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Predictive modeling using structural magnetic resonance imaging (MRI) data is a prominent approach to study brain-aging. Machine learning algorithms and feature extraction methods have been employed to improve predictions and explore…

Machine Learning · Computer Science 2025-01-20 Georgios Antonopoulos , Shammi More , Simon B. Eickhoff , Federico Raimondo , Kaustubh R. Patil

Deep learning has become a powerful tool for medical image analysis; however, conventional Convolutional Neural Networks (CNNs) often fail to capture the fine-grained and complex features critical for accurate diagnosis. To address this…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Zahid Ullah , Minki Hong , Tahir Mahmood , Jihie Kim

Accurate estimation of biological brain age from three dimensional (3D) T$_1$-weighted magnetic resonance imaging (MRI) is a critical imaging biomarker for identifying accelerated aging associated with neurodegenerative diseases. Effective…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Mehreen Kanwal , Yunsik Son

Myelination plays an important role in the neurological development of infant brain and MRI can visualize the myelination extension as T1 high and T2 low signal intensity at white matter. We tried to construct a convolutional neural network…

Deep learning techniques have demonstrated great potential for accurately estimating brain age by analyzing Magnetic Resonance Imaging (MRI) data from healthy individuals. However, current methods for brain age estimation often directly…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Fanzhe Yan , Gang Yang , Yu Li , Aiping Liu , Xun Chen

Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain…

Image and Video Processing · Electrical Eng. & Systems 2020-04-07 Sheng Liu , Chhavi Yadav , Carlos Fernandez-Granda , Narges Razavian

Resting-state functional MRI (rs-fMRI) scans hold the potential to serve as a diagnostic or prognostic tool for a wide variety of conditions, such as autism, Alzheimer's disease, and stroke. While a growing number of studies have…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Meenakshi Khosla , Keith Jamison , Amy Kuceyeski , Mert Sabuncu

Imaging findings inconsistent with those expected at specific chronological age ranges may serve as early indicators of neurological disorders and increased mortality risk. Estimation of chronological age, and deviations from expected…

Brain age is a critical measure that reflects the biological ageing process of the brain. The gap between brain age and chronological age, referred to as brain PAD (Predicted Age Difference), has been utilized to investigate…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Lemuel Puglisi , Alessia Rondinella , Linda De Meo , Francesco Guarnera , Sebastiano Battiato , Daniele Ravì

A three-dimensional convolutional neural network was developed to classify T1-weighted brain MRI scans as healthy or Alzheimer. The network comprises 3D convolution, pooling, batch normalization, dense ReLU layers, and a sigmoid output.…

Image and Video Processing · Electrical Eng. & Systems 2025-06-18 Thien Nhan Vo , Bac Nam Ho

In this work, we develop an attention convolutional neural network (CNN) to segment brain tumors from Magnetic Resonance Images (MRI). Further, we predict the survival rate using various machine learning methods. We adopt a 3D UNet…

Image and Video Processing · Electrical Eng. & Systems 2021-04-05 Mobarakol Islam , Vibashan VS , V Jeya Maria Jose , Navodini Wijethilake , Uppal Utkarsh , Hongliang Ren

Multi-organ segmentation is one of most successful applications of deep learning in medical image analysis. Deep convolutional neural nets (CNNs) have shown great promise in achieving clinically applicable image segmentation performance on…

Image and Video Processing · Electrical Eng. & Systems 2020-12-18 Hao Tang , Xingwei Liu , Kun Han , Shanlin Sun , Narisu Bai , Xuming Chen , Huang Qian , Yong Liu , Xiaohui Xie

Deep learning algorithms for predicting neuroimaging data have shown considerable promise in various applications. Prior work has demonstrated that deep learning models that take advantage of the data's 3D structure can outperform standard…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Yuda Bi , Anees Abrol , Zening Fu , Jiayu Chen , Jingyu Liu , Vince Calhoun

Background: Brain maturation and aging involve significant microstructural changes, resulting in functional and cognitive alterations. Quantitative MRI (qMRI) can measure this evolution, distinguishing the physiological effects of normal…

Generating realistic MRIs to accurately predict future changes in the structure of brain is an invaluable tool for clinicians in assessing clinical outcomes and analysing the disease progression at the patient level. However, current…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Mattia Litrico , Francesco Guarnera , Mario Valerio Giuffrida , Daniele Ravì , Sebastiano Battiato

Age is one of the major known risk factors for Alzheimer's Disease (AD). Detecting AD early is crucial for effective treatment and preventing irreversible brain damage. Brain age, a measure derived from brain imaging reflecting structural…

Image and Video Processing · Electrical Eng. & Systems 2024-05-07 Jay Shah , Md Mahfuzur Rahman Siddiquee , Yi Su , Teresa Wu , Baoxin Li

The human brain undergoes dynamic, potentially pathology-driven, structural changes throughout a lifespan. Longitudinal Magnetic Resonance Imaging (MRI) and other neuroimaging data are valuable for characterizing trajectories of change…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Agampreet Aulakh , Nils D. Forkert , Matthias Wilms

Automatic segmentation of brain MR images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is critical for tissue volumetric analysis and cortical surface reconstruction. Due to dramatic structural and appearance…

Image and Video Processing · Electrical Eng. & Systems 2023-01-05 Xiaoyang Chen , Jinjian Wu , Wenjiao Lyu , Yicheng Zou , Kim-Han Thung , Siyuan Liu , Ye Wu , Sahar Ahmad , Pew-Thian Yap

The accurate quantification of brain age from MRI has emerged as an important biomarker of brain health. However, existing approaches are often restricted to narrow age ranges and single-modality MRI data, limiting their capacity to capture…

Image and Video Processing · Electrical Eng. & Systems 2026-04-21 Dingyi Zhang , Ruiying Liu , Yun Wang

Automatic methods for measuring normalized regional brain volumes from MRI data are a key tool to help in the objective diagnostic and follow-up of many neurological diseases. To estimate such regional brain volumes, the intracranial cavity…