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Understanding interactions between microparticles and lipid membranes is of increasing importance, especially for unraveling the influence of microplastics on our health and environment. Here, we study how a short-ranged adhesive force…

Soft Condensed Matter · Physics 2017-10-11 Casper van der Wel , Doris Heinrich , Daniela J. Kraft

Integral membrane proteins deform the surrounding bilayer creating long-ranged forces that influence distant proteins. These forces can be attractive or repulsive, depending on the proteins' shape, height, contact angle with the bilayer, as…

Statistical Mechanics · Physics 2007-05-23 Tom Chou , Ken S. Kim , George Oster

The surface curvature of membranes, interfaces, and substrates plays a crucial role in shaping the self-assembly of particles adsorbed on these surfaces. However, little is known about the interplay between particle anisotropy and surface…

Soft Condensed Matter · Physics 2025-10-30 Gautam Bordia , Thomas P. Russell , Ahmad K. Omar

Due to the potential applications in biomedical engineering, it becomes more and more important to understand the process of engulfment and internalization of nanoparticles (NPs) by cell membranes. Despite the fact that the interaction…

Biological Physics · Physics 2023-12-12 Ke Xiao , Jing Li , Rui Ma , Chen-Xu Wu

Membrane-induced interactions have been predicted to be important for the organization of membrane proteins. Measurements of the interactions between two and three membrane deforming objects have revealed their non-additive nature. They are…

Soft Condensed Matter · Physics 2024-03-11 Ali Azadbakht , Thomas R. Weikl , Daniela J. Kraft

A variety of models for the membrane-mediated interaction of particles in lipid membranes, mostly well-established in theoretical physics, is reviewed from a mathematical perspective. We provide mathematically consistent formulations in a…

Analysis of PDEs · Mathematics 2016-06-29 Charles M. Elliott , Carsten Gräser , Graham Hobbs , Ralf Kornhuber , Maren-Wanda Wolf

Biological and biomimetic membranes often contain aggregates of embedded or adsorbed macromolecules. In this article, the indirect interactions of cylindrical objects adhering to a planar membrane are considered theoretically. The adhesion…

Soft Condensed Matter · Physics 2009-11-10 Thomas R. Weikl

Membrane wrapping underlies nanoparticle uptake during endocytosis, whereas the reverse process of membrane unwrapping accompanies particle expulsion and membrane fusion events. Existing theoretical descriptions typically focus on adhesion…

Biological Physics · Physics 2026-04-16 Yasin Ranjbar , Yujun Teng , Haleh Alimohammadi , Huajian Gao , Mattia Bacca

Cellular internalization of nanoparticles requires the full wrapping of the nanoparticles by the cell membrane. This wrapping process can occur spontaneously if the adhesive interactions between the nanoparticles and the membranes are…

Subcellular Processes · Quantitative Biology 2015-11-20 Amir Houshang Bahrami , Reinhard Lipowsky , Thomas R. Weikl

Phase-separated biomolecular condensates with liquid-like properties play a key role in the organization and compartmentalization of the intracellular environment. Condensate-mediated capillary forces acting on membranes drive…

A continuum electromechanical model is proposed to describe the membrane curvature induced by electrostatic interactions in a solvated protein-membrane system. The model couples the macroscopic strain energy of membrane and the…

Quantitative Methods · Quantitative Biology 2015-05-19 Y. C. Zhou , Benzhuo Lu , Alemayehu A. Gorfe

Motivated by recent experiments on biomimetic membranes exposed to several aqueous phases, we theoretically study the morphology of a membrane in contact with a liquid droplet formed via aqueous phase separation. We concentrate on membranes…

Soft Condensed Matter · Physics 2012-02-07 Halim Kusumaatmaja , Reinhard Lipowsky

We show that curvatures in general ambient flow profiles can align shape-asymmetric active particles, revealing a previously overlooked competition with externally applied aligning fields. Focusing on the ubiquitous case of channel flows,…

Soft Condensed Matter · Physics 2025-12-16 Derek C. Gomes , Tapan C. Adhyapak

Eukaryote cells have a flexible shape, which dynamically changes according to the function performed by the cell. One mechanism for deforming the cell membrane into the desired shape is through the expression of curved membrane proteins.…

Biological Physics · Physics 2018-12-05 Miha Fošnarič , Samo Penič , Aleš Iglič , Veronika Kralj-Iglič , Mitja Drab , Nir Gov

We explore the interplay of membrane curvature and nonspecific binding due to excluded-volume effects among colloidal particles inside lipid bilayer vesicles. We trapped submicron spheres of two different sizes inside a pear-shaped,…

Soft Condensed Matter · Physics 2009-10-30 A. D. Dinsmore , D. T. Wong , Philip Nelson , A. G. Yodh

A particle placed in soft matter distorts its host and creates an energy landscape. This can occur, for example, for particles in liquid crystals, for particles on lipid bilayers or for particles trapped at fluid interfaces. Such energies…

Soft Condensed Matter · Physics 2015-10-20 Nima Sharifi-Mood , Iris B. Liu , Kathleen J. Stebe

Spatial organisation is a hallmark of all living cells, and recreating it in model systems is a necessary step in the creation of synthetic cells. It is therefore of both fundamental and practical interest to better understand the basic…

Biological Physics · Physics 2017-12-19 Jaime Agudo-Canalejo , Ramin Golestanian

Curvature in biological membranes can be generated by a variety of different molecular mechanisms such as protein scaffolding, lipid or protein asymmetry, cytoskeletal forces, etc. These mechanisms have the net effect of generating stresses…

Membrane budding and wrapping of particles, such as viruses and nano-particles, play a key role in intracellular transport and have been studied for a variety of biological and soft matter systems. We study nano-particle wrapping by…

Soft Condensed Matter · Physics 2013-07-25 Sabyasachi Dasgupta , Thorsten Auth , Gerhard Gompper

We review the theoretical analyses and simulations of the interactions between curvature-inducing proteins and biomembranes. Laterally isotropic proteins induce spherical budding, whereas anisotropic proteins, such as Bin/Amphiphysin/Rvs…

Soft Condensed Matter · Physics 2023-03-10 Hiroshi Noguchi