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Social media is becoming an increasingly important source of information to complement traditional pharmacovigilance methods. In order to identify signals of potential adverse drug reactions, it is necessary to first identify medical…

Artificial Intelligence · Computer Science 2015-04-28 Alejandro Metke-Jimenez , Sarvnaz Karimi

Detection of adversarial examples has been a hot topic in the last years due to its importance for safely deploying machine learning algorithms in critical applications. However, the detection methods are generally validated by assuming a…

Computer Vision and Pattern Recognition · Computer Science 2022-07-01 Federica Granese , Marine Picot , Marco Romanelli , Francisco Messina , Pablo Piantanida

For counterfactual policy evaluation, it is important to ensure that treatment parameters are relevant to policies in question. This is especially challenging under unobserved heterogeneity, as is well featured in the definition of the…

Econometrics · Economics 2023-08-08 Sukjin Han , Shenshen Yang

The average treatment effect (ATE) is commonly used to quantify the main effect of a binary treatment on an outcome. Extensions to continuous treatments are usually based on the dose-response curve or shift interventions, but both require…

Statistics Theory · Mathematics 2026-03-02 Oliver J. Hines , Karla Diaz-Ordaz , Stijn Vansteelandt

Natural science datasets frequently violate assumptions of independence. Samples may be clustered (e.g. by study site, subject, or experimental batch), leading to spurious associations, poor model fitting, and confounded analyses. While…

Machine Learning · Computer Science 2022-05-02 Kevin P. Nguyen , Albert Montillo

The automation of adverse drug reaction (ADR) detection in social media would revolutionize the practice of pharmacovigilance, supporting drug regulators, the pharmaceutical industry and the general public in ensuring the safety of the…

Computation and Language · Computer Science 2020-05-15 Amy Breden , Lee Moore

Adverse drug reaction (ADR) is widely concerned for public health issue. In this study we propose an original approach to detect the ADRs using feature matrix and feature selection. The experiments are carried out on the drug Aspirin. Major…

Computational Engineering, Finance, and Science · Computer Science 2014-09-03 Yihui liu , Uwe Aickelin

In personalised decision making, evidence is required to determine whether an action (treatment) is suitable for an individual. Such evidence can be obtained by modelling treatment effect heterogeneity in subgroups. The existing…

Methodology · Statistics 2022-06-24 Jiuyong Li , Lin Liu , Shisheng Zhang , Saisai Ma , Thuc Duy Le , Jixue Liu

The credibility revolution advances the use of research designs that permit identification and estimation of causal effects. However, understanding which mechanisms produce measured causal effects remains a challenge. The dominant current…

Econometrics · Economics 2026-04-08 Jiawei Fu , Tara Slough

Adverse drug reaction (ADR) is widely concerned for public health issue. In this study we propose an original approach to detect the ADRs using feature matrix and feature selection. The experiments are carried out on the drug Simvastatin.…

Computational Engineering, Finance, and Science · Computer Science 2013-07-05 Yihui Liu , Uwe Aickelin

We provide sufficient conditions for the identification of the heterogeneous treatment effects, defined as the conditional expectation for the differences of potential outcomes given the untreated outcome, under the nonignorable treatment…

Methodology · Statistics 2019-01-15 Keisuke Takahata , Takahiro Hoshino

Adverse Childhood Experiences (ACEs) are defined as a collection of highly stressful, and potentially traumatic, events or circumstances that occur throughout childhood and/or adolescence. They have been shown to be associated with…

Computation and Language · Computer Science 2022-08-25 Jinge Wu , Rowena Smith , Honghan Wu

Adverse drug interactions are a critical concern in pharmacovigilance, as both clinical trials and spontaneous reporting systems often lack the breadth to detect complex drug interactions. This study introduces a computational framework for…

Applications · Statistics 2025-04-02 Jules Bangard , Einar Holsbø , Kristian Svendsen , Vittorio Perduca , Etienne Birmelé

Polypharmacy, the concurrent use of multiple drugs to treat a single condition, is common in patients managing multiple or complex conditions. However, as more drugs are added to the treatment plan, the risk of adverse drug events (ADEs)…

Machine Learning · Computer Science 2025-06-12 Natalie Wang , Casey Overby Taylor

Adverse drug interactions are largely preventable causes of medical accidents, which frequently result in physician and emergency room encounters. The detection of drug interactions in a lab, prior to a drug's use in medical practice, is…

Machine Learning · Computer Science 2023-02-08 Bar Vered , Guy Shtar , Lior Rokach , Bracha Shapira

Social media has grown to be a crucial information source for pharmacovigilance studies where an increasing number of people post adverse reactions to medical drugs that are previously unreported. Aiming to effectively monitor various…

Machine Learning · Computer Science 2018-02-19 Shaika Chowdhury , Chenwei Zhang , Philip S. Yu

Adverse drug reaction (ADR) detection is an essential task in the medical field, as ADRs have a gravely detrimental impact on patients' health and the healthcare system. Due to a large number of people sharing information on social media…

Computation and Language · Computer Science 2023-08-21 Yunzhi Qiu , Xiaokun Zhang , Weiwei Wang , Tongxuan Zhang , Bo Xu , Hongfei Lin

The Average Treatment Effect (ATE) is a global measure of the effectiveness of an experimental treatment intervention. Classical methods of its estimation either ignore relevant covariates or do not fully exploit them. Moreover, past work…

Methodology · Statistics 2013-11-05 Emil Pitkin , Richard Berk , Lawrence Brown , Andreas Buja , Ed George , Kai Zhang , Linda Zhao

Mixed effects (ME) models inform a vast array of problems in the physical and social sciences, and are pervasive in meta-analysis. We consider ME models where the random effects component is linear. We then develop an efficient approach for…

Adversarial attacks are a type of attack on machine learning models where an attacker deliberately modifies the inputs to cause the model to make incorrect predictions. Adversarial attacks can have serious consequences, particularly in…

Machine Learning · Computer Science 2025-09-15 Prathyusha Devabhakthini , Sasmita Parida , Raj Mani Shukla , Suvendu Chandan Nayak , Tapadhir Das