Related papers: Quantifying "just-right" APC inactivation for colo…
Glioblastoma is the most malignant type of central nervous system tumor with GBM subtypes cleaved based on molecular level gene alterations. These alterations are also happened to affect the histology. Thus, it can cause visible changes in…
Purpose. - Radiotherapy is an important treatment for prostate cancer.During treatment sessions, bladder and rectal repletion is difficult to quantify and cannot be measured with a single and initial CT scan acquisition. Some methods, such…
Pacreatic ductal adenocarcinoma (PDAC) remains one of the most lethal forms of cancer, with a five-year survival rate below 10% primarily due to late detection. This research develops and validates a deep learning framework for early PDAC…
The application of natural language processing (NLP) to cancer pathology reports has been focused on detecting cancer cases, largely ignoring precancerous cases. Improving the characterization of precancerous adenomas assists in developing…
Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a fundamental problem in the biology of apoptosis and has implications for apoptosis…
Adaptive therapy (AT) is designed to postpone the emergence of drug resistance by exploiting evolutionary competition among tumor subclones. Most mathematical models of AT assume a binary population structure of drug-sensitive and…
Purpose: To evaluate the cumulative radiobiological impact of daily Megavoltage Cone-Beam Computed Tomography (MV-CBCT) imaging dose based on Normal Tissue Complication Probability (NTCP) and Excess Absolute Risk (EAR) of secondary…
The goals in clinical and cohort studies often include evaluation of the association of a time-dependent binary treatment or exposure with a survival outcome. Recently, several impactful studies targeted the association between…
Purpose: This study explores the feasibility of dose-escalated proton beam therapy (dPBT) for Locally Advanced Pancreatic Cancer (LAPC) patients by modeling common patient scenarios using current clinically-adopted practices. Methods: Five…
Computational pathology (CoPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CoPath that are annotated with extensive histological…
Background: Radiotherapy outcomes are usually predicted using the Linear Quadratic model. However, this model does not integrate complex features of tumor growth, in particular cell cycle regulation. Methods: In this paper, we propose a…
Anticancer peptides (ACPs) are a class of molecules that have gained significant attention in the field of cancer research and therapy. ACPs are short chains of amino acids, the building blocks of proteins, and they possess the ability to…
Colorectal cancer is one of fatal cancer worldwide. Colonoscopy is the standard treatment for examination, localization, and removal of colorectal polyps. However, it has been shown that the miss-rate of colorectal polyps during colonoscopy…
Cancer is known as a disease mainly caused by gene alterations. Discovery of mutated driver pathways or gene sets is becoming an important step to understand molecular mechanisms of carcinogenesis. However, systematically investigating…
Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral…
Artificial intelligence systems show promise to aid in the di- agnostic pathway of prostate cancer (PC), by supporting radiologists in interpreting magnetic resonance images (MRI) of the prostate. Most MRI-based systems are designed to…
Identifying patient characteristics that influence the rate of colorectal polyp recurrence can provide important insights into which patients are at higher risk for recurrence. We used natural language processing to extract polyp…
The uncontrolled and unstructured growth of brain cells is known as brain tumor, which has one of the highest mortality rates among diseases from all types of cancers. Due to limited diagnostic and treatment capabilities, they pose…
Breast cancer is a common and deadly disease, but it is often curable when diagnosed early. While most countries have large-scale screening programs, there is no consensus on a single globally accepted guideline for breast cancer screening.…
One of the key characteristics of cancer cells is an increased phenotypic plasticity, driven by underlying genetic and epigenetic perturbations. However, at a systems-level it is unclear how these perturbations give rise to the observed…