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Large language models (LLMs) with billions of parameters and pretrained on massive amounts of data are now capable of near or better than state-of-the-art performance in a variety of downstream natural language processing tasks. Neural…

Computation and Language · Computer Science 2024-07-08 Victor Agostinelli , Max Wild , Matthew Raffel , Kazi Ahmed Asif Fuad , Lizhong Chen

Emerging topics in biomedical research are continuously expanding, providing a wealth of information about genes and their function. This rapid proliferation of knowledge presents unprecedented opportunities for scientific discovery and…

Genomics · Quantitative Biology 2024-12-25 Zhijian Chen , Chuan Hu , Min Wu , Qingqing Long , Xuezhi Wang , Yuanchun Zhou , Meng Xiao

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Artificial Intelligence · Computer Science 2025-04-21 Yijia Xiao , Edward Sun , Yiqiao Jin , Qifan Wang , Wei Wang

Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose…

Computation and Language · Computer Science 2025-11-25 Yanjun Lyu , Zihao Wu , Lu Zhang , Jing Zhang , Yiwei Li , Wei Ruan , Zhengliang Liu , Zeyu Zhang , Xiang Li , Rongjie Liu , Chao Huang , Wentao Li , Tianming Liu , Dajiang Zhu

As foundational tools in natural language processing, Large Language Models (LLMs) have immense parameter scales, which makes deployment and inference increasingly prohibitive, especially in resource-constrained devices. Therefore,…

Quantum Physics · Physics 2025-08-04 Lingxiao Li , Yihao Wang , Jiacheng Fan , Jing Li , Sujuan Qin , Qiaoyan Wen , Fei Gao

Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current analysis methods often struggle with…

The complexity and heterogeneity of data in many real-world applications pose significant challenges for traditional machine learning and signal processing techniques. For instance, in medicine, effective analysis of diverse physiological…

Machine Learning · Computer Science 2024-08-16 Nimeesha Chan , Felix Parker , William Bennett , Tianyi Wu , Mung Yao Jia , James Fackler , Kimia Ghobadi

We propose DISC-MedLLM, a comprehensive solution that leverages Large Language Models (LLMs) to provide accurate and truthful medical response in end-to-end conversational healthcare services. To construct high-quality Supervised…

Computation and Language · Computer Science 2023-08-29 Zhijie Bao , Wei Chen , Shengze Xiao , Kuang Ren , Jiaao Wu , Cheng Zhong , Jiajie Peng , Xuanjing Huang , Zhongyu Wei

Spatial transcriptomics (ST) technologies have revolutionized the study of gene expression patterns in tissues by providing multimodality data in transcriptomic, spatial, and morphological, offering opportunities for understanding tissue…

Computational Engineering, Finance, and Science · Computer Science 2024-01-17 Zelin Zang , Liangyu Li , Yongjie Xu , Chenrui Duan , Kai Wang , Yang You , Yi Sun , Stan Z. Li

Large language models (LLMs) show promise for improving the efficiency of qualitative analysis in large, multi-site health-services research. Yet methodological guidance for LLM integration into qualitative analysis and evidence of their…

Computation and Language · Computer Science 2026-01-22 Sasha Ronaghi , Emma-Louise Aveling , Maria Levis , Rachel Lauren Ross , Emily Alsentzer , Sara Singer

Quantum State Tomography (QST) is a fundamental technique in Quantum Information Processing (QIP) for reconstructing unknown quantum states. However, the conventional QST methods are limited by the number of measurements required, which…

Traffic prediction, an essential component for intelligent transportation systems, endeavours to use historical data to foresee future traffic features at specific locations. Although existing traffic prediction models often emphasize…

Machine Learning · Computer Science 2024-07-09 Chenxi Liu , Sun Yang , Qianxiong Xu , Zhishuai Li , Cheng Long , Ziyue Li , Rui Zhao

Large language models (LLMs) are typically deployed with fixed parameters, and their performance is often improved by allocating more computation at inference time. While such test-time scaling can be effective, it cannot correct model…

Computation and Language · Computer Science 2026-05-15 Chaehee Song , Minseok Seo , Yeeun Seong , Doyi Kim , Changick Kim

Large language models (LLMs) have immense potential to make information more accessible, particularly in medicine, where complex medical jargon can hinder patient comprehension of clinical notes. We developed a patient-facing tool using…

Large Language Models (LLMs) contribute significantly to the development of conversational AI and has great potentials to assist the scientific research in various areas. This paper attempts to address the following questions: What…

Quantum Physics · Physics 2023-07-18 Zhiding Liang , Jinglei Cheng , Rui Yang , Hang Ren , Zhixin Song , Di Wu , Xuehai Qian , Tongyang Li , Yiyu Shi

Simultaneous speech translation (SST) outputs translations in parallel with streaming speech input, balancing translation quality and latency. While large language models (LLMs) have been extended to handle the speech modality, streaming…

Computation and Language · Computer Science 2025-04-23 Keqi Deng , Wenxi Chen , Xie Chen , Philip C. Woodland

Large language models (LLMs) are a class of artificial intelligence models based on deep learning, which have great performance in various tasks, especially in natural language processing (NLP). Large language models typically consist of…

Quantitative Methods · Quantitative Biology 2025-02-04 Jiajia Liu , Mengyuan Yang , Yankai Yu , Haixia Xu , Tiangang Wang , Kang Li , Xiaobo Zhou

Since the release of ChatGPT and GPT-4, large language models (LLMs) and multimodal large language models (MLLMs) have attracted widespread attention for their exceptional capabilities in understanding, reasoning, and generation,…

Computation and Language · Computer Science 2024-12-31 Hanguang Xiao , Feizhong Zhou , Xingyue Liu , Tianqi Liu , Zhipeng Li , Xin Liu , Xiaoxuan Huang

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

There exist various Software Development Kits (SDKs) tailored to different quantum computing platforms. These are known as Quantum SDKs (QSDKs). Examples include but are not limited to Qiskit, Cirq, and PennyLane. However, this diversity…

Software Engineering · Computer Science 2025-12-09 Nazanin Siavash , Armin Moin