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Nano-indentation based on, e.g., atomic force microscopy (AFM), can measure single cell elasticity with high spatial resolution and sensitivity, but relating the data to cell mechanical properties depends on modeling that requires knowledge…

Biological Physics · Physics 2021-09-29 Yue Cui , Weng-Hang Leong , Chu-Feng Liu , Kangwei Xia , Xi Feng , Csilla Gergely , Ren-Bao Liu , Quan Li

Information of material deformation upon loading is critical to evaluate mechanical properties of materials in general, and key to understand fundamental mechano-stimuli induced response of live systems in particular. Conventionally, such…

Mesoscale and Nanoscale Physics · Physics 2019-09-11 Kangwei Xia , Chu-Feng Liu , Weng-Hang Leong , Man-Hin Kwok , Zhi-Yuan Yang , Xi Feng , Ren-Bao Liu , Quan Li

Traditional cellular force-sensing techniques, such as traction force microscopy (TFM), are predominantly limited to measuring linear tractions, overlooking and technically unable to capture the nanoscale torsional forces that are critical…

The precise measurement of mechanical stress at the nanoscale is of fundamental and technological importance. In principle, all six independent variables of the stress tensor, which describe the direction and magnitude of…

Nanoindentation involves probing a hard diamond tip into a material, where the load and the displacement experienced by the tip is recorded continuously. This load-displacement data is a direct function of material's innate stress-strain…

Computational Engineering, Finance, and Science · Computer Science 2016-12-13 Salah U. Hamim

The constant interplay and information exchange between cells and their micro-environment are essential to their survival and ability to execute biological functions. To date, a few leading technologies such as traction force microscopy,…

Cell Behavior · Quantitative Biology 2023-06-29 Feng Xu , Shuxiang Zhang , Linjie Ma , Yong Hou , Jie Li , Andrej Denisenko , Zifu Li , Joachim Spatz , Jörg Wrachtrup , Qiang Wei , Zhiqin Chu

Structural damage detection using non-contact sensing remains a challenging problem in structural health monitoring. This study presents a data-driven framework based on Dynamic Mode Decomposition (DMD) for extracting structural dynamics…

Systems and Control · Electrical Eng. & Systems 2026-05-05 R K B M Rizmi , Shabbir Ahmed

Cellular traction forces are conventionally measured by tracking the displacement of beads or micropillars, an approach fundamentally limited by optical diffraction and the classical Euler-Bernoulli beam assumption, which is accurate only…

Optics · Physics 2026-03-09 Linjie Ma , Bicong Wang , Tai Nam Yip , Yong Hou , Yuan Lin , Zhiqin Chu

Nitrogen-vacancy (NV) based quantum sensors hold great potential for real-time single-cell sensing with far-reaching applications in fundamental biology and medical diagnostics. Although highly sensitive, the mapping of quantum measurements…

Nanoindentation is vital for probing mechanical properties, yet traditional grid-based workflows are inefficient for targeting specific microstructural features. We present an automated nanoindentation framework that integrates machine…

Instrumentation and Detectors · Physics 2025-04-28 Vivek Chawla , Dayakar Penumadu , Sergei Kalinin

Nanoindentation is a powerful tool capable of providing fundamental insights of material elastic and plastic response at the nanoscale. Alloys at nanoscale are particularly interesting as the local heterogeneity and deformation mechanism…

Scattering scanning near-field optical microscopy (s-SNOM) is a powerful technique for mid-infrared spectroscopy at nanometer length scales. By investigating objects in aqueous environments through ultrathin membranes, s-SNOM has recently…

The classical problem of indentation on an elastic substrate has found new applications in the field of the Atomic Force Microscopy. However, linearly elastic indentation models are not sufficiently accurate to predict the…

Soft Condensed Matter · Physics 2022-12-14 Yangkun Du , Peter Stewart , Nicholas A Hill , Huabing Yin , Raimondo Penta , Jakub Kory , Xiaoyu Luo , Raymond Ogden

In modeling spatial processes, a second-order stationarity assumption is often made. However, for spatial data observed on a vast domain, the covariance function often varies over space, leading to a heterogeneous spatial dependence…

Methodology · Statistics 2021-02-09 Ghulam A. Qadir , Ying Sun , Sebastian Kurtek

Fluorescent nanodiamonds (FNDs) relaxometry holds promising future for advancement of high spatiotemporal resolution metabolic imaging technology. In this study, we demonstrate a simultaneous integration of spatial position tracking with…

Biological Physics · Physics 2025-12-23 Jia Su , Linyu Zeng , Pengyu Chen , Zenghao Kong , Fazhan Shi

Understanding lattice deformations is crucial in determining the properties of nanomaterials, which can become more prominent in future applications ranging from energy harvesting to electronic devices. However, it remains challenging to…

Indentation has been widely used for investigating the mechanical behavior of glasses. However, how the various microscopic properties (such as atomic structure and mechanics) of glass evolve from the immediate contact with the indenter to…

Disordered Systems and Neural Networks · Physics 2023-05-09 Linfeng Ding , Ranran Lu , Lianjun Wang , Qiuju Zheng , John C. Mauro , Zhen Zhang

Material indentation studies, in which a probe is brought into controlled physical contact with an experimental sample, have long been a primary means by which scientists characterize the mechanical properties of materials. More recently,…

Applications · Statistics 2011-10-03 Daniel Rudoy , Shelten G. Yuen , Robert D. Howe , Patrick J. Wolfe

Collocated tactile sensing is a fundamental enabling technology for dexterous manipulation. However, deformable sensors introduce complex dynamics between the robot, grasped object, and environment that must be considered for fine…

Robotics · Computer Science 2022-09-28 Miquel Oller , Mireia Planas , Dmitry Berenson , Nima Fazeli

Visual Deformation Measurement (VDM) aims to recover dense deformation fields by tracking surface motion from camera observations. Traditional image-based methods rely on minimal inter-frame motion to constrain the correspondence search…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Yuliang Wu , Wei Zhai , Yuxin Cui , Tiesong Zhao , Yang Cao , Zheng-Jun Zha
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