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The rapidly emerging field of computational pathology has the potential to enable objective diagnosis, therapeutic response prediction and identification of new morphological features of clinical relevance. However, deep learning-based…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Ming Y. Lu , Drew F. K. Williamson , Tiffany Y. Chen , Richard J. Chen , Matteo Barbieri , Faisal Mahmood

In forensic facial comparison, questioned-source images are usually captured in uncontrolled environments, with non-uniform lighting, and from non-cooperative subjects. The poor quality of such material usually compromises their value as…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Rafael Oliveira Ribeiro , João C. R. Neves , Arnout C. C. Ruifrok , Flavio de Barros Vidal

Computational cytology faces two major challenges: i) instance-level labels are unreliable and prohibitively costly to obtain, ii) witness rates are extremely low. We propose SLAM-AGS, a Slide-Label-Aware Multitask pretraining framework…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Marco Acerbis , Swarnadip Chatterjee , Christophe Avenel , Joakim Lindblad

Foundation models have substantially advanced computational pathology by learning transferable visual representations from large histological datasets, yet their performance varies widely across tasks due to differences in training data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Wenhui Lei , Yusheng Tan , Anqi Li , Hanyu Chen , Hengrui Tian , Ruiying Li , Zhengqun Jiang , Fang Yan , Xiaofan Zhang , Shaoting Zhang

There exist numerous diagnostic tasks in pathology. Conventional computational pathology formulates and tackles them as independent and individual image classification problems, thereby resulting in computational inefficiency and high…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Anh Tien Nguyen , Keunho Byeon , Kyungeun Kim , Boram Song , Seoung Wan Chae , Jin Tae Kwak

Remarkable strides in computational pathology have been made in the task-agnostic foundation model that advances the performance of a wide array of downstream clinical tasks. Despite the promising performance, there are still several…

The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning…

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…

Digital pathology is revolutionizing the field of pathology by enabling the digitization, storage, and analysis of tissue samples as whole slide images (WSIs). WSIs are gigapixel files that capture the intricate details of tissue samples,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-10 S. Hemati , Krishna R. Kalari , H. R. Tizhoosh

Semantic segmentation is an essential component of medical image analysis research, with recent deep learning algorithms offering out-of-the-box applicability across diverse datasets. Despite these advancements, segmentation failures remain…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Maximilian Zenk , David Zimmerer , Fabian Isensee , Jeremias Traub , Tobias Norajitra , Paul F. Jäger , Klaus Maier-Hein

Whole slide images (WSIs) are the gold standard for pathological diagnosis and sub-typing. Current main-stream two-step frameworks employ offline feature encoders trained without domain-specific knowledge. Among them, attention-based…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Mingrui Ma , Chentao Li , Pan Huang , Jing Qin

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

The federated learning paradigm is wellsuited for the field of medical image analysis, as it can effectively cope with machine learning on isolated multicenter data while protecting the privacy of participating parties. However, current…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Zhekai Zhou , Guibo Luo , Mingzhi Chen , Zhenyu Weng , Yuesheng Zhu

To handle the large scale of whole slide images in computational pathology, most approaches first tessellate the images into smaller patches, extract features from these patches, and finally aggregate the feature vectors with…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Benedikt Roth , Valentin Koch , Sophia J. Wagner , Julia A. Schnabel , Carsten Marr , Tingying Peng

Multimodal evidence is critical in computational pathology: gigapixel whole slide images capture tumor morphology, while patient-level clinical descriptors preserve complementary context for prognosis. Integrating such heterogeneous signals…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Chengying She , Chengwei Chen , Xinran Zhang , Ben Wang , Lizhuang Liu , Chengwei Shao , Yun Bian

Federated learning (FL) enables collaborative model training across institutions without sharing sensitive data, making it an attractive solution for medical imaging tasks. However, traditional FL methods, such as Federated Averaging…

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

The use of self-supervised learning (SSL) to train pathology foundation models has increased substantially in the past few years. Notably, several models trained on large quantities of clinical data have been made publicly available in…

Automatic integration of whole slide images (WSIs) and gene expression profiles has demonstrated substantial potential in precision clinical diagnosis and cancer progression studies. However, most existing studies focus on individual gene…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Junzhuo Liu , Xuemei Du , Daniel Reisenbuchler , Ye Chen , Markus Eckstein , Christian Matek , Friedrich Feuerhake , Dorit Merhof