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In recent years, training methods centered on Reinforcement Learning (RL) have markedly enhanced the reasoning and alignment performance of Large Language Models (LLMs), particularly in understanding human intents, following user…

Computation and Language · Computer Science 2025-09-23 Keliang Liu , Dingkang Yang , Ziyun Qian , Weijie Yin , Yuchi Wang , Hongsheng Li , Jun Liu , Peng Zhai , Yang Liu , Lihua Zhang

Reinforcement learning (RL) has emerged as a powerful method for improving the reasoning abilities of large language models (LLMs). Outcome-based RL, which rewards policies solely for the correctness of the final answer, yields substantial…

Machine Learning · Computer Science 2025-09-09 Yuda Song , Julia Kempe , Remi Munos

Recent developments in Natural Language Processing (NLP) demonstrate that large-scale, self-supervised pre-training can be extremely beneficial for downstream tasks. These ideas have been adapted to other domains, including the analysis of…

Computation and Language · Computer Science 2021-02-02 Matthew B. A. McDermott , Brendan Yap , Harry Hsu , Di Jin , Peter Szolovits

Reinforcement learning (RL) has become a central paradigm for post-training large language models (LLMs), particularly for complex reasoning tasks, yet it often suffers from exploration collapse: policies prematurely concentrate on a small…

Machine Learning · Computer Science 2026-01-16 Zhiyuan Hu , Yucheng Wang , Yufei He , Jiaying Wu , Yilun Zhao , See-Kiong Ng , Cynthia Breazeal , Anh Tuan Luu , Hae Won Park , Bryan Hooi

Recent advancements in improving the reasoning capabilities of Large Language Models have underscored the efficacy of Process Reward Models (PRMs) in addressing intermediate errors through structured feedback mechanisms. This study analyzes…

Computation and Language · Computer Science 2025-06-03 Zhengyu Chen , Yudong Wang , Teng Xiao , Ruochen Zhou , Xuesheng Yang , Wei Wang , Zhifang Sui , Jingang Wang

Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the…

Biomolecules · Quantitative Biology 2019-04-23 Kevin K. Yang , Zachary Wu , Frances H. Arnold

We introduce a large language model (LLM) capable of processing speech inputs and show that tuning it further with reinforcement learning on human preference (RLHF) enables it to adapt better to disordered speech than traditional…

Audio and Speech Processing · Electrical Eng. & Systems 2025-01-03 Chirag Nagpal , Subhashini Venugopalan , Jimmy Tobin , Marilyn Ladewig , Katherine Heller , Katrin Tomanek

Reinforcement learning (RL) is a promising approach for aligning large language models (LLMs) knowledge with sequential decision-making tasks. However, few studies have thoroughly investigated the impact on LLM agents capabilities of…

Process rewards have been widely used in deep reinforcement learning to improve training efficiency, reduce variance, and prevent reward hacking. In LLM reasoning, existing works also explore various solutions for learning effective process…

Machine Learning · Computer Science 2026-05-21 Xian Wu , Kaijie Zhu , Ying Zhang , Lun Wang , Wenbo Guo

Sequential recommendation (SR) has seen significant advancements with the help of Pre-trained Language Models (PLMs). Some PLM-based SR models directly use PLM to encode user historical behavior's text sequences to learn user…

Information Retrieval · Computer Science 2024-08-15 Zekai Qu , Ruobing Xie , Chaojun Xiao , Xingwu Sun , Zhanhui Kang

Recent years have seen considerable advancements in multi-step reasoning with Large Language Models (LLMs). The previous studies have elucidated the merits of integrating feedback or search mechanisms during model inference to improve the…

Computation and Language · Computer Science 2023-10-17 Qianli Ma , Haotian Zhou , Tingkai Liu , Jianbo Yuan , Pengfei Liu , Yang You , Hongxia Yang

Adeno-associated viral (AAV) vectors are widely used delivery platforms in gene therapy, and the design of improved capsids is key to expanding their therapeutic potential. A central challenge in AAV bioengineering, as in protein design…

Reparameterized diffusion models (RDMs) have recently matched autoregressive methods in protein generation, motivating their use for challenging tasks such as designing membrane proteins, which possess interleaved soluble and transmembrane…

Biomolecules · Quantitative Biology 2025-09-30 Shrey Goel , Peregrine M. Schray , Yinuo Zhang , Sophia Vincoff , Huong T. Kratochvil , Pranam Chatterjee

Reinforcement Learning (RL) has emerged as a transformative approach for aligning and enhancing Large Language Models (LLMs), addressing critical challenges in instruction following, ethical alignment, and reasoning capabilities. This…

Artificial Intelligence · Computer Science 2025-07-08 Saksham Sahai Srivastava , Vaneet Aggarwal

A plethora of protein language models have been released in recent years. Yet comparatively little work has addressed how to best sample from them to optimize desired biological properties. We fill this gap by proposing a flexible,…

Machine Learning · Computer Science 2026-05-08 Calvin McCarter , Nick Bhattacharya , Sebastian W. Ober , Hunter Elliott

Reinforcement Learning (RL) suffers from sample inefficiency in sparse reward domains, and the problem is further pronounced in case of stochastic transitions. To improve the sample efficiency, reward shaping is a well-studied approach to…

Machine Learning · Computer Science 2024-10-10 Siddhant Bhambri , Amrita Bhattacharjee , Durgesh Kalwar , Lin Guan , Huan Liu , Subbarao Kambhampati

Reinforcement Learning with Verifiable Rewards (RLVR) has recently emerged as a promising framework for improving reasoning abilities in Large Language Models (LLMs). However, policy optimized with binary verification prone to overlook…

Machine Learning · Computer Science 2025-10-14 Jinghao Zhang , Naishan Zheng , Ruilin Li , Dongzhou Cheng , Zheming Liang , Feng Zhao , Jiaqi Wang

In this paper, we survey recent advances in Reinforcement Learning (RL) for reasoning with Large Language Models (LLMs). RL has achieved remarkable success in advancing the frontier of LLM capabilities, particularly in addressing complex…

Preference alignment in Large Language Models (LLMs) has significantly improved their ability to adhere to human instructions and intentions. However, existing direct alignment algorithms primarily focus on relative preferences and often…

Machine Learning · Computer Science 2025-05-13 Shenao Zhang , Zhihan Liu , Boyi Liu , Yufeng Zhang , Yingxiang Yang , Yongfei Liu , Liyu Chen , Tao Sun , Zhaoran Wang

Understanding real-world videos with complex semantics and long temporal dependencies remains a fundamental challenge in computer vision. Recent progress in multimodal large language models (MLLMs) has demonstrated strong capabilities in…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Hongyu Li , Songhao Han , Yue Liao , Junfeng Luo , Jialin Gao , Shuicheng Yan , Si Liu