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Microtechnology becomes a versatile tool for biological and biomedical applications. Microwells have been established long but remained non-intelligent up to now. Merging new fabrication techniques and handling concepts with…

Other Computer Science · Computer Science 2008-02-22 E. Jung , D. Manessis , A. Neumann , L. Bottcher , T. Braun , J. Bauer , H. Reichl , B. Iafelice , F. Destro , R. Gambari

Space filling designs are central to studying complex systems in various areas of science. They are used for obtaining an overall understanding of the behaviour of the response over the input space, model construction and uncertainty…

Methodology · Statistics 2016-08-10 Shirin Golchi , Jason L. Loeppky

In this paper, we revisit the large-scale constrained linear regression problem and propose faster methods based on some recent developments in sketching and optimization. Our algorithms combine (accelerated) mini-batch SGD with a new…

Machine Learning · Computer Science 2018-02-12 Di Wang , Jinhui Xu

We develop a model-based methodology for integrating gene-set information with an experimentally-derived gene list. The methodology uses a previously reported sampling model, but takes advantage of natural constraints in the…

Methodology · Statistics 2015-06-02 Zhishi Wang , Qiuling He , Bret Larget , Michael A. Newton

The saturation-based reasoning methods are among the most theoretically developed ones and are used by most of the state-of-the-art first-order logic reasoners. In the last decade there was a sharp increase in performance of such systems,…

Artificial Intelligence · Computer Science 2008-02-18 Alexandre Riazanov

Superconducting materials find applications in a rapidly growing number of technological areas, and searching for novel superconductors continues to be a major scientific task. However, the steady increase in the complexity of candidate…

Superconductivity · Physics 2019-12-20 J. Yuan , V. Stanev , C. Gao , I. Takeuchi , K. Jin

The current bulk materials discovery cycle has several inefficiencies from initial computational predictions through fabrication and analyses. Materials are generally evaluated in a singular fashion, relying largely on human-driven…

Materials Science · Physics 2021-02-12 Olivia F. Dippo , Kevin R. Kaufmann , Kenneth S. Vecchio

Selection of covariates is crucial in the estimation of average treatment effects given observational data with high or even ultra-high dimensional pretreatment variables. Existing methods for this problem typically assume sparse linear…

Methodology · Statistics 2023-03-20 Juan Chen , Yingchun Zhou

In variable or graph selection problems, finding a right-sized model or controlling the number of false positives is notoriously difficult. Recently, a meta-algorithm called Stability Selection was proposed that can provide reliable…

Machine Learning · Statistics 2017-12-14 George Philipp , Seunghak Lee , Eric P. Xing

The technique presented here identifies tethered mould designs, optimised for growing cultured tissue with very highly-aligned cells. It is based on a microscopic biophysical model for polarised cellular hydrogels. There is an unmet need…

Biological Physics · Physics 2023-06-26 James P. Hague , Allison E. Andrews , Hugh Dickinson

The problems of Lasso regression and optimal design of experiments share a critical property: their optimal solutions are typically \emph{sparse}, i.e., only a small fraction of the optimal variables are non-zero. Therefore, the…

Methodology · Statistics 2023-12-07 Guillaume Sagnol , Luc Pronzato

Space-filling designs are important in computer experiments, which are critical for building a cheap surrogate model that adequately approximates an expensive computer code. Many design construction techniques in the existing literature are…

Methodology · Statistics 2022-08-30 Chaofan Huang , V. Roshan Joseph , Douglas M. Ray

The method of constrained randomisation is applied to three-dimensional simulated galaxy distributions. With this technique we generate for a given data set surrogate data sets which have the same linear properties as the original data…

Astrophysics · Physics 2009-11-07 C. Raeth , W. Bunk , M. Huber , G. Morfill , J. Retzlaff , P. Schuecker

Constraint Programming is a powerful paradigm to model and solve combinatorial problems. While there are many kinds of constraints, the table constraint is perhaps the most significant-being the most well-studied and has the ability to…

Databases · Computer Science 2022-03-23 Soufia Bennai , Kamala Amroun , Samir Loudni , Abdelkader Ouali

The scenario approach is widely used in robust control system design and chance-constrained optimization, maintaining convexity without requiring assumptions about the probability distribution of uncertain parameters. However, the approach…

Optimization and Control · Mathematics 2024-12-10 Jaeseok Choi , Anand Deo , Constantino Lagoa , Anirudh Subramanyam

Progress in automated microscopy and quantitative image analysis has promoted high-content screening (HCS) as an efficient drug discovery and research tool. While HCS offers to quantify complex cellular phenotypes from images at high…

Computer Vision and Pattern Recognition · Computer Science 2022-08-10 Umar Masud , Ethan Cohen , Ihab Bendidi , Guillaume Bollot , Auguste Genovesio

High throughput mRNA expression profiling can be used to characterize the response of cell culture models to perturbations such as pharmacologic modulators and genetic perturbations. As profiling campaigns expand in scope, it is important…

Genomics · Quantitative Biology 2017-04-12 Tracey Filzen , Peter Kutchukian , Jeffrey Hermes , Jing Li , Matthew Tudor

Lines of sight with multiple, projected, cluster-scale halos have high total masses and complex lens plane interactions that can boost the area of magnification, or etendue, making detection of faint background sources more likely than…

Cosmology and Nongalactic Astrophysics · Physics 2015-06-17 S. Mark Ammons , Kenneth C. Wong , Ann I. Zabludoff , Charles R. Keeton

The analysis of high-dimensional data, common in fields such as genomics, is complicated by the presence of cellwise contamination, where individual cells rather than entire rows are corrupted. This contamination poses a significant…

Methodology · Statistics 2026-03-31 Anthony Christidis , Jeyshinee Pyneeandee , Gabriela Cohen-Freue

Recently introduced, spaceplates achieve the propagation of light for a distance greater than their thickness. In this way, they compress optical space, reducing the required distance between optical elements in an imaging system. Here we…

Optics · Physics 2023-06-01 Nicholas J. Sorensen , Michael T. Weil , Jeff S. Lundeen