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Medical image segmentation methods are generally designed as fully-supervised to guarantee model performance, which require a significant amount of expert annotated samples that are high-cost and laborious. Semi-supervised image…

Computer Vision and Pattern Recognition · Computer Science 2023-10-10 Xiangyu Zhao , Zengxin Qi , Sheng Wang , Qian Wang , Xuehai Wu , Ying Mao , Lichi Zhang

We study the performance of risk-controlling prediction sets (RCPS), an empirical risk minimization-based formulation of conformal prediction, with a single trajectory of temporally correlated data from an unknown stochastic dynamical…

Machine Learning · Computer Science 2024-06-04 Brian Lee , Nikolai Matni

Lung cancer is the leading cause of cancer related mortality by a significant margin. While new technologies, such as image segmentation, have been paramount to improved detection and earlier diagnoses, there are still significant…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Marguerite B. Basta , Sarfaraz Hussein , Hsiang Hsu , Flavio P. Calmon

Renal Cell Carcinoma is typically asymptomatic at the early stages for many patients. This leads to a late diagnosis of the tumor, where the curability likelihood is lower, and makes the mortality rate of Renal Cell Carcinoma high, with…

Computer Vision and Pattern Recognition · Computer Science 2025-12-17 Mohamad Mohamad , Francesco Ponzio , Santa Di Cataldo , Damien Ambrosetti , Xavier Descombes

Radiotherapy treatment planning is a challenging large-scale optimization problem plagued by uncertainty. Following the robust optimization methodology, we propose a novel, spatially based uncertainty set for robust modeling of radiotherapy…

Optimization and Control · Mathematics 2024-05-28 Noam Goldberg , Mark P. Langer , Shimrit Shtern

In many real-world problems, predictions are leveraged to monitor and control cyber-physical systems, demanding guarantees on the satisfaction of reliability and safety requirements. However, predictions are inherently uncertain, and…

Information Theory · Computer Science 2023-10-17 Matteo Zecchin , Sangwoo Park , Osvaldo Simeone

Recent radiomic studies have witnessed promising performance of deep learning techniques in learning radiomic features and fusing multimodal imaging data. Most existing deep learning based radiomic studies build predictive models in a…

Computer Vision and Pattern Recognition · Computer Science 2019-01-08 Hongming Li , Pamela Boimel , James Janopaul-Naylor , Haoyu Zhong , Ying Xiao , Edgar Ben-Josef , Yong Fan

Subgroup analyses of randomized controlled trials (RCTs) constitute an important component of the drug development process in precision medicine. In particular, subgroup analyses of early-stage trials often influence the design and…

Methodology · Statistics 2025-02-12 Daniel Schwartz , Riddhiman Saha , Steffen Ventz , Lorenzo Trippa

Annual low dose computed tomography (CT) lung screening is currently advised for individuals at high risk of lung cancer (e.g., heavy smokers between 55 and 80 years old). The recommended screening practice significantly reduces all-cause…

Computer Vision and Pattern Recognition · Computer Science 2020-02-18 Riqiang Gao , Lingfeng Li , Yucheng Tang , Sanja L. Antic , Alexis B. Paulson , Yuankai Huo , Kim L. Sandler , Pierre P. Massion , Bennett A. Landman

Control of nonlinear distributed parameter systems (DPS) under uncertainty is a meaningful task for many industrial processes. However, both intrinsic uncertainty and high dimensionality of DPS require intensive computations, while…

Optimization and Control · Mathematics 2024-10-17 Min Tao , Ioannis Zacharopoulos , Constantinos Theodoropoulos

Reliable uncertainty quantification is essential for deploying machine learning systems in high-stakes domains. Conformal prediction provides distribution-free coverage guarantees but often produces overly large prediction sets, limiting…

Machine Learning · Computer Science 2026-04-28 Yunpeng Xu , Wenge Guo , Zhi Wei

Objectives: High-grade serous ovarian carcinoma (HGSOC) is typically diagnosed at an advanced stage with extensive peritoneal metastases, making treatment challenging. Neoadjuvant chemotherapy (NACT) is often used to reduce tumor burden…

Accurate prediction of future risk and disease progression in sepsis is clinically important for early warning and timely intervention in intensive care. However, short-window sepsis prediction remains challenging, because shorter…

Machine Learning · Computer Science 2026-04-17 Honglin Guo , Rihao Chang , He Jiao , Weizhi Nie , Zhongheng Zhang , Yuehao Shen

Objectives: Approximately 30% of non-metastatic anal squamous cell carcinoma (ASCC) patients will experience recurrence after chemoradiotherapy (CRT), and currently available clinical variables are poor predictors of treatment response. We…

Computer Vision and Pattern Recognition · Computer Science 2023-09-07 Shanshan Tang , Kai Wang , David Hein , Gloria Lin , Nina N. Sanford , Jing Wang

A reliable locoregional recurrence (LRR) prediction model is important for the personalized management of head and neck cancers (HNC) patients. This work aims to develop a delta-radiomics feature-based multi-classifier, multi-objective, and…

Medical Physics · Physics 2023-05-10 Kai Wang , Michael Dohopolski , Qiongwen Zhang , David Sher , Jing Wang

Radiology report generation (RRG) is commonly formulated as a single-path generation task, where a multimodal large language model (MLLM) produces one decoded report as the final output. While recent progress has largely been driven by…

Computation and Language · Computer Science 2026-05-29 Xi Zhang , Yingshu Li , Zaiqiao Meng , Jake Lever , Edmond S. L. Ho

Distributional regression aims at estimating the conditional distribution of a targetvariable given explanatory co-variates. It is a crucial tool for forecasting whena precise uncertainty quantification is required. A popular methodology…

Statistics Theory · Mathematics 2024-11-22 Clément Dombry , Ahmed Zaoui

Lung cancer is the leading cause for cancer related deaths. As such, there is an urgent need for a streamlined process that can allow radiologists to provide diagnosis with greater efficiency and accuracy. A powerful tool to do this is…

Computer Vision and Pattern Recognition · Computer Science 2017-03-29 Devinder Kumar , Mohammad Javad Shafiee , Audrey G. Chung , Farzad Khalvati , Masoom A. Haider , Alexander Wong

Background and Objective: Non-invasively predicting the risk of cancer metastasis before surgery plays an essential role in determining optimal treatment methods for cancer patients (including who can benefit from neoadjuvant chemotherapy).…

Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…

Medical Physics · Physics 2025-06-26 Stefanos Achlatis , Efstratios Gavves , Jan-Jakob Sonke