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In this paper we consider a model based on branching process theory for the proliferation and the dissemination network of T cells in the adaptive immune response. A multi-type Galton Watson branching process is assumed as the basic…

Quantitative Methods · Quantitative Biology 2015-06-09 Alessandro Boianelli , Antonio Vicino

Coupling diffusion process of signaling molecules with nonlinear interactions of intracellular processes and cellular growth/transformation leads to a system of reaction-diffusion equations coupled with ordinary differential equations…

Analysis of PDEs · Mathematics 2013-11-08 Anna Marciniak-Czochra , Madoka Nakayama , Izumi Takagi

Complex behaviour in many systems arises from the stochastic interactions of spatially distributed particles or agents. Stochastic reaction-diffusion processes are widely used to model such behaviour in disciplines ranging from biology to…

Statistical Mechanics · Physics 2016-08-23 David Schnoerr , Ramon Grima , Guido Sanguinetti

We performed an extensive numerical study of a two-dimensional reaction-diffusion system of the activator-inhibitor type in which domain patterns can form. We showed that both multidomain and labyrinthine patterns may form spontaneously as…

patt-sol · Physics 2016-09-08 C. B. Muratov , V. V. Osipov

In this paper we consider mathematical modeling of the dynamics of self-organized patterning of spatially confined human embryonic stem cells (hESCs) treated with BMP4 (gastruloids) described in recent experimental works. In the first part…

Analysis of PDEs · Mathematics 2021-01-12 Prajakta Bedekar , Ilya Timofeyev , Aryeh Warmflash , Misha Perepelitsa

Mass-conserving reaction-diffusion systems with bistable nonlinearity are useful models for studying cell polarity formation, which is a key process in cell division and differentiation. We rigorously show the existence and stability of…

Analysis of PDEs · Mathematics 2025-05-23 Masataka Kuwamura , Takashi Teramoto , Hideo Ikeda

Microscopic models of reaction-diffusion processes on the cell membrane can link local spatiotemporal effects to macroscopic self-organized patterns often observed on the membrane. Simulation schemes based on the microscopic lattice method…

Subcellular Processes · Quantitative Biology 2019-04-24 Wei-Xiang Chew , Kazunari Kaizu , Masaki Watabe , Sithi V. Muniandy , Koichi Takahashi , Satya N. V. Arjunan

Daily, are reported systems in nature that present anomalous diffusion phenomena due to irregularities of medium, traps or reactions process. In this scenario, the diffusion with traps or localised--reactions emerge through various…

Statistical Mechanics · Physics 2019-05-01 Maike A. F. dos Santos

Spatio-temporal extensions of familiar compartment models for disease transmission incorporating diffusive behavior, or interactions between individuals at separate locations, are explored. The models considered have the character of…

Biological Physics · Physics 2022-06-28 Joseph Rudnick , David Jasnow , Jorge Vinals

Reaction-diffusion (Turing) systems are fundamental to the formation of spatial patterns in nature and engineering. These systems are governed by a set of non-linear partial differential equations containing parameters that determine the…

Machine Learning · Computer Science 2022-11-28 Jordon Kho , Winston Koh , Jian Cheng Wong , Pao-Hsiung Chiu , Chin Chun Ooi

The motion of a eukaryotic cell presents a variety of interesting and challenging problems from both a modeling and a computational perspective. The processes span many spatial scales (from molecular to tissue) as well as disparate time…

Cell Behavior · Quantitative Biology 2010-11-25 Ben Vanderlei , James J. Feng , Leah Edelstein-Keshet

The reversible A <-> B reaction-diffusion process, when species A and B are initially mixed and diffuse with different diffusion coefficients, is investigated using the boundary layer function method. It is assumed that the ratio of the…

Statistical Mechanics · Physics 2008-10-22 M. Sinder , V. Sokolovsky , J. Pelleg

We developed simulation methodology to assess eventual therapeutic efficiency of exogenous multiparametric changes in a four-component cellular system described by the system of ordinary differential equations. The method is numerically…

Tissues and Organs · Quantitative Biology 2018-06-05 Denis Horváth , Branislav Brutovsky

Turing patterns are a central paradigm for describing spatial patterns in nature. The corresponding theory of reaction-diffusion dynamics combines ideal diffusion with nonlinear reactions, resulting in patterns when species diffuse at…

Biological Physics · Physics 2026-01-28 Cathelijne ter Burg , David Zwicker

This paper is concerned with analysis of coupled fractional reaction-diffusion equations. It provides analytical comparison for the fractional and regular reaction-diffusion systems. As an example, the reaction-diffusion model with cubic…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Vasyl Gafiychuk , Bohdan Datsko , Vitaliy Meleshko

This study connects two methods for modeling reaction times (RTs) in choice tasks: (1) the first-hitting time of a simple diffusion model with a single barrier, representing the cognitive process leading to a response, and (2) Generalized…

Methodology · Statistics 2025-10-20 Mauricio Tejo , Cristian Meza , Fernando Marmolejo-Ramos

By considering the master equation of the partially asymmetric diffusion process on a one-dimensional lattice, the most general boundary condition (i.e. interactions) for the multi-species reaction-diffusion processes is considered.…

Statistical Mechanics · Physics 2009-11-11 M. Alimohammadi , Y. Naimi

We consider a continuous-space and continuous-time diffusion process under resetting with memory. A particle resets to a position chosen from its trajectory in the past according to a memory kernel. Depending on the form of the memory…

Statistical Mechanics · Physics 2017-11-29 Denis Boyer , Martin R. Evans , Satya N. Majumdar

Reaction-diffusion processes on networked systems have received mounting attention in the past two decades, and the corresponding theory of network dynamics has been continuously enriched with the advancement of network science. Recently,…

Pattern Formation and Solitons · Physics 2025-04-30 Junyuan Shi , Linhe Zhu

Recent experimental evidence suggests that acute myeloid leukemias may originate from multiple clones of malignant cells. Nevertheless it is not known how the observed clones may differ with respect to cell properties such as proliferation…

Tissues and Organs · Quantitative Biology 2014-10-07 Thomas Stiehl , Natalia Baran , Anthony D. Ho , Anna Marciniak-Czochra