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Related papers: Transferable Boltzmann Generators

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Diffusion models have recently driven significant breakthroughs in generative modeling. While state-of-the-art models produce high-quality samples on average, individual samples can still be low quality. Detecting such samples without human…

Machine Learning · Computer Science 2025-06-13 Metod Jazbec , Eliot Wong-Toi , Guoxuan Xia , Dan Zhang , Eric Nalisnick , Stephan Mandt

A widely used electrostatics model in the biomolecular modeling community, the nonlinear Poisson-Boltzmann equation, along with its finite element approximation, are analyzed in this paper. A regularized Poisson-Boltzmann equation is…

Numerical Analysis · Mathematics 2010-01-12 Long Chen , Michael Holst , Jinchao Xu

In this study, we address the challenge of using energy-based models to produce high-quality, label-specific data in complex structured datasets, such as population genetics, RNA or protein sequences data. Traditional training methods…

Machine Learning · Computer Science 2025-02-07 Alessandra Carbone , Aurélien Decelle , Lorenzo Rosset , Beatriz Seoane

Elucidating reaction mechanisms hinges on efficiently generating transition states (TSs), products, and complete reaction networks. Recent generative models, such as diffusion models for TS sampling and sequence-based architectures for…

Chemical Physics · Physics 2025-11-06 Ping Tuo , Jiale Chen , Ju Li

Estimating three-dimensional conformations of a molecular graph allows insight into the molecule's biological and chemical functions. Fast generation of valid conformations is thus central to molecular modeling. Recent advances in…

Machine Learning · Computer Science 2025-02-18 Sohil Atul Shah , Vladlen Koltun

It has been proven that Boson sampling is a much promising model of optical quantum computation, which has been applied to designing quantum computer successfully, such as "Jiuzhang". However, the meaningful randomness of Boson sampling…

Quantum Physics · Physics 2022-06-07 Jinjing Shi , Tongge Zhao , Yizhi Wang , Chunlin Yu , Yuhu Lu , Ronghua Shi , Shichao Zhang , Junjie Wu

In this paper we propose a novel approach to construct macroscopic balance equations and constitutive equations describing various irreversible phenomena. It is based on the general principles of non-equilibrium thermodynamics and consists…

Statistical Mechanics · Physics 2014-11-27 Liu Hong , Zaibao Yang , Yi Zhu , Wen-An Yong

The Lattice Boltzmann method (LBM) is a well-established mesoscopic approach for simulating fluid dynamics by evolving particle distribution functions on discrete lattices. While the LBM is highly parallelizable on classical hardware, its…

Quantum Physics · Physics 2026-04-14 Trong Duong , Matthias Möller , Norbert Hosters

The individual optimization of quantum circuit parameters is currently one of the main practical bottlenecks in variational quantum eigensolvers for electronic systems. To this end, several machine learning approaches have been proposed to…

Quantum Physics · Physics 2025-11-06 Davide Bincoletto , Korbinian Stein , Jonas Motyl , Jakob S. Kottmann

Recent advances in generative modeling, namely Diffusion models, have revolutionized generative modeling, enabling high-quality image generation tailored to user needs. This paper proposes a framework for the generative design of structural…

Deep Generative Models (DGMs), including Energy-Based Models (EBMs) and Score-based Generative Models (SGMs), have advanced high-fidelity data generation and complex continuous distribution approximation. However, their application in…

Machine Learning · Computer Science 2024-10-03 Yangming Li , Chieh-Hsin Lai , Carola-Bibiane Schönlieb , Yuki Mitsufuji , Stefano Ermon

We introduce a novel training principle for probabilistic models that is an alternative to maximum likelihood. The proposed Generative Stochastic Networks (GSN) framework is based on learning the transition operator of a Markov chain whose…

Machine Learning · Computer Science 2015-03-29 Guillaume Alain , Yoshua Bengio , Li Yao , Jason Yosinski , Eric Thibodeau-Laufer , Saizheng Zhang , Pascal Vincent

Boltzmann solvers are an important tool for the computation of cosmological observables in the linear regime. In the presence of massive neutrinos, they involve solving the Boltzmann equation followed by an integration in momentum space to…

Cosmology and Nongalactic Astrophysics · Physics 2021-11-22 Caio Bastos de Senna Nascimento

Deep generative models provide a systematic way to learn nonlinear data distributions, through a set of latent variables and a nonlinear "generator" function that maps latent points into the input space. The nonlinearity of the generator…

Machine Learning · Statistics 2021-12-14 Georgios Arvanitidis , Lars Kai Hansen , Søren Hauberg

We present a simple generative framework for learning to predict previously unseen classes, based on estimating class-attribute-gated class-conditional distributions. We model each class-conditional distribution as an exponential family…

Machine Learning · Computer Science 2018-01-26 Vinay Kumar Verma , Piyush Rai

Generating a Boltzmann distribution in high dimension has recently been achieved with Normalizing Flows, which enable fast and exact computation of the generated density, and thus unbiased estimation of expectations. However, current…

Machine Learning · Computer Science 2023-01-16 Loris Felardos , Jérôme Hénin , Guillaume Charpiat

With the recent advances in machine learning for quantum chemistry, it is now possible to predict the chemical properties of compounds and to generate novel molecules. Existing generative models mostly use a string- or graph-based…

Biomolecules · Quantitative Biology 2020-10-14 Vitali Nesterov , Mario Wieser , Volker Roth

Energy-Based Models (EBMs) provide a flexible framework for generative modeling, but their training remains theoretically challenging due to the need to approximate normalization constants and efficiently sample from complex, multi-modal…

Machine Learning · Computer Science 2025-06-10 Davide Carbone

Many recent flow-matching and diffusion-style generative models rely on auxiliary stochastic dynamics during training: a richer process is simulated to define conditional targets, but the auxiliary state is either intractable to sample at…

Machine Learning · Computer Science 2026-05-21 Lukas Billera , Hedwig Nora Nordlinder , Ben Murrell

Deep learning methods relying on multi-layered networks have been actively studied in a wide range of fields in recent years, and deep Boltzmann machines(DBMs) is one of them. In this study, a model of DBMs with some properites of weight…

Disordered Systems and Neural Networks · Physics 2022-10-06 Yuma Ichikawa , Koji Hukushima