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The aggressiveness of prostate cancer, the most common cancer in men worldwide, is primarily assessed based on histopathological data using the Gleason scoring system. While artificial intelligence (AI) has shown promise in accurately…

Prostate cancer (PCa) is one of the most common and aggressive cancers worldwide. The Gleason score (GS) system is the standard way of classifying prostate cancer and the most reliable method to determine the severity and treatment to…

Computer Vision and Pattern Recognition · Computer Science 2021-03-05 Santiago Toledo-Cortés , Diego H. Useche , Fabio A. González

Worldwide, prostate cancer is one of the main cancers affecting men. The final diagnosis of prostate cancer is based on the visual detection of Gleason patterns in prostate biopsy by pathologists. Computer-aided-diagnosis systems allow to…

Computer Vision and Pattern Recognition · Computer Science 2020-05-26 Amartya Kalapahar , Julio Silva-Rodríguez , Adrián Colomer , Fernando López-Mir , Valery Naranjo

The Gleason scoring system is the primary diagnostic and prognostic tool for prostate cancer. In recent years, with the development of digitisation devices, the use of computer vision techniques for the analysis of biopsies has increased.…

Image and Video Processing · Electrical Eng. & Systems 2021-05-25 Julio Silva-Rodríguez , Adrián Colomer , María A. Sales , Rafael Molina , Valery Naranjo

The Gleason score is the most important prognostic marker for prostate cancer patients but suffers from significant inter-observer variability. We developed a fully automated deep learning system to grade prostate biopsies. The system was…

Multiparametric magnetic resonance imaging (mp-MRI) has shown excellent results in the detection of prostate cancer (PCa). However, characterizing prostate lesions aggressiveness in mp-MRI sequences is impossible in clinical practice, and…

Image and Video Processing · Electrical Eng. & Systems 2022-11-28 Audrey Duran , Gaspard Dussert , Olivier Rouvière , Tristan Jaouen , Pierre-Marc Jodoin , Carole Lartizien

Prostate cancer is the most common cancer in men worldwide and the second leading cause of cancer death in the United States. One of the prognostic features in prostate cancer is the Gleason grading of histopathology images. The Gleason…

Image and Video Processing · Electrical Eng. & Systems 2022-12-27 Mohammad Mahdi Behzadi , Mohammad Madani , Hanzhang Wang , Jun Bai , Ankit Bhardwaj , Anna Tarakanova , Harold Yamase , Ga Hie Nam , Sheida Nabavi

Prostate cancer is one of the main diseases affecting men worldwide. The gold standard for diagnosis and prognosis is the Gleason grading system. In this process, pathologists manually analyze prostate histology slides under microscope, in…

Image and Video Processing · Electrical Eng. & Systems 2021-05-24 Julio Silva-Rodríguez , Adrián Colomer , Jose Dolz , Valery Naranjo

High dimensional Poisson regression has become a standard framework for the analysis of massive counts datasets. In this work we estimate the intensity function of the Poisson regression model by using a dictionary approach, which…

Methodology · Statistics 2014-12-30 S. Ivanoff , F. Picard , V. Rivoirard

Prostate cancer (PCa) is one of the most common cancers in men around the world. The most accurate method to evaluate lesion levels of PCa is microscopic inspection of stained biopsy tissue and estimate the Gleason score of tissue…

Image and Video Processing · Electrical Eng. & Systems 2020-05-12 Yi-hong Zhang , Jing Zhang , Yang Song , Chaomin Shen , Guang Yang

For prostate cancer patients, the Gleason score is one of the most important prognostic factors, potentially determining treatment independent of the stage. However, Gleason scoring is based on subjective microscopic examination of tumor…

Prostate cancer is the second most common form of cancer, though most patients have a positive prognosis with many experiencing long-term survival with current treatment options. Yet, each treatment carries varying levels of intensity and…

Quantitative Methods · Quantitative Biology 2024-10-31 Jefferson Zhou , Kahn Rhrissorrakrai

Histology-based grade classification is clinically important for many cancer types in stratifying patients distinct treatment groups. In prostate cancer, the Gleason score is a grading system used to measure the aggressiveness of prostate…

Computer Vision and Pattern Recognition · Computer Science 2019-11-07 Jingwen Wang , Richard J. Chen , Ming Y. Lu , Alexander Baras , Faisal Mahmood

Modeling count data is important in physics and other scientific disciplines, where measurements often involve discrete, non-negative quantities such as photon or neutrino detection events. Traditional parametric approaches can be trained…

Data Analysis, Statistics and Probability · Physics 2026-02-10 Anushka Saha , Abhijith Gandrakota , Alexandre V. Morozov

The Gleason grading system using histological images is the most powerful diagnostic and prognostic predictor of prostate cancer. The current standard inspection is evaluating Gleason H&E-stained histopathology images by pathologists.…

Image and Video Processing · Electrical Eng. & Systems 2020-12-10 Haotian Xie , Yong Zhang , Jun Wang , Jingjing Zhang , Yifan Ma , Zhaogang Yang

Gleason grading of prostate cancer is an important prognostic factor but suffers from poor reproducibility, particularly among non-subspecialist pathologists. Although artificial intelligence (A.I.) tools have demonstrated Gleason grading…

Pathologists diagnose and grade prostate cancer by examining tissue from needle biopsies on glass slides. The cancer's severity and risk of metastasis are determined by the Gleason grade, a score based on the organization and morphology of…

Image and Video Processing · Electrical Eng. & Systems 2022-09-28 Alessandro Ferrero , Beatrice Knudsen , Deepika Sirohi , Ross Whitaker

Alzheimer's disease is a major cause of dementia. Its diagnosis requires accurate biomarkers that are sensitive to disease stages. In this respect, we regard probabilistic classification as a method of designing a probabilistic biomarker…

Machine Learning · Computer Science 2017-06-06 Murat Seckin Ayhan , Vijay Raghavan , Alzheimer's disease Neuroimaging Initiative

Prostate cancer is one of the main diseases affecting men worldwide. The Gleason scoring system is the primary diagnostic tool for prostate cancer. This is obtained via the visual analysis of cancerous patterns in prostate biopsies…

Image and Video Processing · Electrical Eng. & Systems 2021-05-24 Julio Silva-Rodríguez , Adrián Colomer , Valery Naranjo

Prostate cancer ranks among the leading health issues impacting men, with the Gleason scoring system serving as the primary method for diagnosis and prognosis. This system relies on expert pathologists to evaluate samples of prostate tissue…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Amin Malekmohammadi , Ali Badiezadeh , Seyed Mostafa Mirhassani , Parisa Gifani , Majid Vafaeezadeh
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