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This paper introduces MAD-MIL, a Multi-head Attention-based Deep Multiple Instance Learning model, designed for weakly supervised Whole Slide Images (WSIs) classification in digital pathology. Inspired by the multi-head attention mechanism…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Hassan Keshvarikhojasteh , Josien Pluim , Mitko Veta

Whole slide image (WSI) classification requires repetitive zoom-in and out for pathologists, as only small portions of the slide may be relevant to detecting cancer. Due to the lack of patch-level labels, multiple instance learning (MIL) is…

Computer Vision and Pattern Recognition · Computer Science 2023-11-30 Seongho Keum , Sanghyun Kim , Soojeong Lee , Juho Lee

Self-attention mechanism has been widely used for various tasks. It is designed to compute the representation of each position by a weighted sum of the features at all positions. Thus, it can capture long-range relations for computer vision…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Xia Li , Zhisheng Zhong , Jianlong Wu , Yibo Yang , Zhouchen Lin , Hong Liu

The latent representation in learned image compression encompasses channel-wise, local spatial, and global spatial correlations, which are essential for the entropy model to capture for conditional entropy minimization. Efficiently…

Image and Video Processing · Electrical Eng. & Systems 2025-10-29 Wei Jiang , Jiayu Yang , Yongqi Zhai , Feng Gao , Ronggang Wang

Transformer models rely on Multi-Head Self-Attention (MHSA) mechanisms, where each attention head contributes to the final representation. However, their computational complexity and high memory demands due to MHSA hinders their deployment…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Lucas Maisonnave , Karim Haroun , Tom Pegeot

Multi-instance data, in which each object (bag) contains a collection of instances, are widespread in machine learning, computer vision, bioinformatics, signal processing, and social sciences. We present a maximum entropy (ME) framework for…

Machine Learning · Computer Science 2016-03-15 Behrouz Behmardi , Forrest Briggs , Xiaoli Z. Fern , Raviv Raich

Multiple instance learning (MIL) is the standard approach for whole-slide image (WSI) classification and survival prediction, where attention-based models ag gregate patch features into slide-level predictions. These models treat attention…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Xiangyu Li , Ran Su

Whole body magnetic resonance imaging (WB-MRI) is the recommended modality for diagnosis of multiple myeloma (MM). WB-MRI is used to detect sites of disease across the entire skeletal system, but it requires significant expertise and is…

We introduce the attention-indexed model (AIM), a theoretical framework for analyzing learning in deep attention layers. Inspired by multi-index models, AIM captures how token-level outputs emerge from layered bilinear interactions over…

Machine Learning · Computer Science 2026-02-03 Fabrizio Boncoraglio , Emanuele Troiani , Vittorio Erba , Lenka Zdeborová

Many leading self-supervised methods for unsupervised representation learning, in particular those for embedding image features, are built on variants of the instance discrimination task, whose optimization is known to be prone to…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Daniel Shalam , Simon Korman

In computational pathology, whole-slide image (WSI) classification presents a formidable challenge due to its gigapixel resolution and limited fine-grained annotations. Multiple-instance learning (MIL) offers a weakly supervised solution,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Renao Yan , Qiehe Sun , Cheng Jin , Yiqing Liu , Yonghong He , Tian Guan , Hao Chen

In whole slide images (WSIs) analysis, attention-based multi-instance learning (MIL) models are susceptible to spurious correlations and degrade under domain shift. These methods may assign high attention weights to non-tumor regions, such…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Xin Liu , Weijia Zhang , Wei Tang , Thuc Duy Le , Jiuyong Li , Lin Liu , Min-Ling Zhang

In the realm of digital pathology, multi-magnification Multiple Instance Learning (multi-mag MIL) has proven effective in leveraging the hierarchical structure of Whole Slide Images (WSIs) to reduce information loss and redundant data.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Yujian Liu , Ruoxuan Wu , Xinjie Shen , Zihuang Lu , Lingyu Liang , Haiyu Zhou , Shipu Xu , Shaoai Cai , Shidang Xu

Multiple Instance Learning (MIL) models have proven effective for cancer prognosis from Whole Slide Images. However, the original MIL formulation incorrectly assumes the patches of the same image to be independent, leading to a loss of…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Thiziri Nait Saada , Valentina Di Proietto , Benoit Schmauch , Katharina Von Loga , Lucas Fidon

Multiple Instance Learning (MIL) represents the predominant framework in Whole Slide Image (WSI) classification, covering aspects such as sub-typing, diagnosis, and beyond. Current MIL models predominantly rely on instance-level features…

Computer Vision and Pattern Recognition · Computer Science 2024-07-26 Heng Fang , Sheng Huang , Wenhao Tang , Luwen Huangfu , Bo Liu

Active learning is a promising alternative to alleviate the issue of high annotation cost in the computer vision tasks by consciously selecting more informative samples to label. Active learning for object detection is more challenging and…

Computer Vision and Pattern Recognition · Computer Science 2022-04-19 Jiaxi Wu , Jiaxin Chen , Di Huang

Representation learning is currently a very hot topic in modern machine learning, mostly due to the great success of the deep learning methods. In particular low-dimensional representation which discriminates classes can not only enhance…

Machine Learning · Computer Science 2015-04-13 Wojciech Marian Czarnecki , Rafał Józefowicz , Jacek Tabor

A new multi-attention based method for solving the MIL problem (MAMIL), which takes into account the neighboring patches or instances of each analyzed patch in a bag, is proposed. In the method, one of the attention modules takes into…

Machine Learning · Computer Science 2021-12-14 Andrei V. Konstantinov , Lev V. Utkin

Multi-instance learning (MIL) is a form of weakly supervised learning where a single class label is assigned to a bag of instances while the instance-level labels are not available. Training classifiers to accurately determine the bag label…

Computer Vision and Pattern Recognition · Computer Science 2020-06-11 Bin Li , Kevin W. Eliceiri

Large Language Models (LLMs) encounter significant performance bottlenecks in long-sequence tasks due to the computational complexity and memory overhead inherent in the self-attention mechanism. To address these challenges, we introduce…

Artificial Intelligence · Computer Science 2026-02-17 Ziming Wang , Xiang Wang , Kailong Peng , Lang Qin , Juan Gabriel Kostelec , Christos Sourmpis , Axel Laborieux , Qinghai Guo