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Accurate simulations of molecules require high-level electronic-structure theory in combination with rigorous methods for approximating the quantum dynamics. Machine-learning approaches can significantly reduce the computational expense of…

Chemical Physics · Physics 2026-02-24 Valerii Andreichev , Jindra Dušek , Markus Meuwly , Jeremy O. Richardson

Proton-coupled electron transfer (PCET) is the key step for energy conversion in electrocatalysis. Atomic-scale simulation acts as an indispensable tool to provide a microscopic understanding of PCET. However, consideration of the quantum…

Materials Science · Physics 2024-08-27 Menglin Sun , Bin Jin , Xiaolong Yang , Shenzhen Xu

In order to improve the accuracy of molecular dynamics simulations, classical force fields are supplemented with a kernel-based machine learning method trained on quantum-mechanical fragment energies. As an example application, a…

Chemical Physics · Physics 2022-09-12 Joshua T. Berryman , Amirhossein Taghavi , Florian Mazur , Alexandre Tkatchenko

A longstanding computational challenge is the accurate simulation of many-body particle systems. Especially for deriving key characteristics of high-impact but complex systems such as battery materials and high entropy alloys (HEA). While…

Quantum Physics · Physics 2025-11-20 Koen Mesman , Yinglu Tang , Matthias Moller , Boyang Chen , Sebastian Feld

Finding accurate ground state energy of a many-body system has been a major challenge in quantum chemistry. The integration of classic and quantum computers has shed new light on resolving this outstanding problem. Here we propose…

The accurate incorporation of nuclear quantum effects in large-scale molecular dynamics (MD) simulations remains a significant challenge. Recently, we combined constrained nuclear-electronic orbital (CNEO) theory with classical MD and…

Chemical Physics · Physics 2023-01-11 Zehua Chen , Yang Yang

Quantum chemistry applications on quantum computers currently rely heavily on the variational quantum eigensolver (VQE) algorithm. This hybrid quantum-classical algorithm aims at finding ground state solutions of molecular systems based on…

Although electrostatics can be incorporated into machine-learned interatomic potentials, existing approaches are computationally very demanding, limiting large-scale, long-time simulations of electrostatics-driven phenomena such as…

Machine learning techniques are essential tools to compute efficient, yet accurate, force fields for atomistic simulations. This approach has recently been extended to incorporate quantum computational methods, making use of variational…

We present a novel approach to modeling the ground state mass of atomic nuclei based directly on a probabilistic neural network constrained by relevant physics. Our Physically Interpretable Machine Learning (PIML) approach incorporates…

Nuclear Theory · Physics 2022-08-17 M. R. Mumpower , T. M. Sprouse , A. E. Lovell , A. T. Mohan

Quantum machine learning algorithms are expected to play a pivotal role in quantum chemistry simulations in the immediate future. One such key application is the training of a quantum neural network to learn the potential energy surface and…

Quantum Physics · Physics 2024-09-04 Gabriele Lo Monaco , Marco Bertini , Salvatore Lorenzo , G. Massimo Palma

Quantum machine learning (QML) has emerged as an innovative framework with the potential to uncover complex patterns by leveraging quantum systems ability to simulate and exploit high-dimensional latent spaces, particularly in learning…

Quantum Physics · Physics 2025-04-08 Ziqing Guo , Alex Khan , Victor S. Sheng , Shabnam Jabeen , Ziwen Pan

The recently developed Projective Quantum Eigensolver (PQE) has been demonstrated as an elegant methodology to compute the ground state energy of molecular systems in Noisy Intermdiate Scale Quantum (NISQ) devices. The iterative…

Quantum Physics · Physics 2023-03-21 Sonaldeep Halder , Chayan Patra , Dibyendu Mondal , Rahul Maitra

For nearly the past 30 years, Centroid Molecular Dynamics (CMD) has proven to be a viable classical-like phase space formulation for the calculation of quantum dynamical properties. However, calculation of the centroid effective force…

Chemical Physics · Physics 2022-09-15 Timothy D. Loose , Patrick G. Sahrmann , Gregory A. Voth

Attempts to apply Neural Networks (NN) to a wide range of research problems have been ubiquitous and plentiful in recent literature. Particularly, the use of deep NNs for understanding complex physical and chemical phenomena has opened a…

Machine Learning · Computer Science 2021-12-01 Arijit Sehanobish , Hector H. Corzo , Onur Kara , David van Dijk

We investigate the effect of nuclear quantum effects (NQEs) of hydrogen atoms on the elasticity of ice VII at high pressure and ambient temperature conditions using ab initio path-integral molecular dynamics (PIMD) calculations. We find…

Materials Science · Physics 2024-07-09 Jun Tsuchiya , Motoyuki Shiga , Shinji Tsuneyuki , Elizabeth C. Thompson

The spectral features of water clusters provide important information on their structure and dynamics and can assist in deciphering the nature of the local environment of aqueous solutions in a variety of different conditions. Accurately…

Computational Physics · Physics 2026-03-11 T. Baird , R. Vuilleumier , S. Bonella

Machine learning potentials have emerged as a means to enhance the accuracy of biomolecular simulations. However, their application is constrained by the significant computational cost arising from the vast number of parameters compared to…

Modeling nuclear quantum effects is required for accurate molecular dynamics (MD) simulations of molecules. The community has paid special attention to water and other biomolecules that show hydrogen bonding. Standard methods of modeling…

Chemical Physics · Physics 2020-07-06 Vikram Sundar , David Gelbwaser-Klimovsky , Alan Aspuru-Guzik

The atomic-scale response of inhomogeneous fluids at interfaces and surrounding solute particles plays a critical role in governing chemical, electrochemical and biological processes at such interfaces. Classical molecular dynamics…

Materials Science · Physics 2023-11-28 Kamron Fazel , Nima Karimitari , Tanooj Shah , Christopher Sutton , Ravishankar Sundararaman