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Much of studies on neural computation are based on network models of static neurons that produce analog output, despite the fact that information processing in the brain is predominantly carried out by dynamic neurons that produce discrete…

Neurons and Cognition · Quantitative Biology 2017-06-21 Dongsung Huh , Terrence J. Sejnowski

The brain can efficiently learn a wide range of tasks, motivating the search for biologically inspired learning rules for improving current artificial intelligence technology. Most biological models are composed of point neurons, and cannot…

Neurons and Cognition · Quantitative Biology 2026-04-13 Cristiano Capone , Cosimo Lupo , Paolo Muratore , Pier Stanislao Paolucci

Foundation models are transforming neuroscience but are often prohibitively large, data-hungry, and difficult to deploy. Here, we introduce BrainSymphony, a lightweight and parameter-efficient foundation model with plug-and-play integration…

Quantitative Methods · Quantitative Biology 2026-02-13 Moein Khajehnejad , Forough Habibollahi , Devon Stoliker , Adeel Razi

Multimodal MRI offers complementary multi-scale information to characterize the brain structure. However, it remains challenging to effectively integrate multimodal MRI while achieving neuroscience interpretability. Here we propose to use…

Neurons and Cognition · Quantitative Biology 2025-12-15 Chengzhi Xia , Jianwei Chen , Yixuan Jiang , Qi Yan , Chao Li

Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

Neural and Evolutionary Computing · Computer Science 2020-05-05 Qiang Yu , Shenglan Li , Huajin Tang , Longbiao Wang , Jianwu Dang , Kay Chen Tan

A complete understanding of the brain requires an integrated description of the numerous scales of neural organization. It means studying the interplay of genes, synapses, and even whole brain regions which ultimately leads to different…

Neurons and Cognition · Quantitative Biology 2022-08-09 Charley Presigny , Fabrizio De Vico Fallani

State-of-the-art simulations of detailed neural models follow the Bulk Synchronous Parallel execution model. Execution is divided in equidistant communication intervals, equivalent to the shortest synaptic delay in the network. Neurons…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-06-05 Bruno Magalhães , Michael Hines , Thomas Sterling , Felix Schuermann

This research focuses on an innovative task of extracting equations from incomplete data, moving away from traditional methods used for complete solutions. The study addresses the challenge of extracting equations from data, particularly in…

Neurons and Cognition · Quantitative Biology 2024-07-02 Kuratov Andrey

Classification of biological neuron types and networks poses challenges to the full understanding of the brain's organisation and functioning. In this paper, we develop a novel objective classification model of biological neuronal types and…

Neurons and Cognition · Quantitative Biology 2020-03-31 Michael Taynnan Barros , Harun Siljak , Peter Mullen , Constantinos Papadias , Jari Hyttinen , Nicola Marchetti

Multimodal deep learning has been used to predict clinical endpoints and diagnoses from clinical routine data. However, these models suffer from scaling issues: they have to learn pairwise interactions between each piece of information in…

There has been a strong push recently to examine biological scale simulations of neuromorphic algorithms to achieve stronger inference capabilities. This paper presents a set of piecewise linear spiking neuron models, which can reproduce…

Machine Learning · Computer Science 2012-12-18 Hamid Soleimani , Arash Ahmadi , Mohammad Bavandpour

The massively parallel nature of biological information processing plays an important role for its superiority to human-engineered computing devices. In particular, it may hold the key to overcoming the von Neumann bottleneck that limits…

Brain network analysis has emerged as pivotal method for gaining a deeper understanding of brain functions and disease mechanisms. Despite the existence of various network construction approaches, shortcomings persist in the learning of…

Computer Vision and Pattern Recognition · Computer Science 2023-11-10 Yongcheng Zong , Shuqiang Wang

Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data. Here we show that a single self-supervised representation can…

Machine Learning · Computer Science 2026-05-27 Yizhou Wu , Shansong Wang , Yuheng Li , Mojtaba Safari , Mingzhe Hu , Chih-Wei Chang , Harini Veeraraghavan , Xiaofeng Yang

Diverse scientific and engineering research areas deal with discrete, time-stamped changes in large systems of interacting delay differential equations. Simulating such complex systems at scale on high-performance computing clusters demands…

In resent years, the software ecosystem for numerical simulation still remains fragmented, with different algorithms and discretization methods often implemented in isolation, each with distinct data structures and programming conventions.…

Numerical Analysis · Mathematics 2026-03-10 Yangyang Zheng , Huayi Wei , Yunqing Huang , Chunyu Chen , Tian Tian , Hanbin Liu , Wenbin Wang , Liang He

The growing interest in brain-inspired computational models arises from the remarkable problem-solving efficiency of the human brain. Action recognition, a complex task in computational neuroscience, has received significant attention due…

Neural and Evolutionary Computing · Computer Science 2024-06-18 Alireza Nadafian , Milad Mozafari , Timothée Masquelier , Mohammad Ganjtabesh

Recent advances at the intersection of control theory, neuroscience, and machine learning have revealed novel mechanisms by which dynamical systems perform computation. These advances encompass a wide range of conceptual, mathematical, and…

Machine Learning · Computer Science 2026-04-10 Arthur N. Montanari , Francesco Bullo , Dmitry Krotov , Adilson E. Motter

Differentiable simulators provide an avenue for closing the sim-to-real gap by enabling the use of efficient, gradient-based optimization algorithms to find the simulation parameters that best fit the observed sensor readings. Nonetheless,…

Robotics · Computer Science 2021-05-21 Eric Heiden , David Millard , Erwin Coumans , Yizhou Sheng , Gaurav S. Sukhatme