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Safe deployment of machine learning (ML) models in safety-critical domains such as medical imaging requires detecting inputs with characteristics not seen during training, known as out-of-distribution (OOD) detection, to prevent unreliable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-05 Felix Wagner , Pramit Saha , Harry Anthony , J. Alison Noble , Konstantinos Kamnitsas

Standard recognition approaches are unable to deal with novel categories at test time. Their overconfidence on the known classes makes the predictions unreliable for safety-critical applications such as healthcare or autonomous driving.…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Lorenzo Li Lu , Giulia D'Ascenzi , Francesco Cappio Borlino , Tatiana Tommasi

Detecting out-of-distribution (OOD) data is a critical challenge in machine learning due to model overconfidence, often without awareness of their epistemological limits. We hypothesize that ``neural collapse'', a phenomenon affecting…

Machine Learning · Statistics 2024-02-28 Mouïn Ben Ammar , Nacim Belkhir , Sebastian Popescu , Antoine Manzanera , Gianni Franchi

Recent advances in deep learning have led to breakthroughs in the development of automated skin disease classification. As we observe an increasing interest in these models in the dermatology space, it is crucial to address aspects such as…

Computer Vision and Pattern Recognition · Computer Science 2021-06-03 Hannah Kim , Girmaw Abebe Tadesse , Celia Cintas , Skyler Speakman , Kush Varshney

Machine learning-assisted retrosynthesis prediction models have been gaining widespread adoption, though their performances oftentimes degrade significantly when deployed in real-world applications embracing out-of-distribution (OOD)…

Machine Learning · Computer Science 2023-12-19 Yemin Yu , Luotian Yuan , Ying Wei , Hanyu Gao , Xinhai Ye , Zhihua Wang , Fei Wu

Neural networks (NNs) are widely used for object classification in autonomous driving. However, NNs can fail on input data not well represented by the training dataset, known as out-of-distribution (OOD) data. A mechanism to detect OOD…

Computer Vision and Pattern Recognition · Computer Science 2021-09-07 Julia Nitsch , Masha Itkina , Ransalu Senanayake , Juan Nieto , Max Schmidt , Roland Siegwart , Mykel J. Kochenderfer , Cesar Cadena

Unsupervised out-of-distribution detection (OOD) seeks to identify out-of-domain data by learning only from unlabeled in-domain data. We present a novel approach for this task - Lift, Map, Detect (LMD) - that leverages recent advancement in…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Zhenzhen Liu , Jin Peng Zhou , Yufan Wang , Kilian Q. Weinberger

Background: Machine learning (ML) methods often fail with data that deviates from their training distribution. This is a significant concern for ML-enabled devices in clinical settings, where data drift may cause unexpected performance that…

Artificial Intelligence · Computer Science 2024-02-14 Ghada Zamzmi , Kesavan Venkatesh , Brandon Nelson , Smriti Prathapan , Paul H. Yi , Berkman Sahiner , Jana G. Delfino

Deep Learning models perform unreliably when the data comes from a distribution different from the training one. In critical applications such as medical imaging, out-of-distribution (OOD) detection methods help to identify such data…

Image and Video Processing · Electrical Eng. & Systems 2023-06-26 Anton Vasiliuk , Daria Frolova , Mikhail Belyaev , Boris Shirokikh

Machine Learning (ML) techniques have found applications in estimating chemical kinetic properties. With the accumulated drug molecules identified through "AI4drug discovery", the next imperative lies in AI-driven design for high-throughput…

Machine Learning · Computer Science 2023-12-06 Zihao Wang , Yongqiang Chen , Yang Duan , Weijiang Li , Bo Han , James Cheng , Hanghang Tong

Machine Learning (ML) models are trained on in-distribution (ID) data but often encounter out-of-distribution (OOD) inputs during deployment -- posing serious risks in safety-critical domains. Recent works have focused on designing scoring…

Machine Learning · Computer Science 2025-05-06 Daisuke Yamada , Harit Vishwakarma , Ramya Korlakai Vinayak

Out-of-distribution (OOD) detection is crucial for ensuring reliable deployment of machine learning models. Recent advancements focus on utilizing easily accessible auxiliary outliers (e.g., data from the web or other datasets) in training.…

Machine Learning · Computer Science 2024-11-22 Haiyun Yao , Zongbo Han , Huazhu Fu , Xi Peng , Qinghua Hu , Changqing Zhang

Deep learned (DL) models for image recognition have been shown to fail to generalize to data from different devices, populations, etc. COVID-19 detection from Chest X-rays (CXRs), in particular, has been shown to fail to generalize to…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Duong Mai , Lawrence Hall

Deep neural networks (DNNs) have become the de facto learning mechanism in different domains. Their tendency to perform unreliably on out-of-distribution (OOD) inputs hinders their adoption in critical domains. Several approaches have been…

Machine Learning · Computer Science 2020-06-26 Vahdat Abdelzad , Krzysztof Czarnecki , Rick Salay

Data outside the problem domain poses significant threats to the security of AI-based intelligent systems. Aiming to investigate the data domain and out-of-distribution (OOD) data in AI quality management (AIQM) study, this paper proposes…

Artificial Intelligence · Computer Science 2023-10-13 Tinghui Ouyang , Isao Echizen , Yoshiki Seo

Many real-world scenarios in which DNN-based recognition systems are deployed have inherently fine-grained attributes (e.g., bird-species recognition, medical image classification). In addition to achieving reliable accuracy, a critical…

Machine Learning · Computer Science 2022-10-21 Jingyang Zhang , Nathan Inkawhich , Randolph Linderman , Yiran Chen , Hai Li

Outlier exposure (OE) is powerful in out-of-distribution (OOD) detection, enhancing detection capability via model fine-tuning with surrogate OOD data. However, surrogate data typically deviate from test OOD data. Thus, the performance of…

Machine Learning · Computer Science 2023-03-10 Qizhou Wang , Junjie Ye , Feng Liu , Quanyu Dai , Marcus Kalander , Tongliang Liu , Jianye Hao , Bo Han

Deep neural networks often face generalization problems to handle out-of-distribution (OOD) data, and there remains a notable theoretical gap between the contributing factors and their respective impacts. Literature evidence from…

Machine Learning · Computer Science 2024-04-24 Songming Zhang , Yuxiao Luo , Qizhou Wang , Haoang Chi , Xiaofeng Chen , Bo Han , Jinyan Li

Deep neural networks have attained remarkable performance when applied to data that comes from the same distribution as that of the training set, but can significantly degrade otherwise. Therefore, detecting whether an example is…

Computer Vision and Pattern Recognition · Computer Science 2020-04-02 Yen-Chang Hsu , Yilin Shen , Hongxia Jin , Zsolt Kira

Deep neural networks are known to achieve superior results in classification tasks. However, it has been recently shown that they are incapable to detect examples that are generated by a distribution which is different than the one they…

Machine Learning · Computer Science 2019-12-09 Aristotelis-Angelos Papadopoulos , Nazim Shaikh , Mohammad Reza Rajati