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Reference information plays an essential role for making decisions under uncertainty, yet may vary across multiple data sources. In this paper, we study resource allocation in stochastic dynamic environments, where we perform information…

Optimization and Control · Mathematics 2024-11-05 Yanru Guo , Bo Zhou , Ruiwei Jiang , Xi , Yang , Siqian Shen

We address one of the important problems in Big Data, namely how to combine estimators from different subsamples by robust fusion procedures, when we are unable to deal with the whole sample. We propose a general framework based on the…

Statistics Theory · Mathematics 2018-04-06 Catherine Aaron , Alejandro Cholaquidis , Ricardo Fraiman , Badih Ghattas

Clinical randomized controlled trials (RCTs) collect hundreds of measurements spanning various metric types (e.g., laboratory tests, cognitive/motor assessments, etc.) across 100s-1000s of subjects to evaluate the effect of a treatment, but…

Machine Learning · Computer Science 2024-06-25 Sayeri Lala , Niraj K. Jha

Randomized Controlled Trials (RCT)s are relied upon to assess new treatments, but suffer from limited power to guide personalized treatment decisions. On the other hand, observational (i.e., non-experimental) studies have large and diverse…

Methodology · Statistics 2023-03-07 Zeshan Hussain , Ming-Chieh Shih , Michael Oberst , Ilker Demirel , David Sontag

Generation of realistic synthetic data has garnered considerable attention in recent years, particularly in the health research domain due to its utility in, for instance, sharing data while protecting patient privacy or determining optimal…

Other Statistics · Statistics 2025-01-30 Niki Z. Petrakos , Erica E. M. Moodie , Nicolas Savy

Hybrid randomized controlled trials (hybrid RCTs) integrate external control data, such as historical or concurrent data, with data from randomized trials. While numerous frequentist and Bayesian methods, such as the test-then-pool and…

Methodology · Statistics 2025-10-07 Han Chang Chiam , Franz König , Martin Posch

Augmented inverse probability weighting and G-computation with canonical generalized linear models have become increasingly popular for estimating average treatment effects (ATEs) in randomized experiments. These methods leverage outcome…

Methodology · Statistics 2026-03-13 Muluneh Alene , Stijn Vansteelandt , Kelly Van Lancker

Observational cohort studies are increasingly being used for comparative effectiveness research to assess the safety of therapeutics. Recently, various doubly robust methods have been proposed for average treatment effect estimation by…

Methodology · Statistics 2025-03-11 Xiaoqing Tan , Shu Yang , Wenyu Ye , Douglas E. Faries , Ilya Lipkovich , Zbigniew Kadziola

The ability to generalize experimental results from randomized control trials (RCTs) across locations is crucial for informing policy decisions in targeted regions. Such generalization is often hindered by the lack of identifiability due to…

Econometrics · Economics 2021-12-10 Xinkun Nie , Guido Imbens , Stefan Wager

Information from various data sources is increasingly available nowadays. However, some of the data sources may produce biased estimation due to commonly encountered biased sampling, population heterogeneity, or model misspecification. This…

Methodology · Statistics 2023-02-07 Ruoyu Wang , Qihua Wang , Wang Miao

Randomized Controlled Trials (RCTs) are the gold standard for evaluating the effect of new medical treatments. Treatments must pass stringent regulatory conditions in order to be approved for widespread use, yet even after the regulatory…

Machine Learning · Statistics 2025-03-13 Omer Noy Klein , Alihan Hüyük , Ron Shamir , Uri Shalit , Mihaela van der Schaar

We consider how increasingly available observational data can be used to improve the design of randomized controlled trials (RCTs). We seek to design a prospective RCT, with the intent of using an Empirical Bayes estimator to shrink the…

Methodology · Statistics 2022-04-15 Evan T. R. Rosenman , Luke Miratrix

Motivated by two case studies using primary care records from the Clinical Practice Research Datalink, we describe statistical methods that facilitate the analysis of tall data, with very large numbers of observations. Our focus is on…

Methodology · Statistics 2018-05-14 Kirsty Rhodes , Rebecca Turner , Rupert Payne , Ian White

The sharp and recent increase in the availability of data captured by different sensors combined with their considerably heterogeneous natures poses a serious challenge for the effective and efficient processing of remotely sensed data.…

We aim to generalize the results of a randomized controlled trial (RCT) to a target population with the help of some observational data. This is a problem of causal effect identification with multiple data sources. Challenges arise when the…

Methodology · Statistics 2022-06-15 Juha Karvanen

Considering the multimodal signals of search items is beneficial for retrieval effectiveness. Especially in web table retrieval (WTR) experiments, accounting for multimodal properties of tables boosts effectiveness. However, it still…

Information Retrieval · Computer Science 2023-10-19 Björn Engelmann , Timo Breuer , Philipp Schaer

Linear combination is a potent data fusion method in information retrieval tasks, thanks to its ability to adjust weights for diverse scenarios. However, achieving optimal weight training has traditionally required manual relevance…

Information Retrieval · Computer Science 2023-09-25 Qiuyu Xu , Yidong Huang , Shengli Wu , Adrian Moore

Forensic science suffers from a lack of studies with high-quality design, such as randomized controlled trials (RCT). Evidence in forensic science may be of insufficient quality, which is a major concern. Results from RCT are criticized for…

Computers and Society · Computer Science 2017-07-27 Vincent Laugier , Eric Stindel , Alcibiade Lichterowicz , Séverine Ansart , Thomas Lefèvre

We provide a novel characterization of semiparametric efficiency in a generic supervised learning setting where the outcome mean function -- defined as the conditional expectation of the outcome of interest given the other observed…

Methodology · Statistics 2025-04-22 Harrison H. Li

A Real-World Evidence (RWE) Scientific Working Group (SWG) of the American Statistical Association Biopharmaceutical Section (ASA BIOP) has been reviewing statistical considerations for the generation of RWE to support regulatory…

Applications · Statistics 2023-07-04 Jie Chen , Daniel Scharfstein , Hongwei Wang , Binbing Yu , Yang Song , Weili He , John Scott , Xiwu Lin , Hana Lee