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The adaptation of large asexual populations is hampered by the competition between independently arising beneficial mutations in different individuals, which is known as clonal interference. Fisher and Muller proposed that recombination…

Populations and Evolution · Quantitative Biology 2013-08-16 Su-Chan Park , Joachim Krug

Populations evolving under the joint influence of recombination and resampling (traditionally known as genetic drift) are investigated. First, we summarise and adapt a deterministic approach, as valid for infinite populations, which assumes…

Populations and Evolution · Quantitative Biology 2009-02-20 Ellen Baake , Inke Herms

We consider a stochastic individual-based model of adaptive dynamics for an asexually reproducing population with mutation. Biologically motivated by the influence of seasons or the variation of drug concentration during medical treatment,…

Probability · Mathematics 2025-03-26 Manuel Esser , Anna Kraut

The dynamics of adaptation is difficult to predict because it is highly stochastic even in large populations. The uncertainty emerges from number fluctuations, called genetic drift, arising in the small number of particularly fit…

Populations and Evolution · Quantitative Biology 2015-06-30 Oskar Hallatschek , Lukas Geyrhofer

We consider a dynamic metapopulation involving one large population of size N surrounded by colonies of size \varepsilon_NN, usually called peripheral isolates in ecology, where N\to\infty and \varepsilon_N\to 0 in such a way that…

Probability · Mathematics 2013-03-15 Amaury Lambert , Chunhua Ma

The Wright-Fisher model and the Moran model are both widely used in population genetics. They describe the time evolution of the frequency of an allele in a well-mixed population with fixed size. We propose a simple and tractable model…

Populations and Evolution · Quantitative Biology 2024-12-30 Arthur Alexandre , Alia Abbara , Cecilia Fruet , Claude Loverdo , Anne-Florence Bitbol

The accumulation of adaptive mutations is essential for survival in novel environments. However, in clonal populations with a high mutational supply, the power of natural selection is expected to be limited. This is due to clonal…

Populations and Evolution · Quantitative Biology 2014-04-04 João Barroso-Batista , Ana Sousa , Marta Lourenço , Marie-Louise Bergman , Jocelyne Demengeot , Karina B. Xavier , Isabel Gordo

Genetic variation in a population can sometimes arise so fast as to modify ecosystem dynamics. Such phenomena have been observed in natural predator-prey systems, and characterized in the laboratory as showing unusual phase relationships in…

Populations and Evolution · Quantitative Biology 2025-03-25 Hong-Yan Shih , Nigel Goldenfeld

Evolutionary graph theory studies the evolutionary dynamics in a population structure given as a connected graph. Each node of the graph represents an individual of the population, and edges determine how offspring are placed. We consider…

Neural and Evolutionary Computing · Computer Science 2017-06-22 Krishnendu Chatterjee , Rasmus Ibsen-Jensen , Martin A. Nowak

We consider the Moran process, as generalized by Lieberman, Hauert and Nowak (Nature, 433:312--316, 2005). A population resides on the vertices of a finite, connected, undirected graph and, at each time step, an individual is chosen at…

Computational Complexity · Computer Science 2014-03-21 Josep Díaz , Leslie Ann Goldberg , George B. Mertzios , David Richerby , Maria Serna , Paul G. Spirakis

A Hamilton-Jacobi formulation has been established previously for phenotypically structured population models where the solution concentrates as Dirac masses in the limit of small diffusion. Is it possible to extend this approach to spatial…

Analysis of PDEs · Mathematics 2014-02-24 Sepideh Mirrahimi

We study a continuous time model for the frequency distribution of an infinitely large asexual population in which both beneficial and deleterious mutations occur and the fitness is additive. When beneficial mutations are ignored, the exact…

Populations and Evolution · Quantitative Biology 2016-10-27 Kavita Jain , Sona John

Understanding under what conditions interacting populations, whether they be plants, animals, or viral particles, coexist is a question of theoretical and practical importance in population biology. Both biotic interactions and…

Populations and Evolution · Quantitative Biology 2011-04-26 Sebastian J. Schreiber , Michel Benaïm , Kolawolé A. S. Atchadé

Microbial dormancy is an evolutionary trait that has emerged independently at various positions across the tree of life. It describes the ability of a microorganism to switch to a metabolically inactive state that can withstand unfavorable…

Probability · Mathematics 2020-04-08 Jochen Blath , András Tóbiás

The aim of this paper is to study the large population limit of a binary branching particle system with Moran type interactions: we introduce a new model where particles evolve, reproduce and die independently and, with a probability that…

Probability · Mathematics 2024-04-12 Alexander M. G. Cox , Emma Horton , Denis Villemonais

Evolutionary models for populations of constant size are frequently studied using the Moran model, the Wright-Fisher model, or their diffusion limits. When evolution is neutral, a random genealogy given through Kingman's coalescent is used…

Populations and Evolution · Quantitative Biology 2012-07-31 Peter Pfaffelhuber , Benedikt Vogt

The evolution of an infinite population of interacting point entities placed in $\mathbb{R}^d$ is studied. The elementary evolutionary acts are death of an entity with rate that includes a competition term and independent fission into two…

Dynamical Systems · Mathematics 2018-08-15 Yuri Kozitsky , Agnieszka Tanas

Evolution occurs in populations of reproducing individuals. It is well known that population structure can affect evolutionary dynamics. Traditionally, natural selection is studied between mutants that differ in reproductive rate, but are…

Populations and Evolution · Quantitative Biology 2021-11-23 Josef Tkadlec , Kamran Kaveh , Krishnendu Chatterjee , Martin A. Nowak

We explore the connection between evolution and large-deviation theory. To do so, we study evolutionary dynamics in which individuals experience mutations, reproduction, and selection using variants of the Moran model. We show that, in the…

Populations and Evolution · Quantitative Biology 2026-01-09 Sara Dal Cengio , Quentin Laurenceau , Vivien Lecomte , Charline Smadi , Julien Tailleur

We are interested in modelling Darwinian evolution, resulting from the interplay of phenotypic variation and natural selection through ecological interactions. Our models are rooted in the microscopic, stochastic description of a population…

Probability · Mathematics 2016-08-16 Nicolas Champagnat , Régis Ferrière , Sylvie Méléard