and pharmaceutical development. The rapid advancement of…

Biomolecules · Quantitative Biology 2025-01-09 Bobin Yang , Jie Deng , Zhenghan Chen , Ruoxue Wu

We introduce the Graph Mixture Density Networks, a new family of machine learning models that can fit multimodal output distributions conditioned on graphs of arbitrary topology. By combining ideas from mixture models and graph…

Machine Learning · Computer Science 2021-06-28 Federico Errica , Davide Bacciu , Alessio Micheli

Generative models trained on internet-scale data are capable of generating novel and realistic texts, images, and videos. A natural next question is whether these models can advance science, for example by generating novel stable materials.…

Machine Learning · Computer Science 2024-06-05 Sherry Yang , KwangHwan Cho , Amil Merchant , Pieter Abbeel , Dale Schuurmans , Igor Mordatch , Ekin Dogus Cubuk

Training generative models that capture rich semantics of the data and interpreting the latent representations encoded by such models are very important problems in un-/self-supervised learning. In this work, we provide a simple algorithm…

Machine Learning · Computer Science 2024-09-02 Samuel C. Hoffman , Payel Das , Karthikeyan Shanmugam , Kahini Wadhawan , Prasanna Sattigeri

Graphs are ubiquitous data structures for representing interactions between entities. With an emphasis on the use of graphs to represent chemical molecules, we explore the task of learning to generate graphs that conform to a distribution…

Machine Learning · Computer Science 2019-03-08 Qi Liu , Miltiadis Allamanis , Marc Brockschmidt , Alexander L. Gaunt
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