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Large language models (LLMs) have demonstrated remarkable capabilities in a wide range of tasks, yet their application to specialized domains remains challenging due to the need for deep expertise. Retrieval-Augmented generation (RAG) has…

Large Language Models (LLMs) have demonstrated remarkable success in various tasks such as natural language understanding, text summarization, and machine translation. However, their general-purpose nature often limits their effectiveness…

Integrating large language models (LLMs) with knowledge graphs derived from domain-specific data represents an important advancement towards more powerful and factual reasoning. As these models grow more capable, it is crucial to enable…

Recent advancements in large language models (LLMs) have achieved promising performances across various applications. Nonetheless, the ongoing challenge of integrating long-tail knowledge continues to impede the seamless adoption of LLMs in…

Knowledge graphs and large language models (LLMs) are key tools for biomedical knowledge integration and reasoning, facilitating structured organization of scientific articles and discovery of complex semantic relationships. However,…

Retrieval-Augmented Generation (RAG) has become a foundational paradigm for equipping large language models (LLMs) with external knowledge, playing a critical role in information retrieval and knowledge-intensive applications. However,…

Molecule generation and optimization is a fundamental task in chemical domain. The rapid development of intelligent tools, especially large language models (LLMs) with powerful knowledge reserves and interactive capabilities, has provided…

Large Language Models (LLMs) assist in specialized tasks but struggle to align with evolving domain knowledge without costly fine-tuning. Domain knowledge consists of: Knowledge: Immutable facts (e.g., 'A stone is solid') and generally…

Molecular property prediction is a crucial foundation for drug discovery. In recent years, pre-trained deep learning models have been widely applied to this task. Some approaches that incorporate prior biological domain knowledge into the…

Current general-purpose large language models (LLMs) commonly exhibit knowledge hallucination and insufficient domain-specific adaptability in domain-specific tasks, limiting their effectiveness in specialized question answering scenarios.…

Retrieval-augmented generation (RAG) enhances the question-answering (QA) abilities of large language models (LLMs) by integrating external knowledge. However, adapting general-purpose RAG systems to specialized fields such as science and…

Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Retrieval-Augmented Generation (RAG) has emerged as a prominent method for incorporating domain knowledge into Large Language Models (LLMs). While RAG enhances response relevance by incorporating retrieved domain knowledge in the context,…

Retrieval-augmented generation (RAG) is key to enhancing large language models (LLMs) to systematically access richer factual knowledge. Yet, using RAG brings intrinsic challenges, as LLMs must deal with potentially conflicting knowledge,…

The question-answering system for Life science research, which is characterized by the rapid pace of discovery, evolving insights, and complex interactions among knowledge entities, presents unique challenges in maintaining a comprehensive…

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Retrieval Augmented Generation (RAG) systems often struggle with domain-specific knowledge due to performance deterioration of pre-trained embeddings and prohibitive computational costs of large language model (LLM)-based retrievers. While…

Retrieval-Augmented Generation (RAG) offers a promising solution to address various limitations of Large Language Models (LLMs), such as hallucination and difficulties in keeping up with real-time updates. This approach is particularly…

Large language models (LLMs) often exhibit limited performance on domain-specific tasks due to the natural disproportionate representation of specialized information in their training data and the static nature of these datasets. Knowledge…

Large Language Models (LLMs) have shown remarkable reasoning capabilities, while their practical applications are limited by severe factual hallucinations due to limitations in the timeliness, accuracy, and comprehensiveness of their…