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Chest X-ray imaging is crucial for diagnosing pulmonary and cardiac diseases, yet its interpretation demands extensive clinical experience and suffers from inter-observer variability. While deep learning models offer high diagnostic…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Chee Ng , Liliang Sun , Shaoqing Tang

An essential step in deploying medical imaging models is ensuring alignment with clinical knowledge and interpretability. We focus on mapping clinical concepts into the latent space of generative models to identify Concept Activation…

Image and Video Processing · Electrical Eng. & Systems 2025-06-05 Bulat Maksudov , Kathleen Curran , Alessandra Mileo

Vision-language models (VLMs) have shown strong promise for medical image analysis, but most remain opaque, offering predictions without the transparent, stepwise reasoning clinicians rely on. We present a framework that brings…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Andriy Myronenko , Dong Yang , Baris Turkbey , Mariam Aboian , Sena Azamat , Esra Akcicek , Hongxu Yin , Pavlo Molchanov , Marc Edgar , Yufan He , Pengfei Guo , Yucheng Tang , Daguang Xu

Model explainability is essential for the creation of trustworthy Machine Learning models in healthcare. An ideal explanation resembles the decision-making process of a domain expert and is expressed using concepts or terminology that is…

Machine Learning · Computer Science 2021-07-14 Sumedha Singla , Stephen Wallace , Sofia Triantafillou , Kayhan Batmanghelich

Automated interpretation of chest X-rays (CXR) is a critical task with the potential to significantly improve clinical workflow and patient care. While recent advances in multimodal foundation models have shown promise, effectively…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Alexander Davis , Rafael Souza , Jia-Hao Lim

Concept Bottleneck Models (CBMs) in medical imaging aim to improve model interpretability by predicting intermediate clinical concepts before final diagnoses. However, most existing CBMs treat concepts as discriminative predictors of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Amy Rafferty , Rishi Ramaesh , Ajitha Rajan

Deep learning models used in medical image analysis are prone to raising reliability concerns due to their black-box nature. To shed light on these black-box models, previous works predominantly focus on identifying the contribution of…

Image and Video Processing · Electrical Eng. & Systems 2022-07-18 Matan Atad , Vitalii Dmytrenko , Yitong Li , Xinyue Zhang , Matthias Keicher , Jan Kirschke , Bene Wiestler , Ashkan Khakzar , Nassir Navab

In this paper, our focus is on constructing models to assist a clinician in the diagnosis of COVID-19 patients in situations where it is easier and cheaper to obtain X-ray data than to obtain high-quality images like those from CT scans.…

Image and Video Processing · Electrical Eng. & Systems 2021-02-15 Rishab Khincha , Soundarya Krishnan , Tirtharaj Dash , Lovekesh Vig , Ashwin Srinivasan

Concept-based interpretability methods are a popular form of explanation for deep learning models which provide explanations in the form of high-level human interpretable concepts. These methods typically find concept activation vectors…

Machine Learning · Computer Science 2024-08-19 Angus Nicolson , Yarin Gal , J. Alison Noble

Vision-language models (VLMs) have recently shown remarkable zero-shot performance in medical image understanding, yet their grounding ability, the extent to which textual concepts align with visual evidence, remains underexplored. In the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Haozhe Luo , Shelley Zixin Shu , Ziyu Zhou , Sebastian Otalora , Mauricio Reyes

Deep learning shows promise for medical image analysis but lacks interpretability, hindering adoption in healthcare. Attribution techniques that explain model reasoning may increase trust in deep learning among clinical stakeholders. This…

Machine Learning · Computer Science 2023-08-08 Yusuf Brima , Marcellin Atemkeng

Large Vision Language Models (LVLMs) show promise in medical applications, but their inability to faithfully ground responses in visual evidence raises serious concerns about clinical trustworthiness. While visual attribution methods are…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Guangzhi Xiong , Qiao Jin , Sanchit Sinha , Zhiyong Lu , Aidong Zhang

Deep learning models show significant potential for advancing AI-assisted medical diagnostics, particularly in detecting lung cancer through medical image modalities such as chest X-rays. However, the black-box nature of these models poses…

Machine Learning · Computer Science 2025-03-31 Amy Rafferty , Rishi Ramaesh , Ajitha Rajan

Chest X-Ray (CXR) is a widely used clinical imaging modality and has a pivotal role in the diagnosis and prognosis of various lung and heart related conditions. Conventional automated clinical diagnostic tool design strategies relying on…

Image and Video Processing · Electrical Eng. & Systems 2024-07-26 Abhijeet Parida , Daniel Capellan-Martin , Sara Atito , Muhammad Awais , Maria J. Ledesma-Carbayo , Marius G. Linguraru , Syed Muhammad Anwar

Chest X-rays play a pivotal role in diagnosing respiratory diseases such as pneumonia, tuberculosis, and COVID-19, which are prevalent and present unique diagnostic challenges due to overlapping visual features and variability in image…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Yiming Lei , Michael Nguyen , Tzu Chia Liu , Hyounkyun Oh

Concept-based models aim to explain model decisions with human-understandable concepts. However, most existing approaches treat concepts as numerical attributes, without providing complementary visual explanations that could localize the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Cristiano Patrício , Luís F. Teixeira , João C. Neves

This study comprehensively explores knowledge distillation frameworks for COVID-19 and lung cancer classification using chest X-ray (CXR) images. We employ high-capacity teacher models, including VGG19 and lightweight Vision Transformers…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Aqib Nazir Mir , Danish Raza Rizvi

We propose a deep learning based method for classification of commonly occurring pathologies in chest X-ray images. The vast number of publicly available chest X-ray images provides the data necessary for successfully employing deep…

Image and Video Processing · Electrical Eng. & Systems 2020-06-24 Mohammad S. Majdi , Khalil N. Salman , Michael F. Morris , Nirav C. Merchant , Jeffrey J. Rodriguez

Artificial intelligence (AI)-based chest X-ray (CXR) interpretation assistants have demonstrated significant progress and are increasingly being applied in clinical settings. However, contemporary medical AI models often adhere to a…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Jinquan Guan , Qi Chen , Lizhou Liang , Yuhang Liu , Vu Minh Hieu Phan , Minh-Son To , Jian Chen , Yutong Xie

Report generation models offer fine-grained textual interpretations of medical images like chest X-rays, yet they often lack interactivity (i.e. the ability to steer the generation process through user queries) and localized…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Philip Müller , Georgios Kaissis , Daniel Rueckert
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