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In this paper we discuss design considerations and beam dynamics challenges associated with laser-driven plasma-based accelerators as applied to multi-TeV-scale linear colliders. Plasma accelerators provide ultra-high gradients and…

Accelerator Physics · Physics 2022-05-18 C. B. Schroeder , C. Benedetti , S. S. Bulanov , D. Terzani , E. Esarey , C. G. R. Geddes

The genomic evolution inherent to cancer relates directly to a renewed focus on the voluminous next generation sequencing (NGS) data, and machine learning for the inference of explanatory models of how the (epi)genomic events are…

We describe some of the challenges of particle accelerator control, highlight recent advances in neural network techniques, discuss some promising avenues for incorporating neural networks into particle accelerator control systems, and…

Accelerator Physics · Physics 2016-10-21 A. L. Edelen , S. G. Biedron , B. E. Chase , D. Edstrom , S. V. Milton , P. Stabile

In order to dissipate long-lived radioactive waste, not only high ux proton accelerator but also electron linac have been proposed. A proton accelerator directly induces nuclear fission and mutation. On the other hand, electron beam has two…

Accelerator Physics · Physics 2021-04-20 Y. Kawashima , T. Asaka , H. Ego , M. Hara

Bayesian Neural Networks (BNNs) provide superior estimates of uncertainty by generating an ensemble of predictive distributions. However, inference via ensembling is resource-intensive, requiring additional entropy sources to generate…

Emerging Technologies · Computer Science 2025-05-20 Prabodh Katti , Clement Ruah , Osvaldo Simeone , Bashir M. Al-Hashimi , Bipin Rajendran

Generative molecular design has moved from proof-of-concept to real-world applicability, as marked by the surge in very recent papers reporting experimental validation. Key challenges in explainability and sample efficiency present…

Biomolecules · Quantitative Biology 2024-03-05 Jeff Guo , Philippe Schwaller

Accelerators produce too many signals for a small operations team to monitor in real time. In addition, many of these signals are only interpretable by subject matter experts with years of experience. As a result, changes in accelerator…

Accelerator Physics · Physics 2022-12-28 Ryan Humble , Finn H. O'Shea , William Colocho , Matt Gibbs , Helen Chaffee , Eric Darve , Daniel Ratner

Large language model (LLM) inference has been a prevalent demand in daily life and industries. The large tensor sizes and computing complexities in LLMs have brought challenges to memory, computing, and databus. This paper proposes a…

Hardware Architecture · Computer Science 2025-09-19 Yimin Wang , Yue Jiet Chong , Xuanyao Fong

Generative models excel in creating realistic images, yet their dependency on extensive datasets for training presents significant challenges, especially in domains where data collection is costly or challenging. Current data-efficient…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Yuta Mimura

Cosmic-ray acceleration processes in astrophysical plasmas are often investigated with fully-kinetic or hybrid kinetic numerical simulations, which enable us to describe a detailed microphysics of particle energization mechanisms. Tracing…

High Energy Astrophysical Phenomena · Physics 2025-02-12 Gabriel Torralba Paz , Artem Bohdan , Jacek Niemiec

Injected beam energy and energy spread are critical parameters affecting the performance of our rapid cycling synchrotron (RCS). A real-time energy monitoring system is being installed to examine the H- beam out of the Intense Pulsed…

Accelerator Physics · Physics 2009-09-25 J. C. Dooling , F. R. Brumwell , M. K. Lien , G. E. McMichael

Solving linear systems of polynomial equations is a ubiquitous problem in both mathematics and physics. The standard approach, Gaussian elimination, scales cubically with system size and often constitutes a computational bottleneck. The…

Computational Physics · Physics 2026-05-26 Giuseppe De Laurentis , Jack Franklin

Traditional methods for biological shape inference, such as deep learning (DL) and active contour models, face important limitations in 3D. DL approaches require large annotated datasets, which are often impractical to obtain, while active…

Biological Physics · Physics 2025-08-04 Sacha Ichbiah , Anshuman Sinha , Fabrice Delbary , Hervé Turlier

We present the development and integration of a Machine Learning (ML)-based surrogate model, trained on Particle-In-Cell (PIC) simulations of laser-driven plasma wakefield acceleration source of electrons, into Geant4 simulation toolkit.…

Plasma Physics · Physics 2025-03-18 A. Sytov , K. Cassou , V. Kubytskyi , M. Lenivenko , A. Huber

Particle accelerators are among some of the largest science experiments in the world and can consist of thousands of components with a wide variety of input ranges. These systems can easily become unwieldy optimization problems during…

Accelerator Physics · Physics 2022-11-01 Nicole Neveu , Tyler H. Chang , Paris Franz , Stephen Hudson , Jeffrey Larson

The superconducting (SC) High Intensity and Energy (HIE) ISOLDE linac will replace most of the existing accelerating infrastructure of the Radioactive ion beam EXperiment (REX) at CERN, however, the 101.28 MHz RFQ and 5 MV IH cavity will…

Accelerator Physics · Physics 2010-10-12 M. A. Fraser , M. Pasini , R. M. Jones , D. Voulot

Biological function emerges from coupled constraints across sequence, structure, regulation, evolution, and cellular context, yet most foundation models in biology are trained within one modality or for a fixed forward task. We present…

Superconducting linacs are capable of producing intense, stable, high-quality electron beams that have found widespread applications in science and industry. The 9-cell 1.3-GHz superconducting standing-wave accelerating RF cavity originally…

Accelerator Physics · Physics 2017-04-25 A. Halavanau , N. Eddy , D. Edstrom , E. Harms , A. Lunin , P. Piot , A. Romanov , J. Ruan , N. Solyak , V. Shiltsev

Based on the particle-in-cell (PIC) plasma simulation method, the speed-limited PIC (SLPIC) method delivers faster kinetic plasma simulation in cases where the particle distributions evolve slowly compared with the maximum stable PIC…

Computational Physics · Physics 2019-01-09 Gregory R. Werner , Thomas G. Jenkins , Andrew M. Chap , John R. Cary

We present a topology for linear accelerators (linacs) that permits larger degrees of freedom for the optimization of individual cavity shapes. The power is distributed to the cavities through a waveguide with periodic apertures that…

Accelerator Physics · Physics 2020-09-16 Sami Tantawi , Mamdouh Nasr , Zenghai Li , Cecile Limborg , Philipp Borchard
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