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Accurate assessment of left atrial fibrosis in patients with atrial fibrillation relies on high-quality 3D late gadolinium enhancement (LGE) MRI images. However, obtaining such images is challenging due to patient motion, changing breathing…

Image and Video Processing · Electrical Eng. & Systems 2024-07-11 K M Arefeen Sultan , Benjamin Orkild , Alan Morris , Eugene Kholmovski , Erik Bieging , Eugene Kwan , Ravi Ranjan , Ed DiBella , Shireen Elhabian

High-quality Late Gadolinium Enhancement (LGE) MRI can be helpful for atrial fibrillation management, yet scan quality is frequently compromised by patient motion, irregular breathing, and suboptimal image acquisition timing. While Multiple…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 K M Arefeen Sultan , Kaysen Hansen , Benjamin Orkild , Alan Morris , Eugene Kholmovski , Erik Bieging , Eugene Kwan , Ravi Ranjan , Ed DiBella , Shireen Elhabian

Multi-instance learning is common for computer vision tasks, especially in biomedical image processing. Traditional methods for multi-instance learning focus on designing feature aggregation methods and multi-instance classifiers, where the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-18 Yanlun Tu , Houchao Lei , Wei Long , Yang Yang

Fine-grained classification of whole slide images (WSIs) is essential in precision oncology, enabling precise cancer diagnosis and personalized treatment strategies. The core of this task involves distinguishing subtle morphological…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Cheng Jin , Luyang Luo , Huangjing Lin , Jun Hou , Hao Chen

Atrial fibrillation (AF) is the most prevalent form of cardiac arrhythmia and is associated with increased morbidity and mortality. The effectiveness of current clinical interventions for AF is often limited by an incomplete understanding…

Image and Video Processing · Electrical Eng. & Systems 2024-09-25 Lucas Beveridge , Le Zhang

Multiple instance learning (MIL) is a robust paradigm for whole-slide pathological image (WSI) analysis, processing gigapixel-resolution images with slide-level labels. As pioneering efforts, attention-based MIL (ABMIL) and its variants are…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Linghan Cai , Shenjin Huang , Ye Zhang , Jinpeng Lu , Yongbing Zhang

Multiple Instance Learning (MIL) and transformers are increasingly popular in histopathology Whole Slide Image (WSI) classification. However, unlike human pathologists who selectively observe specific regions of histopathology tissues under…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Conghao Xiong , Hao Chen , Joseph J. Y. Sung , Irwin King

Atrial Fibrillation (AF) is characterized by rapid, irregular heartbeats, and can lead to fatal complications such as heart failure. The disease is divided into two sub-types based on severity, which can be automatically classified through…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Weihang Dai , Xiaomeng Li , Taihui Yu , Di Zhao , Jun Shen , Kwang-Ting Cheng

Late gadolinium enhancement magnetic resonance imaging (LGE MRI) is commonly used to visualize and quantify left atrial (LA) scars. The position and extent of scars provide important information of the pathophysiology and progression of…

Computer Vision and Pattern Recognition · Computer Science 2022-01-11 Lei Li , Veronika A. Zimmer , Julia A. Schnabel , Xiahai Zhuang

Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag are independent samples from a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-19 Yunan Wu , Francisco M. Castro-Macías , Pablo Morales-Álvarez , Rafael Molina , Aggelos K. Katsaggelos

Multiple Instance Learning (MIL) is increasingly being used as a support tool within clinical settings for pathological diagnosis decisions, achieving high performance and removing the annotation burden. However, existing approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Sungrae Hong , Kyungeun Kim , Juhyeon Kim , Sol Lee , Jisu Shin , Chanjae Song , Mun Yong Yi

Multiple instance learning (MIL) is a supervised learning methodology that aims to allow models to learn instance class labels from bag class labels, where a bag is defined to contain multiple instances. MIL is gaining traction for learning…

Computer Vision and Pattern Recognition · Computer Science 2019-11-14 Samuel W. Remedios , Zihao Wu , Camilo Bermudez , Cailey I. Kerley , Snehashis Roy , Mayur B. Patel , John A. Butman , Bennett A. Landman , Dzung L. Pham

Accurate cardiac computing, analysis and modeling from multi-modality images are important for the diagnosis and treatment of cardiac disease. Late gadolinium enhancement magnetic resonance imaging (LGE MRI) is a promising technique to…

Image and Video Processing · Electrical Eng. & Systems 2021-11-10 Lei Li , Fuping Wu , Sihang Wang , Xiahai Zhuang

Whole body magnetic resonance imaging (WB-MRI) is the recommended modality for diagnosis of multiple myeloma (MM). WB-MRI is used to detect sites of disease across the entire skeletal system, but it requires significant expertise and is…

Purpose: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is correlated with increased morbidity and mortality. It is associated with atrial fibrosis, which may be assessed non-invasively using late gadolinium-enhanced…

Computer Vision and Pattern Recognition · Computer Science 2018-07-04 Guang Yang , Xiahai Zhuang , Habib Khan , Shouvik Haldar , Eva Nyktari , Lei Li , Rick Wage , Xujiong Ye , Greg Slabaugh , Raad Mohiaddin , Tom Wong , Jennifer Keegan , David Firmin

Magnetic resonance (MR) imaging offers a wide variety of imaging techniques. A large amount of data is created per examination which needs to be checked for sufficient quality in order to derive a meaningful diagnosis. This is a manual…

Late Gadolinium Enhanced Cardiac MRI (LGE-CMRI) for detecting atrial scars in atrial fibrillation (AF) patients has recently emerged as a promising technique to stratify patients, guide ablation therapy and predict treatment success.…

Computer Vision and Pattern Recognition · Computer Science 2018-06-13 Jun Chen , Guang Yang , Zhifan Gao , Hao Ni , Elsa Angelini , Raad Mohiaddin , Tom Wong , Yanping Zhang , Xiuquan Du , Heye Zhang , Jennifer Keegan , David Firmin

In healthcare, multi-organ system diseases pose unique and significant challenges as they impact multiple physiological systems concurrently, demanding complex and coordinated treatment strategies. Despite recent advancements in the AI…

Artificial Intelligence · Computer Science 2025-08-08 Daniel J. Tan , Qianyi Xu , Kay Choong See , Dilruk Perera , Mengling Feng

Multi-instance learning (MIL) is an effective paradigm for whole-slide pathological images (WSIs) classification to handle the gigapixel resolution and slide-level label. Prevailing MIL methods primarily focus on improving the feature…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Tiancheng Lin , Zhimiao Yu , Hongyu Hu , Yi Xu , Chang Wen Chen

Multiple instance learning (MIL) is an effective and widely used approach for weakly supervised machine learning. In histopathology, MIL models have achieved remarkable success in tasks like tumor detection, biomarker prediction, and…

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