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This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Large language models (LLMs) have shown remarkable achievements in natural language processing tasks, producing high-quality outputs. However, LLMs still exhibit limitations, including the generation of factually incorrect information. In…

Computation and Language · Computer Science 2023-11-17 Sridevi Wagle , Sai Munikoti , Anurag Acharya , Sara Smith , Sameera Horawalavithana

Treating uncertainties in models is essential in many fields of science and engineering. Uncertainty quantification (UQ) on complex and computationally costly numerical models necessitates a combination of efficient model solvers, advanced…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-04-28 Linus Seelinger , Anne Reinarz , Jean Benezech , Mikkel Bue Lykkegaard , Lorenzo Tamellini , Robert Scheichl

Recent advancements in large language models (LLMs) are propelling us toward artificial general intelligence with their remarkable emergent abilities and reasoning capabilities. However, the substantial computational and memory requirements…

Machine Learning · Computer Science 2024-10-10 Ruihao Gong , Yang Yong , Shiqiao Gu , Yushi Huang , Chengtao Lv , Yunchen Zhang , Xianglong Liu , Dacheng Tao

Hallucinations pose a significant challenge to the reliability and alignment of Large Language Models (LLMs), limiting their widespread acceptance beyond chatbot applications. Despite ongoing efforts, hallucinations remain a prevalent…

Computation and Language · Computer Science 2024-02-27 Cem Uluoglakci , Tugba Taskaya Temizel

Uncertainty quantification (UQ) in machine learning is currently drawing increasing research interest, driven by the rapid deployment of deep neural networks across different fields, such as computer vision, natural language processing, and…

Machine Learning · Computer Science 2022-08-26 Zongren Zou , Xuhui Meng , Apostolos F Psaros , George Em Karniadakis

LLM-as-a-Judge is a widely used method for evaluating the performance of Large Language Models (LLMs) across various tasks. We address the challenge of quantifying the uncertainty of LLM-as-a-Judge evaluations. While uncertainty…

Uncertainty Quantification (UQ) is essential in probabilistic machine learning models, particularly for assessing the reliability of predictions. In this paper, we present a systematic framework for estimating both epistemic and aleatoric…

Machine Learning · Statistics 2025-09-11 Marzieh Ajirak , Anand Ravishankar , Petar M. Djuric

Uncertainty quantification (UQ) methods for large language models are predominantly designed by hand based on domain knowledge and heuristics, limiting their scalability and generality. We apply LLM-powered evolutionary search to…

Computation and Language · Computer Science 2026-04-07 Mikhail Seleznyov , Daniil Korbut , Viktor Moskvoretskii , Oleg Somov , Alexander Panchenko , Elena Tutubalina

Large Language Models (LLMs) display formidable capabilities in generative tasks but also pose potential risks due to their tendency to generate hallucinatory responses. Uncertainty Quantification (UQ), the evaluation of model output…

Computation and Language · Computer Science 2024-12-11 Qinhong Lin , Linna Zhou , Zhongliang Yang , Yuang Cai

Large language models (LLMs) often generate fluent but factually incorrect outputs, known as hallucinations, which undermine their reliability in real-world applications. While uncertainty estimation has emerged as a promising strategy for…

Machine Learning · Computer Science 2025-05-13 Pei-Fu Guo , Yun-Da Tsai , Shou-De Lin

Uncertainty quantification enables users to assess the reliability of responses generated by large language models (LLMs). We present a novel Question Rephrasing technique to evaluate the input uncertainty of LLMs, which refers to the…

Computation and Language · Computer Science 2024-08-08 Zizhang Chen , Pengyu Hong , Sandeep Madireddy

Accurate uncertainty quantification in large language models (LLMs) is essential for reliable confidence estimation, yet fine-tuned LLMs often become overconfident under limited adaptation data. Existing uncertainty methods for PEFT-based…

Machine Learning · Computer Science 2026-05-15 Ruijia Niu , Dongxia Wu , Rose Yu , Yi-An Ma

Uncertainty Quantification (UQ) for Natural Language Generation (NLG) is crucial for assessing the performance of Large Language Models (LLMs), as it reveals confidence in predictions, identifies failure modes, and gauges output…

Computation and Language · Computer Science 2025-04-09 Sean Wang , Yicheng Jiang , Yuxin Tang , Lu Cheng , Hanjie Chen

Modern Large Language Models (LLMs) often require external tools, such as machine learning classifiers or knowledge retrieval systems, to provide accurate answers in domains where their pre-trained knowledge is insufficient. This…

Machine Learning · Computer Science 2025-05-23 Panagiotis Lymperopoulos , Vasanth Sarathy

Large language models have shown impressive capabilities in code generation, yet they often produce functionally incorrect code. Uncertainty quantification (UQ) methods have emerged as a promising approach for detecting hallucinations in…

Computation and Language · Computer Science 2026-05-28 Dylan Bouchard , Mohit Singh Chauhan , Zeya Ahmad , Ho-Kyeong Ra

Uncertainty quantification (UQ) is an essential tool for applying deep neural networks (DNNs) to real world tasks, as it attaches a degree of confidence to DNN outputs. However, despite its benefits, UQ is often left out of the standard DNN…

Computer Vision and Pattern Recognition · Computer Science 2024-10-07 Nils Lehmann , Jakob Gawlikowski , Adam J. Stewart , Vytautas Jancauskas , Stefan Depeweg , Eric Nalisnick , Nina Maria Gottschling

Large language models (LLMs) have revolutionized the field of natural language processing with their impressive reasoning and question-answering capabilities. However, these models are sometimes prone to generating credible-sounding but…

Computation and Language · Computer Science 2026-04-21 Ranganath Krishnan , Piyush Khanna , Omesh Tickoo

With the widespread application of Large Language Models (LLMs) to various domains, concerns regarding the trustworthiness of LLMs in safety-critical scenarios have been raised, due to their unpredictable tendency to hallucinate and…

Computation and Language · Computer Science 2024-11-04 Xin Qiu , Risto Miikkulainen

We explore uncertainty quantification in large language models (LLMs), with the goal to identify when uncertainty in responses given a query is large. We simultaneously consider both epistemic and aleatoric uncertainties, where the former…

Machine Learning · Computer Science 2024-07-18 Yasin Abbasi Yadkori , Ilja Kuzborskij , András György , Csaba Szepesvári
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