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Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to…

Image and Video Processing · Electrical Eng. & Systems 2022-09-15 Xuanyu Tian , Qing Wu , Hongjiang Wei , Yuyao Zhang

The inability to acquire clean high-resolution (HR) electron microscopy (EM) images over a large brain tissue volume hampers many neuroscience studies. To address this challenge, we propose a deep-learning-based image super-resolution (SR)…

Computer Vision and Pattern Recognition · Computer Science 2024-01-29 Mohammad Khateri , Morteza Ghahremani , Alejandra Sierra , Jussi Tohka

In fluorescence microscopy live-cell imaging, there is a critical trade-off between the signal-to-noise ratio and spatial resolution on one side, and the integrity of the biological sample on the other side. To obtain clean high-resolution…

Image and Video Processing · Electrical Eng. & Systems 2020-08-25 Ruofan Zhou , Majed El Helou , Daniel Sage , Thierry Laroche , Arne Seitz , Sabine Süsstrunk

Recently, self-supervised neural networks have shown excellent image denoising performance. However, current dataset free methods are either computationally expensive, require a noise model, or have inadequate image quality. In this work we…

Computer Vision and Pattern Recognition · Computer Science 2023-05-11 Youssef Mansour , Reinhard Heckel

Hyperspectral stimulated Raman scattering (SRS) microscopy is a label-free technique for biomedical and mineralogical imaging which can suffer from low signal to noise ratios. Here we demonstrate the use of an unsupervised deep learning…

Deep learning (DL) has shown promise for faster, high quality accelerated MRI reconstruction. However, supervised DL methods depend on extensive amounts of fully-sampled (labeled) data and are sensitive to out-of-distribution (OOD) shifts,…

Super-resolution (SR) methods have seen significant advances thanks to the development of convolutional neural networks (CNNs). CNNs have been successfully employed to improve the quality of endomicroscopy imaging. Yet, the inherent…

Image and Video Processing · Electrical Eng. & Systems 2021-03-26 Agnieszka Barbara Szczotka , Dzhoshkun Ismail Shakir , Matthew J. Clarkson , Stephen P. Pereira , Tom Vercauteren

Magnetic resonance imaging (MRI) is a powerful noninvasive diagnostic imaging tool that provides unparalleled soft tissue contrast and anatomical detail. Noise contamination, especially in accelerated and/or low-field acquisitions, can…

Image and Video Processing · Electrical Eng. & Systems 2025-05-12 Jiachen Tu , Yaokun Shi , Fan Lam

Noise is an important issue for radiographic and tomographic imaging techniques. It becomes particularly critical in applications where additional constraints force a strong reduction of the Signal-to-Noise Ratio (SNR) per image. These…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Yaroslav Zharov , Evelina Ametova , Rebecca Spiecker , Tilo Baumbach , Genoveva Burca , Vincent Heuveline

Image denoising is a prerequisite for downstream tasks in many fields. Low-dose and photon-counting computed tomography (CT) denoising can optimize diagnostic performance at minimized radiation dose. Supervised deep denoising methods are…

Machine Learning · Computer Science 2022-01-06 Chuang Niu , Mengzhou Li , Fenglei Fan , Weiwen Wu , Xiaodong Guo , Qing Lyu , Ge Wang

Recently introduced zero-shot self-supervised learning (ZS-SSL) has shown potential in accelerated MRI in a scan-specific scenario, which enabled high-quality reconstructions without access to a large training dataset. ZS-SSL has been…

Image and Video Processing · Electrical Eng. & Systems 2023-11-30 Heng Yu , Yamin Arefeen , Berkin Bilgic

Recent methods for single image super-resolution (SISR) have demonstrated outstanding performance in generating high-resolution (HR) images from low-resolution (LR) images. However, most of these methods show their superiority using…

Computer Vision and Pattern Recognition · Computer Science 2022-08-25 Jun-Sang Yoo , Dong-Wook Kim , Yucheng Lu , Seung-Won Jung

Neural network (NN) based approaches for super-resolution MRI typically require high-SNR high-resolution reference data acquired in many subjects, which is time consuming and a barrier to feasible and accessible implementation. We propose…

Image and Video Processing · Electrical Eng. & Systems 2022-11-11 Jiaxin Xiao , Zihan Li , Berkin Bilgic , Jonathan R. Polimeni , Susie Huang , Qiyuan Tian

In the last few years, image denoising has benefited a lot from the fast development of neural networks. However, the requirement of large amounts of noisy-clean image pairs for supervision limits the wide use of these models. Although…

Image and Video Processing · Electrical Eng. & Systems 2021-04-01 Tao Huang , Songjiang Li , Xu Jia , Huchuan Lu , Jianzhuang Liu

Image denoising is a fundamental problem in computer vision and medical imaging. However, real-world images are often degraded by structured noise with strong anisotropic correlations that existing methods struggle to remove. Most…

Image and Video Processing · Electrical Eng. & Systems 2025-10-03 Jianxu Wang , Ge Wang

In the last few years, with the rapid development of deep learning technologies, supervised methods based on convolutional neural networks have greatly enhanced the performance of medical image denoising. However, these methods require…

Image and Video Processing · Electrical Eng. & Systems 2025-03-10 Langrui Zhou , Ziteng Zhou , Xinyu Huang , Huiru Wang , Xiangyu Zhang , Guang Li

Purpose: This work proposes a novel self-supervised noise-adaptive image denoising framework, called Repetition to Repetition (Rep2Rep) learning, for low-field (<1T) MRI applications. Methods: Rep2Rep learning extends the Noise2Noise…

Image and Video Processing · Electrical Eng. & Systems 2025-12-03 Nikola Janjušević , Jingjia Chen , Luke Ginocchio , Mary Bruno , Yuhui Huang , Yao Wang , Hersh Chandarana , Li Feng

Deep Learning has led to a dramatic leap in Super-Resolution (SR) performance in the past few years. However, being supervised, these SR methods are restricted to specific training data, where the acquisition of the low-resolution (LR)…

Computer Vision and Pattern Recognition · Computer Science 2017-12-19 Assaf Shocher , Nadav Cohen , Michal Irani

Microscopy image analysis often requires the segmentation of objects, but training data for this task is typically scarce and hard to obtain. Here we propose DenoiSeg, a new method that can be trained end-to-end on only a few annotated…

Computer Vision and Pattern Recognition · Computer Science 2020-06-12 Tim-Oliver Buchholz , Mangal Prakash , Alexander Krull , Florian Jug

Self-supervised image denoising techniques emerged as convenient methods that allow training denoising models without requiring ground-truth noise-free data. Existing methods usually optimize loss metrics that are calculated from multiple…

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