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The development of deep neural networks has improved representation learning in various domains, including textual, graph structural, and relational triple representations. This development opened the door to new relation extraction beyond…

Computation and Language · Computer Science 2022-12-22 Masaki Asada

Accurately predicting drug-drug interactions (DDIs) is crucial for pharmaceutical research and clinical safety. Recent deep learning models often suffer from high computational costs and limited generalization across datasets. In this…

Biomolecules · Quantitative Biology 2025-04-01 Manel Gil-Sorribes , Alexis Molina

Drug combination therapy is a well-established strategy for disease treatment with better effectiveness and less safety degradation. However, identifying novel drug combinations through wet-lab experiments is resource intensive due to the…

Machine Learning · Computer Science 2023-01-18 Zhihang Hu , Qinze Yu , Yucheng Guo , Taifeng Wang , Irwin King , Xin Gao , Le Song , Yu Li

The Zero-Shot Learning (ZSL) task attempts to learn concepts without any labeled data. Unlike traditional classification/detection tasks, the evaluation environment is provided unseen classes never encountered during training. As such, it…

Computer Vision and Pattern Recognition · Computer Science 2022-11-18 Abhijit Suprem

Predicting drug-target interactions (DTI) is an essential part of the drug discovery process, which is an expensive process in terms of time and cost. Therefore, reducing DTI cost could lead to reduced healthcare costs for a patient. In…

Machine Learning · Computer Science 2019-08-20 Bonggun Shin , Sungsoo Park , Keunsoo Kang , Joyce C. Ho

Zero-Shot Stance Detection (ZSSD) identifies the attitude of the post toward unseen targets. Existing research using contrastive, meta-learning, or data augmentation suffers from generalizability issues or lack of coherence between text and…

Computation and Language · Computer Science 2025-11-06 Apoorva Upadhyaya , Wolfgang Nejdl , Marco Fisichella

Accurate prediction of drug-target interactions (DTI) is crucial for drug discovery. Recently, deep learning (DL) models for show promising performance for DTI prediction. However, these models can be difficult to use for both computer…

Machine Learning · Computer Science 2020-12-11 Kexin Huang , Tianfan Fu , Lucas Glass , Marinka Zitnik , Cao Xiao , Jimeng Sun

Traditional drug discovery processes are both time-consuming and require extensive professional expertise. With the accumulation of drug-target interaction (DTI) data from experimental studies, leveraging modern machine-learning techniques…

Quantitative Methods · Quantitative Biology 2024-12-12 Shuqi Li , Shufang Xie , Hongda Sun , Yuhan Chen , Tao Qin , Tianjun Ke , Rui Yan

Zero-shot learning (ZSL) aims to predict unseen classes whose samples have never appeared during training. One of the most effective and widely used semantic information for zero-shot image classification are attributes which are…

Computer Vision and Pattern Recognition · Computer Science 2023-02-17 Zhuo Chen , Yufeng Huang , Jiaoyan Chen , Yuxia Geng , Wen Zhang , Yin Fang , Jeff Z. Pan , Huajun Chen

Zero-Shot Learning (ZSL) focuses on classifying samples of unseen classes with only their side semantic information presented during training. It cannot handle real-life, open-world scenarios where there are test samples of unknown classes…

Computer Vision and Pattern Recognition · Computer Science 2023-07-10 Tianqi Li , Guansong Pang , Xiao Bai , Jin Zheng , Lei Zhou , Xin Ning

Zero-shot learning (ZSL) highly depends on a good semantic embedding to connect the seen and unseen classes. Recently, distributed word embeddings (DWE) pre-trained from large text corpus have become a popular choice to draw such a…

Computer Vision and Pattern Recognition · Computer Science 2017-07-19 Ruizhi Qiao , Lingqiao Liu , Chunhua Shen , Anton van den Hengel

Drug-drug interaction(DDI) prediction is an important task in the medical health machine learning community. This study presents a new method, multi-view graph contrastive representation learning for drug-drug interaction prediction,…

Machine Learning · Computer Science 2021-04-13 Yingheng Wang , Yaosen Min , Xin Chen , Ji Wu

Preventable adverse events as a result of medical errors present a growing concern in the healthcare system. As drug-drug interactions (DDIs) may lead to preventable adverse events, being able to extract DDIs from drug labels into a…

Computation and Language · Computer Science 2019-11-06 Tung Tran , Ramakanth Kavuluru , Halil Kilicoglu

Zero-shot learning (ZSL) refers to the problem of learning to classify instances from the novel classes (unseen) that are absent in the training set (seen). Most ZSL methods infer the correlation between visual features and attributes to…

Computer Vision and Pattern Recognition · Computer Science 2021-03-04 Zhe Liu , Yun Li , Lina Yao , Xianzhi Wang , Guodong Long

In zero-shot learning (ZSL) community, it is generally recognized that transductive learning performs better than inductive one as the unseen-class samples are also used in its training stage. How to generate pseudo labels for unseen-class…

Computer Vision and Pattern Recognition · Computer Science 2022-03-31 Bo Liu , Lihua Hu , Qiulei Dong , Zhanyi Hu

The discovery of drug-target interactions (DTIs) is a pivotal process in pharmaceutical development. Computational approaches are a promising and efficient alternative to tedious and costly wet-lab experiments for predicting novel DTIs from…

Artificial Intelligence · Computer Science 2023-03-22 Bin Liu , Jin Wang , Kaiwei Sun , Grigorios Tsoumakas

Obtaining common representations from different modalities is important in that they are interchangeable with each other in a classification problem. For example, we can train a classifier on image features in the common representations and…

Machine Learning · Computer Science 2016-12-30 Kuniaki Saito , Yusuke Mukuta , Yoshitaka Ushiku , Tatsuya Harada

Cold-start drug-target interaction (DTI) prediction focuses on interaction between novel drugs and proteins. Previous methods typically learn transferable interaction patterns between structures of drug and proteins to tackle it. However,…

Machine Learning · Computer Science 2025-10-07 Ziying Zhang , Yaqing Wang , Yuxuan Sun , Min Ye , Quanming Yao

Zero-shot domain adaptation (ZSDA) presents substantial challenges due to the lack of images in the target domain. Previous approaches leverage Vision-Language Models (VLMs) to tackle this challenge, exploiting their zero-shot learning…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Xiao Zhang , Fei Wei , Yong Wang , Wenda Zhao , Feiyi Li , Xiangxiang Chu

The Interaction between Drugs and Targets (DTI) in human body plays a crucial role in biomedical science and applications. As millions of papers come out every year in the biomedical domain, automatically discovering DTI knowledge from…

Computation and Language · Computer Science 2021-09-28 Yutai Hou , Yingce Xia , Lijun Wu , Shufang Xie , Yang Fan , Jinhua Zhu , Wanxiang Che , Tao Qin , Tie-Yan Liu