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The growing use of large language models (LLMs) for biomedical question answering raises concerns about the accuracy and evidentiary support of their responses. To address this, we present Answered with Evidence, a framework for evaluating…

Machine Learning · Computer Science 2025-07-08 Julian D Baldwin , Christina Dinh , Arjun Mukerji , Neil Sanghavi , Saurabh Gombar

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Lab results are often confusing and hard to understand. Large language models (LLMs) such as ChatGPT have opened a promising avenue for patients to get their questions answered. We aim to assess the feasibility of using LLMs to generate…

Computation and Language · Computer Science 2024-04-23 Zhe He , Balu Bhasuran , Qiao Jin , Shubo Tian , Karim Hanna , Cindy Shavor , Lisbeth Garcia Arguello , Patrick Murray , Zhiyong Lu

Large Language Models (LLMs) have shown versatility in various Natural Language Processing (NLP) tasks, including their potential as effective question-answering systems. However, to provide precise and relevant information in response to…

Computation and Language · Computer Science 2024-09-09 Sriram Veturi , Saurabh Vaichal , Reshma Lal Jagadheesh , Nafis Irtiza Tripto , Nian Yan

Despite the potential of Large Language Models (LLMs) in medicine, they may generate responses lacking supporting evidence or based on hallucinated evidence. While Retrieval Augment Generation (RAG) is popular to address this issue, few…

Large language models (LLMs) have demonstrated powerful text generation capabilities, bringing unprecedented innovation to the healthcare field. While LLMs hold immense promise for applications in healthcare, applying them to real clinical…

Computation and Language · Computer Science 2023-10-16 Rui Yang , Edison Marrese-Taylor , Yuhe Ke , Lechao Cheng , Qingyu Chen , Irene Li

Generative Large Language Models (LLMs) hold significant promise in healthcare, demonstrating capabilities such as passing medical licensing exams and providing clinical knowledge. However, their current use as information retrieval tools…

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

Large Language Models (LLMs) show great promise as a powerful tool for scientific literature exploration. However, their effectiveness in providing scientifically accurate and comprehensive answers to complex questions within specialized…

Evidence-based medicine (EBM) is central to high-quality care, but remains difficult to implement in fast-paced primary care settings. Physicians face short consultations, increasing patient loads, and lengthy guideline documents that are…

Computation and Language · Computer Science 2026-03-26 Zongliang Ji , Ziyang Zhang , Xincheng Tan , Matthew Thompson , Anna Goldenberg , Carl Yang , Rahul G. Krishnan , Fan Zhang

Background: Large Language Models (LLMs) are transforming artificial intelligence applications in healthcare due to their ability to understand, generate, and summarize complex medical text. They offer valuable support to clinicians,…

Computation and Language · Computer Science 2026-04-14 Subin Santhosh , Farwa Abbas , Hussain Ahmad , Claudia Szabo

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

Large Language Models (LLMs) have demonstrated remarkable performance across various information-seeking and reasoning tasks. These computational systems drive state-of-the-art dialogue systems, such as ChatGPT and Bard. They also carry…

Computation and Language · Computer Science 2023-10-13 Siyuan Brandon Loh , Aravind Sesagiri Raamkumar

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

Computation and Language · Computer Science 2024-07-09 Bojana Bašaragin , Adela Ljajić , Darija Medvecki , Lorenzo Cassano , Miloš Košprdić , Nikola Milošević

Large language models (LLMs), such as ChatGPT, are able to generate human-like, fluent responses for many downstream tasks, e.g., task-oriented dialog and question answering. However, applying LLMs to real-world, mission-critical…

Computation and Language · Computer Science 2023-03-10 Baolin Peng , Michel Galley , Pengcheng He , Hao Cheng , Yujia Xie , Yu Hu , Qiuyuan Huang , Lars Liden , Zhou Yu , Weizhu Chen , Jianfeng Gao

This study evaluates the performance of several Large Language Models (LLMs) on MedRedQA, a dataset of consumer-based medical questions and answers by verified experts extracted from the AskDocs subreddit. While LLMs have shown proficiency…

Computation and Language · Computer Science 2025-01-03 Moaiz Abrar , Yusuf Sermet , Ibrahim Demir

The proliferation of Large Language Models (LLMs) in high-stakes applications such as medical (self-)diagnosis and preliminary triage raises significant ethical and practical concerns about the effectiveness, appropriateness, and possible…

Computers and Society · Computer Science 2025-06-18 Bonam Mingole , Aditya Majumdar , Firdaus Ahmed Choudhury , Jennifer L. Kraschnewski , Shyam S. Sundar , Amulya Yadav

Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve…

Computation and Language · Computer Science 2025-07-11 Sabine Felde , Rüdiger Buchkremer , Gamal Chehab , Christian Thielscher , Jörg HW Distler , Matthias Schneider , Jutta G. Richter

Large language models (LLMs) have been widely used for various tasks and applications. However, LLMs and fine-tuning are limited to the pre-trained data. For example, ChatGPT's world knowledge until 2021 can be outdated or inaccurate. To…

Computation and Language · Computer Science 2025-04-24 Ahsan Bilal , Beiyu Lin

Large Language Models (LLMs), although powerful in general domains, often perform poorly on domain-specific tasks such as medical question answering (QA). In addition, LLMs tend to function as "black-boxes", making it challenging to modify…

Computation and Language · Computer Science 2024-08-19 Yucheng Shi , Shaochen Xu , Tianze Yang , Zhengliang Liu , Tianming Liu , Quanzheng Li , Xiang Li , Ninghao Liu
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