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Non-rigid registration is a necessary but challenging task in medical imaging studies. Recently, unsupervised registration models have shown good performance, but they often require a large-scale training dataset and long training times.…

Computer Vision and Pattern Recognition · Computer Science 2021-04-22 Heejung Park , Gyeong Min Lee , Soopil Kim , Ga Hyung Ryu , Areum Jeong , Sang Hyun Park , Min Sagong

This paper presents a new regularization method to train a fully convolutional network for semantic tissue segmentation in histopathological images. This method relies on the benefit of unsupervised learning, in the form of image…

Computer Vision and Pattern Recognition · Computer Science 2020-11-26 C. T. Sari , C. Sokmensuer , C. Gunduz-Demir

This paper presents a predictive model for estimating regularization parameters of diffeomorphic image registration. We introduce a novel framework that automatically determines the parameters controlling the smoothness of diffeomorphic…

Image and Video Processing · Electrical Eng. & Systems 2022-02-08 Jian Wang , Miaomiao Zhang

The aim of this paper is to establish a nonlinear variational approach to the reconstruction of moving density images from indirect dynamic measurements. Our approach is to model the dynamics as a hyperelastic deformation of an initial…

Numerical Analysis · Mathematics 2015-12-01 Martin Burger , Jan Modersitzki , Sebastian Suhr

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

In this paper, we propose three novel and important methods for the registration of histological images for 3D reconstruction. First, possible intensity variations and nonstandardness in images are corrected by an intensity standardization…

Computer Vision and Pattern Recognition · Computer Science 2009-07-21 Ulas Bagci , Li Bai

Data augmentation has proved extremely useful by increasing training data variance to alleviate overfitting and improve deep neural networks' generalization performance. In medical image analysis, a well-designed augmentation policy usually…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Yunhe Gao , Zhiqiang Tang , Mu Zhou , Dimitris Metaxas

In this paper, we introduce a physics-driven regularization method for training of deep neural networks (DNNs) for use in engineering design and analysis problems. In particular, we focus on prediction of a physical system, for which in…

Machine Learning · Computer Science 2019-10-17 Mohammad Amin Nabian , Hadi Meidani

3-D image registration, which involves aligning two or more images, is a critical step in a variety of medical applications from diagnosis to therapy. Image registration is commonly performed by optimizing an image matching metric as a cost…

Computer Vision and Pattern Recognition · Computer Science 2016-12-01 Rui Liao , Shun Miao , Pierre de Tournemire , Sasa Grbic , Ali Kamen , Tommaso Mansi , Dorin Comaniciu

Despite recent advances in regularisation theory, the issue of parameter selection still remains a challenge for most applications. In a recent work the framework of statistical learning was used to approximate the optimal Tikhonov…

Machine Learning · Statistics 2019-05-30 Ernesto de Vito , Zeljko Kereta , Valeria Naumova

Deformable image registration is a fundamental problem in the field of medical image analysis. During the last years, we have witnessed the advent of deep learning-based image registration methods which achieve state-of-the-art performance,…

Image and Video Processing · Electrical Eng. & Systems 2020-02-03 Lucas Mansilla , Diego H. Milone , Enzo Ferrante

High-dimensional, streaming datasets are ubiquitous in modern applications. Examples range from finance and e-commerce to the study of biomedical and neuroimaging data. As a result, many novel algorithms have been proposed to address…

Methodology · Statistics 2020-09-28 Lenka Zboňáková , Ricardo Pio Monti , Wolfgang Karl Härdle

We propose a physics-based regularization technique for function learning, inspired by statistical mechanics. By drawing an analogy between optimizing the parameters of an interpolator and minimizing the energy of a system, we introduce…

Machine Learning · Computer Science 2025-08-20 Abhisek Ganguly , Alessandro Gabbana , Vybhav Rao , Sauro Succi , Santosh Ansumali

The reconstruction of images from their corresponding noisy Radon transform is a typical example of an ill-posed linear inverse problem as arising in the application of computerized tomography (CT). As the (naive) solution does not depend…

Selecting the best regularization parameter in inverse problems is a classical and yet challenging problem. Recently, data-driven approaches have become popular to tackle this challenge. These approaches are appealing since they do require…

Statistics Theory · Mathematics 2025-10-22 Jonathan Chirinos Rodriguez , Ernesto De Vito , Cesare Molinari , Lorenzo Rosasco , Silvia Villa

Hybrid volumetric medical image segmentation models, combining the advantages of local convolution and global attention, have recently received considerable attention. While mainly focusing on architectural modifications, most existing…

Image and Video Processing · Electrical Eng. & Systems 2024-04-04 Shahina Kunhimon , Abdelrahman Shaker , Muzammal Naseer , Salman Khan , Fahad Shahbaz Khan

Machine learning models often require large datasets and struggle to generalize beyond their training distribution. These limitations pose significant challenges in scientific and engineering contexts, where generating exhaustive datasets…

Chemical Physics · Physics 2025-06-12 Salman N. Salman , Sergey A. Shteingolts , Ron Levie , Dan Mendels

High-fidelity biomechanical models usually involve the mechanical characterization of biological tissues using experimental methods based on optical measurements. In most experiments, strains are evaluated based on displacements of a few…

Image and Video Processing · Electrical Eng. & Systems 2023-01-10 Ondřej Lisický , Stéphane Avril , Bastien Eydan , Baptiste Pierrat , Jiří Burša

Multimodal image registration is a challenging but essential step for numerous image-guided procedures. Most registration algorithms rely on the computation of complex, frequently non-differentiable similarity metrics to deal with the…

Computer Vision and Pattern Recognition · Computer Science 2023-07-20 Matteo Ronchetti , Wolfgang Wein , Nassir Navab , Oliver Zettinig , Raphael Prevost

When adopting a model-based formulation, solving inverse problems encountered in multiband imaging requires to define spatial and spectral regularizations. In most of the works of the literature, spectral information is extracted from the…

Image and Video Processing · Electrical Eng. & Systems 2023-07-03 Min Zhao , Nicolas Dobigeon , Jie Chen