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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a rapid motor decline, leading to respiratory failure and subsequently to death. In this context, researchers have sought for models to automatically…

Machine Learning · Computer Science 2019-07-31 Telma Pereira , Sofia Pires , Marta Gromicho , Susana Pinto , Mamede de Carvalho , Sara C. Madeira

The analysis of speech measures in individuals with amyotrophic lateral sclerosis (ALS) can provide essential information for early diagnosis and tracking disease progression. However, current methods for extracting speech and pause…

Sound · Computer Science 2022-08-24 Saeid Alavi Naeini , Leif Simmatis , Yana Yunusova , Babak Taati

Amyotrophic lateral sclerosis (ALS) is incurable neurological disorder with rapidly progressive course. Common early symptoms of ALS are difficulty in swallowing and speech. However, early acoustic manifestation of speech and voice symptoms…

Sound · Computer Science 2021-01-12 Maxim Vashkevich , Yulia Rushkevich

Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of the motor neurons that causes progressive paralysis in patients. Current treatment options aim to prolong survival and improve quality of life. However, due to the…

Quantitative Methods · Quantitative Biology 2025-11-20 Christian Marius Lillelund , Sanjay Kalra , Russell Greiner

The upper motor neuron dysfunction in amyotrophic lateral sclerosis was quantified using triple stimulation and more focal transcranial magnetic stimulation techniques that were developed to reduce recording variability. These measurements…

Neurons and Cognition · Quantitative Biology 2016-09-29 Rahul Remanan , Viktor Sukhotskiy , Mona Shahbazi , Edward P. Furlani , Dale J. Lange

Recent advances in Artificial Intelligence (AI) and the exploration of noninvasive, objective biomarkers, such as speech signals, have encouraged the development of algorithms to support the early diagnosis of neurodegenerative diseases,…

Amyotrophic Lateral Sclerosis (ALS) is characterized as a rapidly progressive neurodegenerative disease that presents individuals with limited treatment options in the realm of medical interventions and therapies. The disease showcases a…

Machine Learning · Computer Science 2024-07-12 Ritesh Mehta , Aleksandar Pramov , Shashank Verma

We propose a cloud-based multimodal dialog platform for the remote assessment and monitoring of Amyotrophic Lateral Sclerosis (ALS) at scale. This paper presents our vision, technology setup, and an initial investigation of the efficacy of…

Amyotrophic Lateral Sclerosis (ALS) constitutes a progressive neurodegenerative disease with varying symptoms, including decline in speech intelligibility. Existing studies, which recognize dysarthria in ALS patients by predicting the…

Machine Learning · Computer Science 2025-03-05 Loukas Ilias , Dimitris Askounis

On average the lack of biological markers causes a one year diagnostic delay to detect amyotrophic lateral sclerosis (ALS). To improve the diagnostic process an automatic voice assessment based on acoustic analysis can be used. The purpose…

Sound · Computer Science 2020-03-25 Maxim Vashkevich , Alexander Petrovsky , Yuliya Rushkevich

The analysis of speech in individuals with amyotrophic lateral sclerosis is a powerful tool to support clinicians in the assessment of bulbar dysfunction. However, current methods used in clinical practice consist of subjective evaluations…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-28 Francesco Pierotti , Andrea Bandini

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder involving motor neuron degeneration. Significant research has begun to establish brain magnetic resonance imaging (MRI) as a potential biomarker to diagnose and…

Amyotrophic lateral sclerosis (ALS), a progressive neuromuscular degenerative disease, severely restricts patient communication capacity within a few years of onset, resulting in a significant deterioration of quality of life. The P300…

Human-Computer Interaction · Computer Science 2024-10-22 Nithin Parthasarathy , James Soetedjo , Saarang Panchavati , Nitya Parthasarathy , Corey Arnold , Nader Pouratian , William Speier

Survival prediction with small sets of features is a highly relevant topic for decision-making in clinical practice. I describe a method for predicting survival of amyotrophic lateral sclerosis (ALS) patients that was developed as a…

Applications · Statistics 2016-12-05 Christoph Kurz

Lipreading or visually recognizing speech from the mouth movements of a speaker is a challenging and mentally taxing task. Unfortunately, multiple medical conditions force people to depend on this skill in their day-to-day lives for…

Computer Vision and Pattern Recognition · Computer Science 2021-11-04 Bipasha Sen , Aditya Agarwal , Rudrabha Mukhopadhyay , Vinay Namboodiri , C V Jawahar

Identifying Amyotrophic Lateral Sclerosis (ALS) in its early stages is essential for establishing the beginning of treatment, enriching the outlook, and enhancing the overall well-being of those affected individuals. However, early…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Nícolas Barbosa Gomes , Arissa Yoshida , Mateus Roder , Guilherme Camargo de Oliveira , João Paulo Papa

Amyotrophic lateral sclerosis (ALS) is a severe disease with a typical survival of 3-5 years after symptom onset. Current treatments offer only limited life extension, and the variability in patient responses highlights the need for…

Machine Learning · Computer Science 2025-11-05 Guillaume Tejedor , Veronika Peralta , Nicolas Labroche , Patrick Marcel , Hélène Blasco , Hugo Alarcan

Background: An early diagnosis together with an accurate disease progression monitoring of multiple sclerosis is an important component of successful disease management. Prior studies have established that multiple sclerosis is correlated…

Audio and Speech Processing · Electrical Eng. & Systems 2021-09-28 Emil Svoboda , Tomáš Bořil , Jan Rusz , Tereza Tykalová , Dana Horáková , Charles R. G. Guttman , Krastan B. Blagoev , Hiroto Hatabu , Vlad I. Valtchinov

Although personalized automatic speech recognition (ASR) models have recently been designed to recognize even severely impaired speech, model performance may degrade over time for persons with degenerating speech. The aims of this study…

Audio and Speech Processing · Electrical Eng. & Systems 2022-11-02 Katrin Tomanek , Katie Seaver , Pan-Pan Jiang , Richard Cave , Lauren Harrel , Jordan R. Green

Amyotrophic lateral sclerosis (ALS) severely impairs patients' ability to communicate, often leading to a decline in their quality of life within a few years of diagnosis. The P300 speller brain-computer interface (BCI) offers an…

Computation and Language · Computer Science 2024-05-24 Nithin Parthasarathy , James Soetedjo , Saarang Panchavati , Nitya Parthasarathy , Corey Arnold , Nader Pouratian , William Speier
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