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Although RNA-Seq data provide unprecedented isoform-level expression information, detection of alternative isoform regulation (AIR) remains difficult, particularly when working with an incomplete transcript annotation. We introduce…

Genomics · Quantitative Biology 2016-06-03 Stephen W. Hartley , James C. Mullikin

Although atomistic simulations of proteins and other biological systems are approaching microsecond timescales, the quality of trajectories has remained difficult to assess. Such assessment is critical not only for establishing the…

Quantitative Methods · Quantitative Biology 2007-05-23 Edward Lyman , Daniel M. Zuckerman

For scientific machine learning tasks with a lot of custom code, picking the right Automatic Differentiation (AD) system matters. Our Julia package DifferentiationInterface$.$jl provides a common frontend to a dozen AD backends, unlocking…

Mathematical Software · Computer Science 2025-05-19 Guillaume Dalle , Adrian Hill

Accurate air quality prediction is essential for public health, environmental monitoring, and industrial safety. However, most existing approaches rely on centralized learning paradigms, which introduce challenges related to scalability,…

Machine Learning · Computer Science 2026-05-19 Manjil Nepal , Kimsie Phan , Tamoghna Ojha , Aritra Dutta , M Krishna Siva Prasad

We present first results on the calculation of fermionic spectral functions from analytically continued flow equations within the Functional Renormalization Group approach. Our method is based on the same analytic continuation from…

High Energy Physics - Phenomenology · Physics 2018-11-14 Ralf-Arno Tripolt , Johannes Weyrich , Lorenz von Smekal , Jochen Wambach

Canonical Correlation Analysis, CCA, is a widely used multivariate method in omics research for integrating high dimensional datasets. CCA identifies hidden links by deriving linear projections of features maximally correlating datasets.…

Methodology · Statistics 2025-10-31 Nuria Senar , Aeilko H. Zwinderman , Michel H. Hof and

OutlierDetection.jl is an open-source ecosystem for outlier detection in Julia. It provides a range of high-performance outlier detection algorithms implemented directly in Julia. In contrast to previous packages, our ecosystem enables the…

Machine Learning · Computer Science 2022-11-10 David Muhr , Michael Affenzeller , Anthony D. Blaom

Schemes of classical shadows have been developed to facilitate the read-out of digital quantum devices, but similar tools for analog quantum simulators are scarce and experimentally impractical. In this work, we provide a measurement scheme…

Quantum Physics · Physics 2024-12-18 Janek Denzler , Antonio Anna Mele , Ellen Derbyshire , Tommaso Guaita , Jens Eisert

Autoregressive decoding makes the inference of Large Language Models (LLMs) time-consuming. In this paper, we reconsider speculative sampling and derive two key observations. Firstly, autoregression at the feature (second-to-top-layer)…

Machine Learning · Computer Science 2025-03-05 Yuhui Li , Fangyun Wei , Chao Zhang , Hongyang Zhang

FAYE, The Frame AnalYsis Executable, is a Java based implementation of the Frame/Stream/Stop model for analyzing data. Unlike traditional Event based analysis models, the Frame/Stream/Stop model has no preference as to which part of any…

Software Engineering · Computer Science 2007-05-23 S. Patton

The Parareal algorithm allows to solve evolution problems exploiting parallelization in time. Its convergence and stability have been proved under the assumption of regular (smooth) inputs. We present and analyze here a new Parareal…

Numerical Analysis · Mathematics 2019-04-09 Martin J. Gander , Iryna Kulchytska-Ruchka , Innocent Niyonzima , Sebastian Schöps

We consider a sparse grid collocation method in conjunction with a time discretization of the differential equations for computing expectations of functionals of solutions to differential equations perturbed by time-dependent white noise.…

Numerical Analysis · Mathematics 2015-05-18 Z. Zhang , M. V. Tretyakov , B. Rozovskii , G. E. Karniadakis

SymBoltz is a new Julia package for solving the linear Einstein-Boltzmann equations in cosmology. It features a symbolic-numeric interface for specifying equations, is free of approximation switching schemes, and is compatible with…

Cosmology and Nongalactic Astrophysics · Physics 2026-03-11 Herman Sletmoen

This paper proposes a modeling framework for dynamic topic evolution based on temporal large language models. The method first uses a large language model to obtain contextual embeddings of text and then introduces a temporal decay function…

Computation and Language · Computer Science 2025-11-04 Di Wu , Shuaidong Pan

SymJAX is a symbolic programming version of JAX simplifying graph input/output/updates and providing additional functionalities for general machine learning and deep learning applications. From an user perspective SymJAX provides a la…

Mathematical Software · Computer Science 2020-05-22 Randall Balestriero

Working towards the development of an evolvable cancer treatment simulator, the investigation of Differential Evolution was considered, motivated by the high efficiency of variations of this technique in real-valued problems. A basic DE…

Neural and Evolutionary Computing · Computer Science 2020-03-27 Michail-Antisthenis Tsompanas , Larry Bull , Andrew Adamatzky , Igor Balaz

We introduce the multi-dimensional Skellam mechanism, a discrete differential privacy mechanism based on the difference of two independent Poisson random variables. To quantify its privacy guarantees, we analyze the privacy loss…

Machine Learning · Computer Science 2021-11-01 Naman Agarwal , Peter Kairouz , Ziyu Liu

Score-based modeling through stochastic differential equations (SDEs) has provided a new perspective on diffusion models, and demonstrated superior performance on continuous data. However, the gradient of the log-likelihood function, i.e.,…

Machine Learning · Computer Science 2023-03-07 Haoran Sun , Lijun Yu , Bo Dai , Dale Schuurmans , Hanjun Dai

MicroMagnetic.jl is an open-source Julia package for micromagnetic and atomistic simulations. Using the features of the Julia programming language, MicroMagnetic.jl supports CPU and various GPU platforms, including NVIDIA, AMD, Intel, and…

Mesoscale and Nanoscale Physics · Physics 2024-09-09 Weiwei Wang , Boyao Lyu , Lingyao Kong , Hans Fangohr , Haifeng Du

Maintaining a dynamic $k$-core decomposition is an important problem that identifies dense subgraphs in dynamically changing graphs. Recent work by Liu et al. [SPAA 2022] presents a parallel batch-dynamic algorithm for maintaining an…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-01-17 Quanquan C. Liu , Julian Shun , Igor Zablotchi