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During the past few years, mediation analysis has gained increasing popularity across various research fields. The primary objective of mediation analysis is to examine the direct impact of exposure on outcome, as well as the indirect…

Computation · Statistics 2023-05-18 Haixiang Zhang , Xin Li

Coordinated online behavior, which spans from beneficial collective actions to harmful manipulation such as disinformation campaigns, has become a key focus in digital ecosystem analysis. Traditional methods often rely on monomodal…

Social and Information Networks · Computer Science 2026-02-16 Lorenzo Mannocci , Stefano Cresci , Matteo Magnani , Anna Monreale , Maurizio Tesconi

We propose a novel approach for causal mediation analysis based on changes-in-changes assumptions restricting unobserved heterogeneity over time. This allows disentangling the causal effect of a binary treatment on a continuous outcome into…

Econometrics · Economics 2020-10-13 Martin Huber , Mark Schelker , Anthony Strittmatter

Mediation analysis seeks to understand the mechanism by which a treatment affects an outcome. Count or zero-inflated count outcome are common in many studies in which mediation analysis is of interest. For example, in dental studies,…

Methodology · Statistics 2016-07-12 Zijian Guo , Dylan S. Small , Stuart A. Gansky , Jing Cheng

Physical activity has long been shown to be associated with biological and physiological performance and risk of diseases. It is of great interest to assess whether the effect of an exposure or intervention on an outcome is mediated through…

Subgroup-specific meta-analysis synthesizes treatment effects for patient subgroups across randomized trials. Methods include joint or separate modeling of subgroup effects and treatment-by-subgroup interactions, but inconsistencies arise…

Methodology · Statistics 2025-08-22 Renato Panaro , Christian Röver , Tim Friede

In the field of disparities research, there has been growing interest in developing a counterfactual-based decomposition analysis to identify underlying mediating mechanisms that help reduce disparities in populations. Despite rapid…

Methodology · Statistics 2022-05-27 Soojin Park , Chioun Lee , Xu Qin

In randomized trials, once the total effect of the intervention has been estimated, it is often of interest to explore mechanistic effects through mediators along the causal pathway between the randomized treatment and the outcome. In the…

Methodology · Statistics 2021-12-28 Erin E Gabriel , Michael C Sachs , Arvid Sjölander

The presence of intermediate confounders, also called recanting witnesses, is a fundamental challenge to the investigation of causal mechanisms in mediation analysis, preventing the identification of natural path-specific effects. Proposed…

Methodology · Statistics 2024-01-10 Tat-Thang Vo , Nicholas Williams , Richard Liu , Kara E. Rudolph , Ivan Dıaz

A key objective of decomposition analysis is to identify a factor (the 'mediator') contributing to disparities in an outcome between social groups. In decomposition analysis, a scholarly interest often centers on estimating how much the…

Methodology · Statistics 2022-05-27 Soojin Park , Suyeon Kang , Chioun Lee , Shujie Ma

The paper presents an investigation of estimating treatment effect using different matching methods. The study proposed a new method which is computationally efficient and convenient in implication-'largest caliper matching' and compared…

Applications · Statistics 2018-06-07 Sharif Mahmood

In randomized trials, researchers are often interested in mediation analysis to understand how a treatment works, in particular how much of a treatment's effect is mediated by an intermediated variable and how much the treatment directly…

Methodology · Statistics 2013-01-01 Dylan S. Small

Mediation analyses allow researchers to quantify the effect of an exposure variable on an outcome variable through a mediator variable. If a binary mediator variable is misclassified, the resulting analysis can be severely biased.…

Methodology · Statistics 2024-07-19 Kimberly A. Hochstedler Webb , Martin T. Wells

Individual participant data (IPD) meta-analyses of randomised trials are considered a reliable way to assess participant-level treatment effect modifiers but may not make the best use of the available data. Traditionally, effect modifiers…

Causal mediation analysis of observational data is an important tool for investigating the potential causal effects of medications on disease-related risk factors, and on time-to-death (or disease progression) through these risk factors.…

Causal mediation analysis decomposes the total treatment effect into a portion operating through a hypothesized mediator and a residual direct portion. Identification of natural direct and indirect effects typically rests on the mediator…

Methodology · Statistics 2026-05-19 Yuki Ohnishi , Fan Li

We study a multiagent learning problem where agents can either learn via repeated interactions, or can follow the advice of a mediator who suggests possible actions to take. We present an algorithmthat each agent can use so that, with high…

Computer Science and Game Theory · Computer Science 2012-06-18 Greg Hines , Kate Larson

Common methods for interpreting neural models in natural language processing typically examine either their structure or their behavior, but not both. We propose a methodology grounded in the theory of causal mediation analysis for…

Computation and Language · Computer Science 2020-11-24 Jesse Vig , Sebastian Gehrmann , Yonatan Belinkov , Sharon Qian , Daniel Nevo , Simas Sakenis , Jason Huang , Yaron Singer , Stuart Shieber

Matching estimators for average treatment effects are widely used in the binary treatment setting, in which missing potential outcomes are imputed as the average of observed outcomes of all matches for each unit. With more than two…

Methodology · Statistics 2019-04-29 Anthony D. Scotina , Francesca L. Beaudoin , Roee Gutman

Estimating treatment effects conditional on observed covariates can improve the ability to tailor treatments to particular individuals. Doing so effectively requires dealing with potential confounding, and also enough data to adequately…

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