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In meta-analysis of diagnostic test accuracy, summary receiver operating characteristic (SROC) is a recommended method to summarize the discriminant capacity of a diagnostic test in the presence of study-specific cutoff values and the area…

Methodology · Statistics 2023-01-10 Yi Zhou , Ao Huang , Satoshi Hattori

Verification bias is a well-known problem that may occur in the evaluation of predictive ability of diagnostic tests. When a binary disease status is considered, various solutions can be found in the literature to correct inference based on…

Methodology · Statistics 2023-04-10 Khanh To Duc , Monica Chiogna , Gianfranco Adimari

The area under the curve (AUC) of the receiver operating characteristics curve (ROC) evaluates the separation between patients and nonpatients or discrimination. For risk prediction models these risk distributions can be derived from the…

Quantitative Methods · Quantitative Biology 2021-02-23 Ralph H. Stern

We provide a comprehensive theory of conducting in-sample statistical inference about receiver operating characteristic (ROC) curves that are based on predicted values from a first stage model with estimated parameters (such as a logit…

Econometrics · Economics 2021-12-06 Yu-Chin Hsu , Robert P. Lieli

Time-dependent Receiver Operating Characteristics (ROC) analysis is a standard method to evaluate the discriminative performance of biomarkers or risk scores for time-to-event outcomes. Extensions of this useful method to left-truncated…

Methodology · Statistics 2025-09-09 Kendrick Li , Mithun Kumar Acharjee

The Area Under the the Receiver Operating Characteristics (ROC) Curve, referred to as AUC, is a well-known performance measure in the supervised learning domain. Due to its compelling features, it has been employed in a number of studies to…

Machine Learning · Computer Science 2023-04-05 Pablo Andretta Jaskowiak , Ivan Gesteira Costa , Ricardo José Gabrielli Barreto Campello

The ROC curve is widely used to assess binary classifiers. Yet for some applications, such as alert systems for monitoring hospitalized patients, conventional ROC analysis cannot meet two key deployment needs: enforcing a constraint on…

Machine Learning · Computer Science 2026-04-03 Christopher Ratigan , Kyle Heuton , Carissa Wang , Lenore Cowen , Michael C. Hughes

The identification of biomarkers with high predictive accuracy is a crucial task in medical research, as it can aid clinicians in making early decisions, thereby reducing morbidity and mortality in high-risk populations. Time-dependent…

Methodology · Statistics 2025-10-22 María Xosé Rodríguez-Álvarez , Vanda Inácio

Everybody writes that ROC curves, a very common tool in binary classification problems, should be optimal, and in particular concave, non-decreasing and above the 45-degree line. Everybody uses ROC curves, theoretical and especially…

Methodology · Statistics 2019-08-01 Lidia Sacchetto , Mauro Gasparini

Receiver Operating Characteristic (ROC) curves are plots of true positive rate versus false positive rate which are used to evaluate binary classification algorithms. Because the Area Under the Curve (AUC) is a constant function of the…

Machine Learning · Computer Science 2023-02-23 Kyle R. Rust , Toby D. Hocking

A new semiparametric model of the ROC curve based on the resilience family or proportional reversed hazard family is proposed which is an alternative to the existing models. The resulting ROC curve and its summary indices (such as area…

Methodology · Statistics 2022-03-28 Ruhul Ali Khan

Receiver Operating Characteristic (ROC) curves are plots of true positive rate versus false positive rate which are useful for evaluating binary classification models, but difficult to use for learning since the Area Under the Curve (AUC)…

Machine Learning · Statistics 2021-07-06 Jonathan Hillman , Toby Dylan Hocking

We present a novel analytical framework to characterize the distribution of the conditional receiver operating characteristic (ROC) in radar systems operating within a realization of a Poisson field of interferers and clutters. While…

Information Theory · Computer Science 2025-05-28 Gourab Ghatak

The area under the ROC curve (AUC) is a widely used performance measure in machine learning. Increasingly, however, in several applications, ranging from ranking to biometric screening to medicine, performance is measured not in terms of…

Machine Learning · Computer Science 2016-11-29 Harikrishna Narasimhan , Shivani Agarwal

The area under the receiver operating characteristic curve (AUC) is often used to evaluate the performance of clinical prediction models. Recently, a more refined strategy has been proposed to examine a partial area under the curve (pAUC),…

Applications · Statistics 2016-06-22 Travis Gerke , Svitlana Tyekucheva , Lorelei Mucci , Giovanni Parmigiani

Most binary classifiers work by processing the input to produce a scalar response and comparing it to a threshold value. The various measures of classifier performance assume, explicitly or implicitly, probability distributions $P_s$ and…

Machine Learning · Computer Science 2019-09-24 Luma Omar , Ioannis Ivrissimtzis

Computer-aided drug discovery is an essential component of modern drug development. Therein, deep learning has become an important tool for rapid screening of billions of molecules in silico for potential hits containing desired chemical…

Feature selection aims to select the smallest subset of features for a specified level of performance. The optimal achievable classification performance on a feature subset is summarized by its Receiver Operating Curve (ROC). When infinite…

Machine Learning · Computer Science 2013-01-18 Frans Coetzee , Steve Lawrence , C. Lee Giles

Risk prediction that capitalizes on emerging genetic findings holds great promise for improving public health and clinical care. However, recent risk prediction research has shown that predictive tests formed on existing common genetic…

Machine Learning · Computer Science 2025-08-20 Changshuai Wei , Qing Lu

In high-stakes risk prediction, quantifying uncertainty through interval-valued predictions is essential for reliable decision-making. However, standard evaluation tools like the receiver operating characteristic (ROC) curve and the area…

Machine Learning · Computer Science 2026-02-05 Yuqi Li , Matthew M. Engelhard