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Differential Diagnosis (DDx) is the process of identifying the most likely medical condition among the possible pathologies through the process of elimination based on evidence. An automated process that narrows a large set of pathologies…

Machine Learning · Computer Science 2023-12-05 Mohammad Mahmudul Alam , Edward Raff , Tim Oates , Cynthia Matuszek

The latest large language models (LLMs) such as ChatGPT, exhibit strong capabilities in automated mental health analysis. However, existing relevant studies bear several limitations, including inadequate evaluations, lack of prompting…

Computation and Language · Computer Science 2024-10-03 Kailai Yang , Shaoxiong Ji , Tianlin Zhang , Qianqian Xie , Ziyan Kuang , Sophia Ananiadou

The field of medical diagnosis has undergone a significant transformation with the advent of large language models (LLMs), yet the challenges of interpretability within these models remain largely unaddressed. This study introduces…

Computation and Language · Computer Science 2024-09-17 Junying Chen , Chi Gui , Anningzhe Gao , Ke Ji , Xidong Wang , Xiang Wan , Benyou Wang

Medical dialogue systems have attracted growing research attention as they have the potential to provide rapid diagnoses, treatment plans, and health consultations. In medical dialogues, a proper diagnosis is crucial as it establishes the…

Computation and Language · Computer Science 2024-01-15 Kaishuai Xu , Wenjun Hou , Yi Cheng , Jian Wang , Wenjie Li

Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios.…

Computation and Language · Computer Science 2026-01-06 Qipeng Wang , Rui Sheng , Yafei Li , Huamin Qu , Yushi Sun , Min Zhu

Medical Decision-Making (MDM) is a multi-faceted process that requires clinicians to assess complex multi-modal patient data patient, often collaboratively. Large Language Models (LLMs) promise to streamline this process by synthesizing…

Despite rare diseases affecting 1 in 10 Americans, their differential diagnosis remains challenging. Due to their impressive recall abilities, large language models (LLMs) have been recently explored for differential diagnosis. Existing…

Artificial Intelligence · Computer Science 2026-01-21 Zilal Eiz AlDin , John Wu , Jeffrey Paul Fung , Jennifer King , Mya Watts , Lauren ONeill , Adam Richard Cross , Jimeng Sun

Large Language Models (LLMs) demonstrate strong generalization and reasoning abilities, making them well-suited for complex decision-making tasks such as medical consultation (MC). However, existing LLM-based methods often fail to capture…

Computation and Language · Computer Science 2025-10-13 Zhihao Jia , Mingyi Jia , Junwen Duan , Jianxin Wang

Large language models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence technology which is rapidly evolving and promises to aid in medical diagnosis. However, the correctness and the accuracy of their returns has…

Computation and Language · Computer Science 2024-02-07 Dimitrios P. Panagoulias , Maria Virvou , George A. Tsihrintzis

Neural networks (NNs) achieve outstanding performance in many domains; however, their decision processes are often opaque and their inference can be computationally expensive in resource-constrained environments. We recently proposed…

Machine Learning · Computer Science 2025-05-30 Chang Yue , Niraj K. Jha

Mental health disorders represent a burgeoning global public health challenge. While Large Language Models (LLMs) have demonstrated potential in psychiatric assessment, their clinical utility is severely constrained by benchmarks that lack…

Artificial Intelligence · Computer Science 2026-02-04 Xiao Sun , Yuming Yang , Junnan Zhu , Jiang Zhong , Xinyu Zhou , Kaiwen Wei

Large Language Model (LLM)-based systems present new opportunities for autonomous health monitoring in sensor-rich industrial environments. This study explores the potential of LLMs to detect and classify faults directly from sensor data,…

Artificial Intelligence · Computer Science 2025-09-30 Xian Yeow Lee , Lasitha Vidyaratne , Ahmed Farahat , Chetan Gupta

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

Computation and Language · Computer Science 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

The integration of tabular data from diverse sources is often hindered by inconsistencies in formatting and representation, posing significant challenges for data analysts and personal digital assistants. Existing methods for automating…

Databases · Computer Science 2025-08-20 Arash Dargahi Nobari , Davood Rafiei

Automated depression diagnosis aims to analyze multimodal information from interview videos to predict participants' depression scores. Previous studies often lack clear explanations of how these scores were determined, limiting their…

Artificial Intelligence · Computer Science 2026-03-19 Wei Zhang , Juan Chen , En Zhu , Wenhong Cheng , YunPeng Li , Yanbo J. Wang

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

Computation and Language · Computer Science 2023-08-15 Thomas Savage , Ashwin Nayak , Robert Gallo , Ekanath Rangan , Jonathan H Chen

Structured data offers a sophisticated mechanism for the organization of information. Existing methodologies for the text-serialization of structured data in the context of large language models fail to adequately address the heterogeneity…

Computation and Language · Computer Science 2024-02-20 YiQiu Guo , Yuchen Yang , Ya Zhang , Yu Wang , Yanfeng Wang

Dynamic data-driven Digital Twins (DDTs) can enable informed decision-making and provide an optimisation platform for the underlying system. By leveraging principles of Dynamic Data-Driven Applications Systems (DDDAS), DDTs can formulate…

Depression remains widely underdiagnosed and undertreated because stigma and subjective symptom ratings hinder reliable screening. To address this challenge, we propose a coarse-to-fine, multi-stage framework that leverages large language…

Artificial Intelligence · Computer Science 2026-04-14 Shiyu Teng , Jiaqing Liu , Hao Sun , Yu Li , Shurong Chai , Ruibo Hou , Tomoko Tateyama , Lanfen Lin , Yen-Wei Chen

Automatic diagnosis is a significant application of AI in healthcare, where diagnoses are generated based on the symptom description of patients. Previous works have approached this task directly by modeling the relationship between the…

Computation and Language · Computer Science 2024-01-30 Haochun Wang , Sendong Zhao , Zewen Qiang , Nuwa Xi , Bing Qin , Ting Liu