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Supervised deep learning methods for segmentation require large amounts of labelled training data, without which they are prone to overfitting, not generalizing well to unseen images. In practice, obtaining a large number of annotations…

Computer Vision and Pattern Recognition · Computer Science 2019-03-01 Krishna Chaitanya , Neerav Karani , Christian Baumgartner , Olivio Donati , Anton Becker , Ender Konukoglu

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). However, existing approaches typically rely on pre-trained models from large natural image datasets, such as…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Yi Lin , Zhongchen Zhao , Zhengjie ZHU , Lisheng Wang , Kwang-Ting Cheng , Hao Chen

We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

Despite significant advancements, segmentation based on deep neural networks in medical and surgical imaging faces several challenges, two of which we aim to address in this work. First, acquiring complete pixel-level segmentation labels…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Junwen Wang , Zhonghao Wang , Oscar MacCormac , Jonathan Shapey , Tom Vercauteren

Whole-slide image (WSI) classification is a challenging task because 1) patches from WSI lack annotation, and 2) WSI possesses unnecessary variability, e.g., stain protocol. Recently, Multiple-Instance Learning (MIL) has made significant…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Joohyung Lee , Heejeong Nam , Kwanhyung Lee , Sangchul Hahn

Deep convolutional neural networks have driven substantial advancements in the automatic understanding of images. Requiring a large collection of images and their associated annotations is one of the main bottlenecks limiting the adoption…

Computer Vision and Pattern Recognition · Computer Science 2019-08-22 Zahra Mirikharaji , Yiqi Yan , Ghassan Hamarneh

Digital pathology involves converting physical tissue slides into high-resolution Whole Slide Images (WSIs), which pathologists analyze for disease-affected tissues. However, large histology slides with numerous microscopic fields pose…

Image and Video Processing · Electrical Eng. & Systems 2024-02-19 Mobina Mansoori , Sajjad Shahabodini , Jamshid Abouei , Arash Mohammadi , Konstantinos N. Plataniotis

Trained using only image class label, deep weakly supervised methods allow image classification and ROI segmentation for interpretability. Despite their success on natural images, they face several challenges over histology data where ROI…

Image and Video Processing · Electrical Eng. & Systems 2022-05-13 Soufiane Belharbi , Jérôme Rony , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Tissue typology annotation in Whole Slide histological images is a complex and tedious, yet necessary task for the development of computational pathology models. We propose to address this problem by applying Open Set Recognition techniques…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Adrian Galdran , Katherine J. Hewitt , Narmin L. Ghaffari , Jakob N. Kather , Gustavo Carneiro , Miguel A. González Ballester

Deep neural networks have achieved remarkable success in a wide variety of natural image and medical image computing tasks. However, these achievements indispensably rely on accurately annotated training data. If encountering some…

Image and Video Processing · Electrical Eng. & Systems 2022-05-11 Cheng Xue , Lequan Yu , Pengfei Chen , Qi Dou , Pheng-Ann Heng

Subspace clustering is a powerful unsupervised approach for hyperspectral image (HSI) analysis, but its high computational and memory costs limit scalability. Superpixel segmentation can improve efficiency by reducing the number of data…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Xianlu Li , Nicolas Nadisic , Shaoguang Huang , Aleksandra Pizurica

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Training a neural network with a large labeled dataset is still a dominant paradigm in computational histopathology. However, obtaining such exhaustive manual annotations is often expensive, laborious, and prone to inter and Intra-observer…

Computer Vision and Pattern Recognition · Computer Science 2021-11-03 Chetan L. Srinidhi , Seung Wook Kim , Fu-Der Chen , Anne L. Martel

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Addressing the annotation challenge in 3D Point Cloud segmentation has inspired research into weakly supervised learning. Existing approaches mainly focus on exploiting manifold and pseudo-labeling to make use of large unlabeled data…

Computer Vision and Pattern Recognition · Computer Science 2022-05-09 Yongyi Su , Xun Xu , Kui Jia

Current approaches for classification of whole slide images (WSI) in digital pathology predominantly utilize a two-stage learning pipeline. The first stage identifies areas of interest (e.g. tumor tissue), while the second stage processes…

Computer Vision and Pattern Recognition · Computer Science 2022-07-20 Marvin Teichmann , Andre Aichert , Hanibal Bohnenberger , Philipp Ströbel , Tobias Heimann

Analysis of histopathology slides is a critical step for many diagnoses, and in particular in oncology where it defines the gold standard. In the case of digital histopathological analysis, highly trained pathologists must review vast…

Computer Vision and Pattern Recognition · Computer Science 2020-02-21 Pierre Courtiol , Eric W. Tramel , Marc Sanselme , Gilles Wainrib

The cost of large scale data collection and annotation often makes the application of machine learning algorithms to new tasks or datasets prohibitively expensive. One approach circumventing this cost is training models on synthetic data…

Computer Vision and Pattern Recognition · Computer Science 2016-08-23 Konstantinos Bousmalis , George Trigeorgis , Nathan Silberman , Dilip Krishnan , Dumitru Erhan

Deep learning methods have achieved promising performance in many areas, but they are still struggling with noisy-labeled images during the training process. Considering that the annotation quality indispensably relies on great expertise,…

Computer Vision and Pattern Recognition · Computer Science 2019-07-30 Haidong Zhu , Jialin Shi , Ji Wu

Deep-learning pipelines for microscopy image classification often require expensive, labor- and time-intensive expert annotation to produce high-quality ground truth for training. Recent work has shown that prompt tuning of vision-language…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Abhiram Kandiyana , Ankur Mali , Lawrence O. Hall , Peter R. Mouton , Dmitry Goldgof