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The clinical adoption of artificial intelligence (AI) in medical diagnostics is critically hampered by its black-box nature, which prevents clinicians from verifying the rationale behind automated decisions. To overcome this fundamental…

Deep learning has shown remarkable results for image analysis and is expected to aid individual treatment decisions in health care. To achieve this, deep learning methods need to be promoted from the level of mere associations to being able…

Machine Learning · Computer Science 2022-05-02 Wouter A. C. van Amsterdam , Marinus J. C. Eijkemans

As black-box AI-driven decision-making systems become increasingly widespread in modern document processing workflows, improving their transparency and reliability has become critical, especially in high-stakes applications where biases or…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Saifullah Saifullah , Stefan Agne , Andreas Dengel , Sheraz Ahmed

This paper addresses the challenge of generating Counterfactual Explanations (CEs), involving the identification and modification of the fewest necessary features to alter a classifier's prediction for a given image. Our proposed method,…

Computer Vision and Pattern Recognition · Computer Science 2023-11-16 Guillaume Jeanneret , Loïc Simon , Frédéric Jurie

Explainable AI (XAI) is a research area whose objective is to increase trustworthiness and to enlighten the hidden mechanism of opaque machine learning techniques. This becomes increasingly important in case such models are applied to the…

Machine Learning · Computer Science 2021-04-19 Danilo Numeroso , Davide Bacciu

The application of deep learning in medical imaging has significantly advanced diagnostic capabilities, enhancing both accuracy and efficiency. Despite these benefits, the lack of transparency in these AI models, often termed "black boxes,"…

Computer Vision and Pattern Recognition · Computer Science 2024-09-23 Eleonora Beatrice Rossi , Eleonora Lopez , Danilo Comminiello

Artificial Intelligence has emerged as a useful aid in numerous clinical applications for diagnosis and treatment decisions. Deep neural networks have shown same or better performance than clinicians in many tasks owing to the rapid…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Zohaib Salahuddin , Henry C Woodruff , Avishek Chatterjee , Philippe Lambin

Reliable and interpretable decision-making is essential in medical imaging, where diagnostic outcomes directly influence patient care. Despite advances in deep learning, most medical AI systems operate as opaque black boxes, providing…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Pirzada Suhail , Aditya Anand , Amit Sethi

Interpretable machine learning seeks to understand the reasoning process of complex black-box systems that are long notorious for lack of explainability. One flourishing approach is through counterfactual explanations, which provide…

Artificial Intelligence · Computer Science 2023-06-02 Vy Vo , Trung Le , Van Nguyen , He Zhao , Edwin Bonilla , Gholamreza Haffari , Dinh Phung

The image-based diagnosis is now a vital aspect of modern automation assisted diagnosis. To enable models to produce pixel-level diagnosis, pixel-level ground-truth labels are essentially required. However, since it is often not straight…

Computer Vision and Pattern Recognition · Computer Science 2023-01-24 Tehseen Zia , Zeeshan Nisar , Shakeeb Murtaza

The last decade has witnessed the proliferation of Deep Learning models in many applications, achieving unrivaled levels of predictive performance. Unfortunately, the black-box nature of Deep Learning models has posed unanswered questions…

Machine Learning · Computer Science 2020-03-26 Alejandro Barredo-Arrieta , Javier Del Ser

Black box systems for automated decision making, often based on machine learning over (big) data, map a user's features into a class or a score without exposing the reasons why. This is problematic not only for lack of transparency, but…

Artificial Intelligence · Computer Science 2018-06-27 Dino Pedreschi , Fosca Giannotti , Riccardo Guidotti , Anna Monreale , Luca Pappalardo , Salvatore Ruggieri , Franco Turini

With the availability of large databases and recent improvements in deep learning methodology, the performance of AI systems is reaching or even exceeding the human level on an increasing number of complex tasks. Impressive examples of this…

Artificial Intelligence · Computer Science 2017-08-29 Wojciech Samek , Thomas Wiegand , Klaus-Robert Müller

Scientific expertise often requires recognizing subtle visual differences that remain challenging to articulate even for domain experts. We present a system that leverages generative models to automatically discover and visualize minimal…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Mia Chiquier , Orr Avrech , Yossi Gandelsman , Berthy Feng , Katherine Bouman , Carl Vondrick

Machine learning (ML) applications have automated numerous real-life tasks, improving both private and public life. However, the black-box nature of many state-of-the-art models poses the challenge of model verification; how can one be sure…

Machine Learning · Computer Science 2022-01-19 Ioannis Papantonis , Vaishak Belle

Generative AI has redefined artificial intelligence, enabling the creation of innovative content and customized solutions that drive business practices into a new era of efficiency and creativity. In this paper, we focus on diffusion…

Machine Learning · Computer Science 2024-03-21 Zihao Li , Hui Yuan , Kaixuan Huang , Chengzhuo Ni , Yinyu Ye , Minshuo Chen , Mengdi Wang

While deep learning models have demonstrated remarkable success in numerous domains, their black-box nature remains a significant limitation, especially in critical fields such as medical image analysis and inference. Existing…

Machine Learning · Computer Science 2025-05-13 David Zucker

Explanation techniques that synthesize small, interpretable changes to a given image while producing desired changes in the model prediction have become popular for introspecting black-box models. Commonly referred to as counterfactuals,…

Machine Learning · Computer Science 2021-10-06 Jayaraman J. Thiagarajan , Vivek Narayanaswamy , Deepta Rajan , Jason Liang , Akshay Chaudhari , Andreas Spanias

Causal inference and the estimation of causal effects plays a central role in decision-making across many areas, including healthcare and economics. Estimating causal effects typically requires an estimator that is tailored to each problem…

This research presents an innovative approach to cancer diagnosis and prediction using explainable Artificial Intelligence (XAI) and deep learning techniques. With cancer causing nearly 10 million deaths globally in 2020, early and accurate…

Artificial Intelligence · Computer Science 2024-12-24 Badaru I. Olumuyiwa , The Anh Han , Zia U. Shamszaman